Home Other Building Blocks 699-83-2
699-83-2,MFCD00002270
Catalog No.:AA0032YY

699-83-2 | 2',6'-Dihydroxyacetophenone

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Purity
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Price(USD)
Quantity
  
1g
98%
in stock  
$2.00   $1.00
- +
5g
98%
in stock  
$7.00   $5.00
- +
10g
98%
in stock  
$10.00   $7.00
- +
25g
98%
in stock  
$22.00   $15.00
- +
100g
98%
in stock  
$67.00   $47.00
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500g
98%
in stock  
$229.00   $160.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0032YY
Chemical Name:
2',6'-Dihydroxyacetophenone
CAS Number:
699-83-2
Molecular Formula:
C8H8O3
Molecular Weight:
152.1473
MDL Number:
MFCD00002270
SMILES:
CC(=O)c1c(O)cccc1O
NSC Number:
615
Properties
Properties
 
BP:
234.6°C (rough estimate)  
Form:
Solid  
MP:
156-158 °C(lit.)  
Refractive Index:
1.4447 (estimate)  
Solubility:
dioxane: 50 mg/mL, clear  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
145  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
1.4  

Upstream Synthesis Route

[1]Patent:EP331422,1991,A3,

[1]Patent:US4996296,1991,A,

[2]Patent:EP331422,1991,A3,

[1]JournalofFluorineChemistry,2014,vol.160,p.77-81

[1]SyntheticCommunications,2009,vol.39,#11,p.1949-1956

[1]Rasayanam,1936,vol.1,p.64,66

[2]JournaloftheChemicalSociety,1934,p.1953

[3]JournaloftheAmericanChemicalSociety,1940,vol.62,p.1441,1443

[4]Org.Synth.Coll.Vol.III<1955>281,284,

[5]JournaloftheChemicalSociety,1934,p.1483

[6]YakugakuZasshi,1935,vol.55,p.176,179

[7]ChemischeBerichte,1942,vol.75,p.785,792

Downstream Synthesis Route

[1]JournalofOrganicChemistry,2008,vol.73,p.8901-8920

[2]ChemicalCommunications,2019,vol.55,p.9837-9840

[3]Patent:WO2014/149793,2014,A1.Locationinpatent:Page/Pagecolumn42-43

[4]Patent:WO2015/13318,2015,A1.Locationinpatent:Paragraph0173-0174

[5]JournaloftheAmericanChemicalSociety,1991,vol.113,p.5707-5714

[6]JournaloftheAmericanChemicalSociety,1940,vol.62,p.1441,1443

[7]ChemicalandPharmaceuticalBulletin,1979,vol.27,p.1490-1494

[8]SyntheticCommunications,1985,vol.15,p.1315-1324

[9]Patent:WO2015/79251,2015,A1.Locationinpatent:Paragraph00243;00244

[1]Baker;Brown;Scott[JournaloftheChemicalSociety,1939,p.1922,1926]

