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70563-58-5,MFCD00151702
Catalog No.:AA00F9TE

70563-58-5 | HERBIMYCIN A

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2.5mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00F9TE
Chemical Name:
HERBIMYCIN A
CAS Number:
70563-58-5
Molecular Formula:
C30H42N2O9
Molecular Weight:
574.6625
MDL Number:
MFCD00151702
SMILES:
COC1C(C)C=C(C)C(OC(=O)N)C(OC)C=CC=C(C(=O)NC2=CC(=O)C=C(C(C(CC1OC)C)OC)C2=O)C
Properties
Computed Properties
 
Complexity:
1150  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Defined Bond Stereocenter Count:
3  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
1.8  

Literature

Title: Herbimycins D-F, ansamycin analogues from Streptomyces sp. RM-7-15.

Journal: Journal of natural products 20130927

Title: Narrow-band UVB irradiation stimulates the migration and functional development of vitiligo-IgG antibodies-treated pigment cells.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20120401

Title: Inhibitors of tyrosine kinases and phosphatases as a tool for the investigation of microtubule role in plant cold response.

Journal: TSitologiia i genetika 20120101

Title: Characterization of the Src/Abl hybrid kinase SmTK6 of Schistosoma mansoni.

Journal: The Journal of biological chemistry 20111209

Title: Molecular mechanisms of cold-induced CYP1A activation in rat liver microsomes.

Journal: Journal of physiology and biochemistry 20111201

Title: Correlation of seven biological factors (Hsp90a, p53, MDM2, Bcl-2, Bax, Cytochrome C, and Cleaved caspase3) with clinical outcomes of ALK+ anaplastic large-cell lymphoma.

Journal: Biomedical and environmental sciences : BES 20111201

Title: Integrin-associated tyrosine kinase FAK affects Cbfa1 expression.

Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20110901

Title: [Regulation of invasion behavior of ERK-mediated trophoblast by focal adhesion kinase].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20110601

Title: Effect of pertussis toxin and herbimycin A on proteinase-activated receptor 2-mediated cyclooxygenase 2 expression in Helicobacter pylori-infected gastric epithelial AGS cells.

Journal: Yonsei medical journal 20110501

Title: c-Src is required for complex formation between the hepatitis C virus-encoded proteins NS5A and NS5B: a prerequisite for replication.

Journal: Hepatology (Baltimore, Md.) 20110401

Title: The inhibitory mechanisms of the tyrosine kinase inhibitors herbimycin a, genistein, and tyrphostin B48 with regard to the function of the aryl hydrocarbon receptor in Caco-2 cells.

Journal: Bioscience, biotechnology, and biochemistry 20100101

Title: Pressure activates Src-dependent FAK-Akt and ERK1/2 signaling pathways in rat hepatic stellate cells.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

Title: Src supports UDP-glucuronosyltransferase-2B7 detoxification of catechol estrogens associated with breast cancer.

Journal: Biochemical and biophysical research communications 20090515

Title: Participation of the human sperm proteasome in the capacitation process and its regulation by protein kinase A and tyrosine kinase.

Journal: Biology of reproduction 20090501

Title: HPV16 E6 oncoprotein increases cell adhesion in human keratinocytes.

Journal: Archives of virology 20090101

Title: Therapeutic surfactants modulate the viability of eosinophils and induce inflammatory mediator release.

Journal: International archives of allergy and immunology 20090101

Title: Mitogen-activated protein kinases and NFkappaB are involved in SP-A-enhanced responses of macrophages to mycobacteria.

Journal: Respiratory research 20090101

Title: Comparison of the effect of heat shock factor inhibitor, KNK437, on heat shock- and chemical stress-induced hsp30 gene expression in Xenopus laevis A6 cells.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20081001

Title: PP2 regulates human trophoblast cells differentiation by activating p38 and ERK1/2 and inhibiting FAK activation.

Journal: Placenta 20081001

Title: Regulation of cytosolic phospholipase A2alpha by hsp90 and a p54 kinase in okadaic acid-stimulated macrophages.

Journal: Journal of leukocyte biology 20080901

Title: Fibronectin promotes cell proliferation of human pre-B cell line via its interactions with VLA-4 and VLA-5.

Journal: Hematology (Amsterdam, Netherlands) 20080801

Title: Effects of tyrosine kinase and phosphatase inhibitors on microtubules in Arabidopsis root cells.

