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[1]ChemicalandPharmaceuticalBulletin,1987,vol.35,p.2373-2381
[1]Patent:CN106220699,2016,A.Locationinpatent:Paragraph0010;0042
[2]Heterocycles,1990,vol.31,p.569-574
[1]Chemicalandpharmaceuticalbulletin,1987,vol.35,p.2090-2094
[1]Chemicalandpharmaceuticalbulletin,1987,vol.35,p.2090-2094
Title: A phase 1 study of the pharmacokinetics of nucleoside analog trifluridine and thymidine phosphorylase inhibitor tipiracil (components of TAS-102) vs trifluridine alone.
Journal: Investigational new drugs 20170101
Title: Effect of food on the pharmacokinetics of TAS-102 and its efficacy and safety in patients with advanced solid tumors.
Journal: Cancer science 20160501
Title: Human mass balance study of TAS-102 using (14)C analyzed by accelerator mass spectrometry.
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Title: TAS-102, a novel antitumor agent: a review of the mechanism of action.
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Title: Screening of a chemical library reveals novel PXR-activating pharmacologic compounds.
Journal: Toxicology letters 20150105
Title: Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models.
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Title: TAS-102: more than an antimetabolite.
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Title: Pediatric herpes simplex of the anterior segment: characteristics, treatment, and outcomes.
Journal: Ophthalmology 20121001
Title: TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial.
Journal: The Lancet. Oncology 20121001
Title: Phase I study of TAS-102 treatment in Japanese patients with advanced solid tumours.
Journal: British journal of cancer 20120724
Title: Ganciclovir ophthalmic gel 0.15%: safety and efficacy of a new treatment for herpes simplex keratitis.
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Title: Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluorothymidine, a novel antitumor nucleoside, in rats.
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Title: Viral infection in renal transplant recipients.
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Title: Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism.
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Title: A systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological data.
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Title: Enhancing effect of Labrasol on the intestinal absorption of ganciclovir in rats.
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Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
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Title: Highly regioselective synthesis of 3'-O-acyl-trifluridines catalyzed by Pseudomonas cepacia lipase.
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Title: Unilateral keratitis following death of a twin as the presenting sign of herpetic infection in a neonate.
Journal: Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 20111001
Title: Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes.
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Title: Ocular vaccinia: a consequence of unrecognized contact transmission.
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Title: Herpes keratitis in a patient undergoing treatment with topical mitomycin C.
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Title: Evaluation of therapeutic interventions for vaccinia virus keratitis.
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Title: Treatment of viral conjunctivitis with antiviral drugs.
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Title: In vitro synergism of trifluorothymidine and ganciclovir against HSV-1.
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Title: Photographic monitoring of herpes simplex virus keratitis during anti-inflammatory treatment.
Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20110201
Title: Inhibition of viral replication in vitro by antiviral-treated amniotic membrane. Possible use of amniotic membrane as drug-delivering tool.
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Title: Inflammatory glaucoma.
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Title: Experimental bariatric surgery in rats generates a cytotoxic chemical environment in the gut contents.
Journal: Frontiers in microbiology 20110101
Title: Combination therapies in ophthalmology: implications for intravitreal delivery.
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Title: Antiviral activity of 2,3'-anhydro and related pyrimidine nucleosides against hepatitis B virus.
Journal: Bioorganic & medicinal chemistry letters 20101115
Title: Antiviral activity of various 1-(2'-deoxy-β-D-lyxofuranosyl), 1-(2'-fluoro-β-D-xylofuranosyl), 1-(3'-fluoro-β-D-arabinofuranosyl), and 2'-fluoro-2',3'-didehydro-2',3'-dideoxyribose pyrimidine nucleoside analogues against duck hepatitis B virus (DHBV) and human hepatitis B virus (HBV) replication.
Journal: Journal of medicinal chemistry 20101014
Title: Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs.
Journal: Aging 20101001
Title: Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines.
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Title: Historical perspectives in the development of antiviral agents against poxviruses.
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Title: Prodrug activation by Cryptosporidium thymidine kinase.
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Title: Differential activation of cell death and autophagy results in an increased cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells.
Journal: International journal of cancer 20100515
Title: Immunohistochemical characterization of pyrimidine synthetic enzymes, thymidine kinase-1 and thymidylate synthase, in various types of cancer.