[1]Patent:WO2013/83991,2013,A1.Locationinpatent:Page/Pagecolumn65-66

[2]EuropeanJournalofMedicinalChemistry,1987,vol.22,p.153-156

[3]MedicinalChemistryResearch,2013,vol.22,p.5472-5480

[4]JournaloftheChemicalSociety,1951,p.3235,3238

[5]BioorganicandMedicinalChemistryLetters,2001,vol.11,p.1833-1837

[1]Patent:CN103570661,2016,B.Locationinpatent:Paragraph0017-0018

[2]EuropeanJournalofMedicinalChemistry,2016,vol.115,p.381-392

[3]Patent:CN105175374,2017,B.Locationinpatent:Paragraph0039-0041;0060;0080;0100

[4]Patent:CN105153089,2018,B.Locationinpatent:Paragraph0040;0056;0068;0071-0073

[5]LiebigsAnnalenderChemie,1990,p.795-805

[6]JournaloftheChemicalSociety,1939,p.956,959

[7]BioorganicandMedicinalChemistryLetters,2004,vol.14,p.1165-1167

[8]EuropeanJournalofMedicinalChemistry,2009,vol.44,p.2552-2562

[9]EuropeanJournalofMedicinalChemistry,2016,vol.109,p.124-133

[1]JournalofMedicinalChemistry,2003,vol.46,p.2125-2131

[2]Chemistry-AEuropeanJournal,2011,vol.17,p.5130-5137

[3]Patent:WO2005/33101,2005,A1.Locationinpatent:Page/Pagecolumn16

[4]JournalofOrganicChemistry,1987,vol.52,p.1670-1673

[5]Heterocycles,1986,vol.24,p.1099-1107

[6]EuropeanJournalofOrganicChemistry,2012,p.1768-1773

[7]JournalofMedicinalChemistry,2013,vol.56,p.5019-5032

[8]BioorganicandMedicinalChemistry,2016,vol.24,p.2768-2776

[9]YakugakuZasshi/JournalofthePharmaceuticalSocietyofJapan,1939,vol.59,p.495,499;dtsch.Ref.S.194    Chem.Abstr.,1940,p.106

[10]Phytochemistry,1982,vol.21,p.517-524

[11]JournalofOrganicChemistry,1993,vol.58,p.7903-7905

[12]Patent:US4092416,1978,A

[13]BioorganicandMedicinalChemistryLetters,2016,vol.26,p.3098-3102

Literature

Title: Evaluation of 2,6-dihydroxyacetophenone as matrix-assisted laser desorption/ionization matrix for analysis of hydrophobic proteins and peptides.

Journal: Analytical biochemistry 20120601

Title: An efficient and selective way to new highly functionalized coronands or spiro derivatives using ultrasonic irradiation.

Journal: Ultrasonics sonochemistry 20120501

Title: A new Schiff base compound N,N'-(2,2-dimetylpropane)-bis(dihydroxylacetophenone): synthesis, experimental and theoretical studies on its crystal structure, FTIR, UV-visible, 1H NMR and 13C NMR spectra.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111015

Title: Murine tyrosinase inhibitors from Cynanchum bungei and evaluation of in vitro and in vivo depigmenting activity.

Journal: Experimental dermatology 20110901

Title: Deciphering the complexity of sainfoin (Onobrychis viciifolia) proanthocyanidins by MALDI-TOF mass spectrometry with a judicious choice of isotope patterns and matrixes.

Journal: Analytical chemistry 20110601

Title: Laserspray ionization, a new method for protein analysis directly from tissue at atmospheric pressure with ultrahigh mass resolution and electron transfer dissociation.

Journal: Molecular & cellular proteomics : MCP 20110201

Title: Enhanced MALDI-TOF MS analysis of phosphopeptides using an optimized DHAP/DAHC matrix.

Journal: Journal of biomedicine & biotechnology 20100101

Title: 355 nm multiphoton dissociation and ionization of 2, 5-dihydroxyacetophenone.

Journal: The journal of physical chemistry. A 20091231

Title: Diazinium salts with dihydroxyacetophenone skeleton: Syntheses and antimicrobial activity.

Journal: European journal of medicinal chemistry 20090501

Title: Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20090201

Title: Molecular modeling and inhibition of phospholipase A2 by polyhydroxy phenolic compounds.

Journal: European journal of medicinal chemistry 20090101

Title: [Determination of four acetophenones in Radix Cynanchi bungei by high performance liquid chromatography-photodiode array detection].

Journal: Se pu = Chinese journal of chromatography 20090101

Title: Parameters contributing to efficient ion generation in aerosol MALDI mass spectrometry.

Journal: Journal of the American Society for Mass Spectrometry 20080301

Title: Selective enrichment and fractionation of phosphopeptides from peptide mixtures by isoelectric focusing after methyl esterification.

Journal: Analytical chemistry 20070301

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: Inhibitory effects of choleretic hydroxyacetophenones on ileal bile acid transport in rats.

Journal: Life sciences 20060227

Title: 2,5-Dihydroxyacetophenone: a matrix for highly sensitive matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of proteins using manual and automated preparation techniques.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: A one-step synthesis of 2-Alkyl-5-hydroxychromones and 3-Alkoyl-2-alkyl-5-hydroxychromones.

Journal: Chemical & pharmaceutical bulletin 20051101

Title: MALDI mass spectrometry in the solution of some forensic problems.

Journal: Forensic science international 20041202

Title: Novel squalene-hopene cyclase inhibitors derived from hydroxycoumarins and hydroxyacetophenones.

Journal: Chemical & pharmaceutical bulletin 20041001

Title: The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids.

Journal: Biochemical and biophysical research communications 20020705

Title: Steroid hormone activity of flavonoids and related compounds.

Journal: Breast cancer research and treatment 20000701

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