Journal: Cell biology international 20080601

Title: Endogenous Gas6 and Ca2+ -channel activation modulate phagocytosis by retinal pigment epithelium.

Journal: Cellular signalling 20080601

Title: Protein tyrosine kinase inhibitors modify kainic acid-induced epileptiform activity and mossy fiber sprouting but do not protect against limbic cell death.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20080501

Title: Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels.

Journal: The Journal of biological chemistry 20080321

Title: Flow-dependent regulation of angiopoietin-2.

Journal: Journal of cellular physiology 20080201

Title: Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis.

Journal: Chemico-biological interactions 20080110

Title: IL-1beta stimulates urokinase-type plasminogen activator expression and secretion in human dental pulp cells.

Journal: Biomedical research (Tokyo, Japan) 20071201

Title: RhoA required for acid-induced stress fiber formation and trafficking and activation of NHE3.

Journal: American journal of physiology. Renal physiology 20071001

Title: Effects of genistein and herbimycin, tyrosine kinase inhibitors, on catecholamine release in bovine adrenal chromaffin cells.

Journal: Autonomic & autacoid pharmacology 20071001

Title: Development of a conditional bioluminescent transplant model for TPM3-ALK-induced tumorigenesis as a tool to validate ALK-dependent cancer targeted therapy.

Journal: Cancer biology & therapy 20070801

Title: Inhibition of NF-KB does not induce c-Jun N-terminal kinase-mediated apoptosis in reperfusion injury.

Journal: Journal of the American College of Surgeons 20070501

Title: Antioxidant properties of dihydroherbimycin A from a newly isolated Streptomyces sp.

Journal: Biotechnology letters 20070401

Title: Hsp90 inhibitors suppress HCV replication in replicon cells and humanized liver mice.

Journal: Biochemical and biophysical research communications 20070223

Title: Generation of reactive oxygen species is an early event in dolichyl phosphate-induced apoptosis.

Journal: Journal of cellular biochemistry 20070201

Title: Total synthesis of herbimycin A.

Journal: Organic letters 20070104

Title: Monocyte macrophage differentiation in vitro: Fibronectin-dependent upregulation of certain macrophage-specific activities.

Journal: Glycoconjugate journal 20070101

Title: Hypokalemia potentiates ouabain's effect on calcium cycling and cardiac growth.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20061230

Title: [Influence of signal transduction modulators on the secretory function of T lymphocytes in severely scalded mice and its mechanism].

Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20061201

Title: Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal growth factor receptor in human gallbladder adenocarcinoma cells.

Journal: Cancer chemotherapy and pharmacology 20061101

Title: Herbimycin A suppresses mitotic activity and egg production of female Schistosoma mansoni.

Journal: International journal for parasitology 20061001

Title: Low-energy helium-neon laser induces locomotion of the immature melanoblasts and promotes melanogenesis of the more differentiated melanoblasts: recapitulation of vitiligo repigmentation in vitro.

Journal: The Journal of investigative dermatology 20060901

Title: Insulin-like growth factor-I increases bone sialoprotein (BSP) expression through fibroblast growth factor-2 response element and homeodomain protein-binding site in the proximal promoter of the BSP gene.

Journal: Journal of cellular physiology 20060801

Title: Cell-adhesion inhibitors produced by a sea hare-derived Periconia sp. II. Absolute stereostructures of peribysins H and I.

Journal: The Journal of antibiotics 20060601

Title: Studies on the syntheses of benzoquinone ansamycin antibiotics. Syntheses of the C5-C15 subunits of macbecin I, geldanamycin, and herbimycin A.

Journal: Organic letters 20060525

Title: Actinobacillus actinomycetemcomitans lipopolysaccharide stimulates the phosphorylation of p44 and p42 MAP kinases through CD14 and TLR-4 receptor activation in human gingival fibroblasts.

Journal: Life sciences 20060425

Title: Effects of herbimycin A in the pilocarpine model of temporal lobe epilepsy.

Journal: Brain research 20060407

Title: Src family kinases play multiple roles in differentiation of trophoblasts from human term placenta.

Journal: The Journal of physiology 20060315

Title: Transactivation of fetal liver kinase-1/kinase-insert domain-containing receptor by lysophosphatidylcholine induces vascular endothelial cell proliferation.