Journal: Oncology reports 20100501
Title: Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2.
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Title: Quantitative organ time activity curve extraction from rodent PET images without anatomical prior.
Journal: Medical physics 20100401
Title: Molecular mechanism underlying the synergistic interaction between trifluorothymidine and the epidermal growth factor receptor inhibitor erlotinib in human colorectal cancer cell lines.
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Title: Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3.
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Title: Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells.
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Title: Structure activity relationship of dendrimer microbicides with dual action antiviral activity.
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Title: Topical ganciclovir in the treatment of acute herpetic keratitis.
Journal: Clinical ophthalmology (Auckland, N.Z.) 20100101
Title: Simple and rapid enzymatic method for the synthesis of single-strand oligonucleotides containing trifluorothymidine.
Journal: Nucleosides, nucleotides & nucleic acids 20100101
Title: Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.
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Title: Slitlamp biomicroscopy and photographic image analysis of herpes simplex virus stromal keratitis.
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Title: A human apolipoprotein E mimetic peptide effectively inhibits HSV-1 TK-positive and TK-negative acute epithelial keratitis in rabbits.
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Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Journal: Journal of medicinal chemistry 20081113
Title: Synergistic interaction between trifluorothymidine and docetaxel is sequence dependent.
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Title: Synthesis of nucleoside-based antiviral drugs in ionic liquids.
Journal: Bioorganic & medicinal chemistry letters 20081015
Title: Effective treatment of ocular HSK with a human apolipoprotein E mimetic peptide in a mouse eye model.
Journal: Investigative ophthalmology & visual science 20081001
Title: Phase 1 study of TAS-102 administered once daily on a 5-day-per-week schedule in patients with solid tumors.
Journal: Investigational new drugs 20081001
Title: Phase I clinical study of three times a day oral administration of TAS-102 in patients with solid tumors.
Journal: Cancer investigation 20081001
Title: [18F]FDG and [18F]FLT uptake in human breast cancer cells in relation to the effects of chemotherapy: an in vitro study.
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Title: Ocular pharmacokinetics of acyclovir amino acid ester prodrugs in the anterior chamber: evaluation of their utility in treating ocular HSV infections.
Journal: International journal of pharmaceutics 20080709
Title: Trifluorothymidine induces cell death independently of p53.
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Title: Efficacy of a helicase-primase inhibitor in animal models of ocular herpes simplex virus type 1 infection.
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Title: Therapeutic interventions for herpes simplex virus epithelial keratitis.
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Title: Novel cell death mechanisms of trifluorothymidine.
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Title: Progressive hypertrophic genital herpes in an HIV-infected woman despite immune recovery on antiretroviral therapy.
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Title: Collision induced dissociation studies of alkali metal adducts of tetracyclines and antiviral agents by electrospray ionization, hydrogen/deuterium exchange and multiple stage mass spectrometry.
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Title: Ganciclovir ophthalmic gel, 0.15%: a valuable tool for treating ocular herpes.
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Title: Collisionally-induced dissociation of substituted pyrimidine antiviral agents: mechanisms of ion formation using gas phase hydrogen/deuterium exchange and electrospray ionization tandem mass spectrometry.
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Title: Evidence-based treatment of herpes simplex virus keratitis: a systematic review.
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Title: Therapeutic potential of the dual-targeted TAS-102 formulation in the treatment of gastrointestinal malignancies.
Journal: Cancer science 20070601
Title: Mechanism of trifluorothymidine potentiation of oxaliplatin-induced cytotoxicity to colorectal cancer cells.
Journal: British journal of cancer 20070129
Title: Therapeutic interventions for herpes simplex virus epithelial keratitis.
Journal: The Cochrane database of systematic reviews 20070124
Title: The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells.
Journal: British journal of cancer 20070115
Title: A method to distinguish between the de novo induction of thymidine kinase mutants and the selection of pre-existing thymidine kinase mutants in the mouse lymphoma assay.
Journal: Mutation research 20070110
Title: Irinotecan-induced cytotoxicity to colon cancer cells in vitro is stimulated by pre-incubation with trifluorothymidine.
Journal: European journal of cancer (Oxford, England : 1990) 20070101
Title: Dendritic keratitis caused by an acyclovir-resistant herpes simplex virus with frameshift mutation.