Journal: Endocrinology 20060301

Title: Cholecystokinin stimulates the recruitment of the Src-RhoA-phosphoinositide 3-kinase pathway by Vav-2 downstream of G(alpha13) in pancreatic acini.

Journal: Biochemical and biophysical research communications 20060106

Title: Are tyrosine kinases involved in mediating contraction-stimulated muscle glucose transport?

Journal: American journal of physiology. Endocrinology and metabolism 20060101

Title: Regulation of CD93 cell surface expression by protein kinase C isoenzymes.

Journal: Microbiology and immunology 20060101

Title: Basic fibroblast growth factor promotes melanocyte migration via increased expression of p125(FAK) on melanocytes.

Journal: Acta dermato-venereologica 20060101

Title: Participation of tyrosine kinase and phospholipase Cgamma in isradipine-induced proliferation of cultured human gingival fibroblasts.

Journal: European journal of medical research 20051207

Title: Inhibition of Hsp90 function delays and impairs recovery from heat shock.

Journal: The FEBS journal 20051001

Title: Induction of p53 by urokinase in lung epithelial cells.

Journal: The Journal of biological chemistry 20050729

Title: Loss of mitochondrial membrane potential and caspase activation enhance apoptosis in irradiated K562 cells treated with herbimycin A.

Journal: International journal of radiation biology 20050701

Title: Insulin stimulates Ca2+ uptake via PKC, cAMP, and p38 MAPK in mouse embryonic stem cells.

Journal: Life sciences 20050506

Title: Heat-stable enterotoxin of Escherichia coli stimulates a non-CFTR-mediated duodenal bicarbonate secretory pathway.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20050401

Title: Platelet-activating factor increases VE-cadherin tyrosine phosphorylation in mouse endothelial cells and its association with the PtdIns3'-kinase.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050401

Title: Involvement of c-Src and protein kinase C delta in the inhibition of Cl(-)/OH- exchange activity in Caco-2 cells by serotonin.

Journal: The Journal of biological chemistry 20050325

Title: Transient activation of Ras-dependent signalling at the early stages of Herbimycin A induced erythroid differentiation of human K562 cells.

Journal: Experimental oncology 20050301

Title: [Possibility of targeting FLT3 kinase for the treatment of leukemia].

Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology 20050301

Title: Protective effects of insulin during ischemia-reperfusion injury in hamster cheek pouch microcirculation.

Journal: Journal of vascular research 20050101

Title: Effects of unoprostone and endothelin 1 on L-type channel currents in human trabecular meshwork cells.

Journal: Ophthalmic research 20050101

Title: Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity.

Journal: The Journal of biological chemistry 20041210

Title: SHP2 binds catalase and acquires a hydrogen peroxide-resistant phosphatase activity via integrin-signaling.

Journal: FEBS letters 20041119

Title: Effects of TGF-beta, TNF-alpha, IL-beta and IL-6 alone or in combination, and tyrosine kinase inhibitor on cyclooxygenase expression, prostaglandin E2 production and bone resorption in mouse calvarial bone cells.

Journal: The international journal of biochemistry & cell biology 20041101

Title: Src tyrosine kinase regulates CYP17 expression and androstenedione secretion in theca-enriched mouse ovarian cells.

Journal: Endocrine 20041101

Title: The sphingomyelin/ceramide pathway is involved in ERK1/2 phosphorylation, cell proliferation, and uPAR overexpression induced by tissue-type plasminogen activator.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040901

Title: Different effects of calcium channel blockers on matrix metalloproteinase-2 expression in cultured rat cardiac fibroblasts.

Journal: Journal of cardiovascular pharmacology 20040801

Title: Effects of magnesium on matrix metalloproteinase-2 production in cultured rat cardiac fibroblasts.

Journal: Basic research in cardiology 20040701

Title: Involvement of thromboxane A2 and tyrosine kinase in the synergistic interaction of platelet activating factor and calcium ionophore A23187 in human platelet aggregation.

Journal: Experimental & molecular medicine 20040630

Title: Biotinylated geldanamycin.

Journal: The Journal of organic chemistry 20040625

Title: Catalase binds Grb2 in tumor cells when stimulated with serum or ligands for integrin receptors.

Journal: Free radical biology & medicine 20040615

Title: Ectopic cyclin D1 expression blocks STI571-induced erythroid differentiation of K562 cells.

Journal: Leukemia research 20040601

Title: Herbimycin A abrogates nuclear factor-kappaB activation by interacting preferentially with the IkappaB kinase beta subunit.

Journal: Molecular pharmacology 20040601

Title: Platelet-derived growth factor-induced arachidonic acid release for enhancement of prostaglandin E(2) synthesis in human gingival fibroblasts pretreated with interleukin-1beta.

Journal: Journal of cellular biochemistry 20040601

Title: Evidence that hsp90 is involved in the altered interactions of Acanthamoeba castellanii variants with bacteria.

Journal: Eukaryotic cell 20040601

Title: Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity.

Journal: Experimental eye research 20040501

Title: [The role of tyrosine phosphorylation proteins in procollagen gene expression of fibroblasts in wound healing].

Journal: Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery 20040501

Title: The role of protein tyrosine kinases in CYP1A1 induction by omeprazole and thiabendazole in rat hepatocytes.

Journal: Life sciences 20040319

Title: Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs.

Journal: Blood 20040301

Title: Examination of the signal transduction pathways involved in matrix metalloproteinases-2 in human pulp cells.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20040301

Title: Inactivation of ERK accelerates erythroid differentiation of K562 cells induced by herbimycin A and STI571 while activation of MEK1 interferes with it.

Journal: Molecular and cellular biochemistry 20040301

Title: Modulation of dexamethasone-induced thymocyte apoptosis by heat-shock protein 90-binding agents.

Journal: The Bulletin of Tokyo Dental College 20040201

Title: Total synthesis of herbimycin A.

Journal: Organic letters 20040108

Title: Urokinase receptor mRNA stability involves tyrosine phosphorylation in lung epithelial cells.

Journal: American journal of respiratory cell and molecular biology 20040101

Title: Pyrazolo pyrimidine-type inhibitors of SRC family tyrosine kinases promote ovarian steroid-induced differentiation of human endometrial stromal cells in vitro.

Journal: Biology of reproduction 20040101

Title: Stimulation of NHE3 in OKP cells by an autocrine mechanism.

Journal: Nephron. Experimental nephrology 20040101

Title: Herbimycin A induces sympathetic neuron survival and protects against hypoxia.

Journal: Neuroreport 20031219

Title: The efficacy of tyrosine kinase inhibitors on human pancreatic cancer cell lines.

Journal: The Journal of surgical research 20031201

Title: Natural product origins of Hsp90 inhibitors.

Journal: Current cancer drug targets 20031001

Title: Glycogen synthase kinase-3 regulates formation of long lamellipodia in human keratinocytes.

Journal: Journal of cell science 20030915

Title: Acute application of TNF stimulates apical 70-pS K+ channels in the thick ascending limb of rat kidney.

Journal: American journal of physiology. Renal physiology 20030901

Title: Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase.

Journal: Circulation research 20030822

Title: Herbimycin A attenuates apoptosis during heat stress in rats.

Journal: European journal of pharmacology 20030801

Title: Initial signaling of the fibronectin receptor (alpha5beta1 integrin) in hepatic stellate cells is independent of tyrosine phosphorylation.

Journal: Journal of hepatology 20030701

Title: Corneal IL-8 expression following adenovirus infection is mediated by c-Src activation in human corneal fibroblasts.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20030615

Title: Bcr-Abl-mediated resistance to apoptosis is independent of constant tyrosine-kinase activity.

Journal: Cell death and differentiation 20030501

Title: Evidence for a role of protein tyrosine kinases in cell death induced by gp120 in CHP100 neuroblastoma cells.

Journal: Toxicology letters 20030404

Title: Oxidative stress-induced cell death of human oral neutrophils.

Journal: American journal of physiology. Cell physiology 20030401

Title: Cyclical mechanical stretch enhances angiopoietin-2 and Tie2 receptor expression in cultured human umbilical vein endothelial cells.

Journal: Clinical science (London, England : 1979) 20030401

Title: Different modulation by Ca2+-activated K+ channel blockers and herbimycin of acetylcholine- and flow-evoked vasodilatation in rat mesenteric small arteries.

Journal: British journal of pharmacology 20030401

Title: Endothelial contraction and monolayer hyperpermeability are regulated by Src kinase.