Journal: Cornea 20070101
Title: High level glucose increases mutagenesis in human lymphoblastoid cells.
Journal: International journal of biological sciences 20070101
Title: Phase I study to determine the safety and pharmacokinetics of oral administration of TAS-102 in patients with solid tumors.
Journal: Cancer 20060915
Title: American Society of Clinical Oncology--42nd annual meeting. Poster presentations on leukemia and cytotoxic chemotherapy. 2-6 June 2006, Atlanta, GA, USA.
Journal: IDrugs : the investigational drugs journal 20060801
Title: Corneal ulceration associated with naturally occurring canine herpesvirus-1 infection in two adult dogs.
Journal: Journal of the American Veterinary Medical Association 20060801
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: 3D-QSAR studies on antitubercular thymidine monophosphate kinase inhibitors based on different alignment methods.
Journal: Bioorganic & medicinal chemistry letters 20060215
Title: Imiquimod 5% cream for the treatment of recurrent, acyclovir-resistant genital herpes.
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060215
Title: Low folate conditions may enhance the interaction of trifluorothymidine with antifolates in colon cancer cells.
Journal: Cancer chemotherapy and pharmacology 20060101
Title: Viral infections affecting the skin in organ transplant recipients: epidemiology and current management strategies.
Journal: American journal of clinical dermatology 20060101
Title: Ocular vaccinia infection in laboratory worker, Philadelphia, 2004.
Journal: Emerging infectious diseases 20060101
Title: In vitro comparison of antiviral drugs against feline herpesvirus 1.
Journal: BMC veterinary research 20060101
Title: Microarray analysis distinguishes differential gene expression patterns from large and small colony Thymidine kinase mutants of L5178Y mouse lymphoma cells.
Journal: BMC bioinformatics 20060101
Title: Dipeptide monoester ganciclovir prodrugs for treating HSV-1-induced corneal epithelial and stromal keratitis: in vitro and in vivo evaluations.
Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20051201
Title: Herpes simplex keratitis misdiagnosed as rheumatoid arthritis-related peripheral ulcerative keratitis.
Journal: Cornea 20051101
Title: Efficacy of topical aciclovir for the treatment of feline herpetic keratitis: results of a prospective clinical trial and data from in vitro investigations.
Journal: The Veterinary record 20050827
Title: Potentiation of the antitumor activity of alpha, alpha, alpha-trifluorothymidine by the co-administration of an inhibitor of thymidine phosphorylase at a suitable molar ratio in vivo.
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Title: Determinants of trifluorothymidine sensitivity and metabolism in colon and lung cancer cells.
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Title: Multinodular goiter management in Western Saudi Arabia.
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Title: Intracellular immunity to HIV-1: newly defined retroviral battles inside infected cells.
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Title: Ocular complications in the Department of Defense Smallpox Vaccination Program.
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Title: Association between ocular herpes simplex virus and topical ocular hypotensive therapy.
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Title: Role of platelet derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity and potential role of deoxyribose-1-phosphate.
Journal: Nucleosides, nucleotides & nucleic acids 20041001
Title: Intracellular thymidylate synthase inhibition by trifluorothymidine in FM3A cells.
Journal: Nucleosides, nucleotides & nucleic acids 20041001
Title: A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA.
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Title: Herpes simplex virus keratitis in children.
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Title: Antiviral drugs in current clinical use.
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Title: Pharmacokinetic modeling of species-dependent enhanced bioavailability of trifluorothymidine by thymidine phosphorylase inhibitor.
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Title: The effect of fluoropyrimidines with or without thymidine phosphorylase inhibitor on the expression of thymidine phosphorylase.
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Title: A novel antimetabolite, TAS-102 retains its effect on FU-related resistant cancer cells.
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Title: Arthrographis keratitis mimicking acanthamoeba keratitis.
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Title: Ocular vaccinia following exposure to a smallpox vaccinee.
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Title: Thymidine kinase and thymidine phosphorylase level as the main predictive parameter for sensitivity to TAS-102 in a mouse model.
Journal: Oncology reports 20040201
Title: An optimal dosing schedule for a novel combination antimetabolite, TAS-102, based on its intracellular metabolism and its incorporation into DNA.
Journal: International journal of molecular medicine 20040201
Title: Management of ophthalmic zoster mucous plaque keratopathy: report of three cases.
Journal: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20040201
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