Journal: American journal of physiology. Heart and circulatory physiology 20030301

Title: Tetanus toxin abolishes exocytosis of ROMK1 induced by inhibition of protein tyrosine kinase.

Journal: American journal of physiology. Renal physiology 20030301

Title: Genistein inhibits herbimycin A-induced over-expression of inducible heat shock protein 70 kDa.

Journal: Molecular and cellular biochemistry 20030301

Title: Activation of the MAP kinase cascade by exogenous calcium-sensing receptor.

Journal: Molecular and cellular endocrinology 20030227

Title: Pharmacological induction of HSP27 attenuates intimal hyperplasia in vivo.

Journal: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20030101

Title: Src tyrosine kinase but not activated Ras augments sensitivity to taxanes through apoptosis in human adenocarcinoma cells.

Journal: Anticancer research 20030101

Title: Tyrosine phosphorylation is involved in Ca(2+)entry in human gingival fibroblasts.

Journal: Cell biology international 20030101

Title: Epidermal growth factor regulates Ca2+ uptake in primary cultured renal proximal tubule cells: involvement of cAMP, PKC and cPLA2.

Journal: Kidney & blood pressure research 20030101

Title: Depolymerization of actin filament by cytochalasin E induces interleukin-8 production and up-regulates CD54 in the HeLa epithelial cell line.

Journal: Microbiology and immunology 20030101

Title: Activation of mitogen-activated protein kinases during granulocyte apoptosis in patients with severe sepsis.

Journal: Shock (Augusta, Ga.) 20021101

Title: Cyclic mechanical stretch augments prostacyclin production in cultured human uterine myometrial cells from pregnant women: possible involvement of up-regulation of prostacyclin synthase expression.

Journal: The Journal of clinical endocrinology and metabolism 20021101

Title: Ara-C- and daunorubicin-induced recruitment of Lyn in sphingomyelinase-enriched membrane rafts.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001

Title: Down-regulation of cell surface insulin receptor and insulin receptor substrate-1 phosphorylation by inhibitor of 90-kDa heat-shock protein family: endoplasmic reticulum retention of monomeric insulin receptor precursor with calnexin in adrenal chromaffin cells.

Journal: Molecular pharmacology 20021001

Title: Both tissue inhibitors of metalloproteinases-1 (TIMP-1) and TIMP-2 activate Ras but through different pathways.

Journal: Biochemical and biophysical research communications 20020809

Title: Urokinase induces its own expression in Beas2B lung epithelial cells.

Journal: American journal of physiology. Lung cellular and molecular physiology 20020801

Title: Role of pp60(c-src) and p(44/42) MAPK in ANG II-induced contraction of rat tonic gastrointestinal smooth muscles.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20020801

Title: Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors.

Journal: Leukemia 20020801

Title: Inhibition of protein kinases A and C demonstrates dual modes of response in human eosinophils stimulated with platelet-activating factor.

Journal: The Journal of allergy and clinical immunology 20020801

Title: FLT3 in human hematologic malignancies.

Journal: Leukemia & lymphoma 20020801

Title: The role of Aktand RAFTK in beta1 integrin mediated survival of precursor B-acute lymphoblastic leukemia cells.

Journal: Leukemia & lymphoma 20020801

Title: A tyrosine kinase regulates propofol-induced modulation of the beta-subunit of the GABA(A) receptor and release of intracellular calcium in cortical rat neurones.

Journal: Acta physiologica Scandinavica 20020701

Title: E-selectin modulates the malignant properties of T84 colon carcinoma cells.

Journal: Biochemical and biophysical research communications 20020510

Title: Regulation of an ERG K+ current by Src tyrosine kinase.

Journal: The Journal of biological chemistry 20020419

Title: Role of the cytoskeleton in mediating effect of vasopressin and herbimycin A on secretory K channels in CCD.

Journal: American journal of physiology. Renal physiology 20020401

Title: Soluble fibrinogen modulates neutrophil functionality through the activation of an extracellular signal-regulated kinase-dependent pathway.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20020401

Title: Phosphatidylinositol 3-kinase activity is required for epidermal growth factor to suppress proteolysis.

Journal: Journal of the American Society of Nephrology : JASN 20020401

Title: Merosin-integrin promotion of skeletal myofiber cell survival: Differentiation state-distinct involvement of p60Fyn tyrosine kinase and p38alpha stress-activated MAP kinase.

Journal: Journal of cellular physiology 20020401

Title: A proteasome inhibitor confers cardioprotection.

Journal: Cardiovascular research 20020401

Title: HSP90 inhibitors alter capsaicin- and ATP-induced currents in rat dorsal root ganglion neurons.

Journal: Neuroreport 20020325

Title: Involvement of protein tyrosine phosphorylation and reduction of cellular sulfhydryl groups in cell death induced by 1' -acetoxychavicol acetate in Ehrlich ascites tumor cells.

Journal: Chemico-biological interactions 20020220

Title: Src tyrosine kinase augments taxotere-induced apoptosis through enhanced expression and phosphorylation of Bcl-2.

Journal: British journal of cancer 20020201

Title: Model of inhibition of the NPM-ALK kinase activity by herbimycin A.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020101

Title: Vanadate increases glucocorticoid receptor-mediated gene expression: a novel mechanism for potentiation of a steroid receptor.

Journal: The Journal of steroid biochemistry and molecular biology 20020101

Title: Inhibitory effect of Carthamus tinctorius L. seed extracts on bone resorption mediated by tyrosine kinase, COX-2 (cyclooxygenase) and PG (prostaglandin) E2.

Journal: The American journal of Chinese medicine 20020101

Title: Albumin induces NF-kappaB expression in human proximal tubule-derived cells (IHKE-1).

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20020101

Title: TNF-alpha suppresses bone sialoprotein (BSP) expression in ROS17/2.8 cells.

Journal: Journal of cellular biochemistry 20020101

Title: Cytoprotection against thermal injury: evaluation of herbimycin A by cell viability and cDNA arrays.

Journal: The pharmacogenomics journal 20020101

Title: Role of tyrosine phosphorylation in ligand-independent sequestration of CXCR4 in human primary monocytes-macrophages.

Journal: The Journal of biological chemistry 20011228

Title: Macrophage migration inhibitory factor as a redox-sensitive cytokine in cardiac myocytes.

Journal: Cardiovascular research 20011201

Title: Activation of p38 mitogen-activated protein kinases by endothelin and noradrenaline in small arteries, regulation by calcium influx and tyrosine kinases, and their role in contraction.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20011201

Title: Cyclic stretch enhances the expression and activity of coronary endothelium-derived hyperpolarizing factor synthase.

Journal: Hypertension (Dallas, Tex. : 1979) 20011201

Title: Tissue inhibitor of metalloproteinases 1 and 2 directly stimulate the bone-resorbing activity of isolated mature osteoclasts.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20011201

Title: Tyrosine phosphorylation of the catalytic subunit p110 of phosphatidylinositol-3 kinase induced by HMG-CoA reductase inhibitor inhibits its kinase activity in L6 myoblasts.

Journal: FEBS letters 20011109

Title: Involvement of ADAM9 in multinucleated giant cell formation of blood monocytes.

Journal: Cellular immunology 20011101

Title: Effects of protein tyrosine kinase and protein tyrosine phosphatase on apical K(+) channels in the TAL.

Journal: American journal of physiology. Cell physiology 20011001

Title: PDGF-BB-mediated activation of p42(MAPK) is independent of PDGF beta-receptor tyrosine phosphorylation.

Journal: American journal of physiology. Lung cellular and molecular physiology 20011001

Title: p73 is a growth-regulated protein in vascular smooth muscle cells and is present at high levels in human atherosclerotic plaque.

Journal: Cellular signalling 20011001

Title: Phosphorylation-induced activation of tilapia nonspecific cytotoxic cells by serum cytokines.

Journal: Diseases of aquatic organisms 20010912

Title: Inhibition of tyrosine kinase activity induces caspase-dependent apoptosis in anaplastic large cell lymphoma with NPM-ALK (p80) fusion protein.

Journal: Experimental hematology 20010901

Title: Effect of dietary K intake on apical small-conductance K channel in CCD: role of protein tyrosine kinase.

Journal: American journal of physiology. Renal physiology 20010801

Title: Regulation of MARCKS and MARCKS-related protein expression in BV-2 microglial cells in response to lipopolysaccharide.

Journal: Journal of neurochemistry 20010801

Title: FLT3 tyrosine kinase as a target molecule for selective antileukemia therapy.

Journal: Cancer chemotherapy and pharmacology 20010801

Title: Herbimycin, a tyrosine kinase inhibitor with Src selectivity, reduces progesterone and estradiol secretion by human granulosa cells.

Journal: Endocrine 20010801

Title: Cholecystokinin activation of 70-kDa S6 kinase in exocrine pancreas.

Journal: Digestive diseases and sciences 20010701

Title: Albumin in the mg/l-range activates NF-kappaB in renal proximal tubule-derived cell lines via tyrosine kinases and protein kinase C.

Journal: European journal of medical research 20010628

Title: The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner.

Journal: Oncogene 20010607

Title: Modulation of excitability in Aplysia tail sensory neurons by tyrosine kinases.

Journal: Journal of neurophysiology 20010601

Title: Insulin-like growth factor-binding protein 1 stimulates human trophoblast migration by signaling through alpha 5 beta 1 integrin via mitogen-activated protein Kinase pathway.

Journal: The Journal of clinical endocrinology and metabolism 20010601

Title: c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation.

Journal: The Journal of biological chemistry 20010511

Title: Involvement of Rho-kinase and tyrosine kinase in hypotonic stress-induced ATP release in bovine aortic endothelial cells.

Journal: The Journal of physiology 20010501

Title: Signal transduction via both human low-affinity IgG Fc receptors, Fc gamma RIIa and Fc gamma RIIIb, depends on the activity of different families of intracellular kinases.

Journal: Immunobiology 20010501

Title: Engagement of CD147 molecule-induced cell aggregation through the activation of protein kinases and reorganization of the cytoskeleton.

Journal: Immunobiology 20010501

Title: Requirement of chondroitin sulfate/dermatan sulfate recognition in midkine-dependent migration of macrophages.

Journal: Glycoconjugate journal 20010501

Title: Assessment of the effects of tyrosine protein kinase inhibitors.

Journal: Current protocols in immunology 20010501

Title: Possible participation of a JAK2 signaling pathway in recombinant rat interleukin-5-induced prolongation of rat eosinophil survival.

Journal: Biochimica et biophysica acta 20010430

Title: UCS15A, a non-kinase inhibitor of Src signal transduction.

Journal: Oncogene 20010419

Title: Antibody binding to a conformation-dependent epitope induces L-selectin association with the detergent-resistant cytoskeleton.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20010415

Title: Differential requirements for ERK1/2 and P38 MAPK activation by thrombin in T cells. Role of P59Fyn and PKCepsilon.

Journal: Oncogene 20010412

Title: Mitogenic effect of oxidized low-density lipoprotein on vascular smooth muscle cells mediated by activation of Ras/Raf/MEK/MAPK pathway.

Journal: British journal of pharmacology 20010401

Title: Mechanisms of thrombin-induced MAPK activation associated with cell proliferation in human cultured tracheal smooth muscle cells.

Journal: Cellular signalling 20010401

Title: Protein tyrosine kinase regulates FAS-mediated apoptosis in human BCG-infected monocytes.

Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20010401

Title: Regulation of ROMK1 channels by protein-tyrosine kinase and -tyrosine phosphatase.

Journal: The Journal of biological chemistry 20010309

Title: Differential expression of Hox A5 in human colon cancer cell differentiation: a quantitative study using real-time RT-PCR.

Journal: International journal of oncology 20010301

Title: Src tyrosine kinases and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases mediate pressure-induced c-fos expression in cannulated rat mesenteric small arteries.

Journal: Hypertension (Dallas, Tex. : 1979) 20010301

Title: Synergistic inhibition of the glucocorticoid receptor by radicicol and benzoquinone ansamycins.

Journal: Biological chemistry 20010301

Title: The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner.

Journal: The Journal of biological chemistry 20010216

Title: Up-regulation of urokinase-type plasminogen activator by insulin-like growth factor-I depends upon phosphatidylinositol-3 kinase and mitogen-activated protein kinase kinase.

Journal: Cancer research 20010215

Title: Upregulation of angiotensin-converting enzyme by vascular endothelial growth factor.

Journal: American journal of physiology. Heart and circulatory physiology 20010201

Title: PTH stimulates PLCbeta and PLCgamma isoenzymes in rat enterocytes: influence of ageing.

Journal: Cellular signalling 20010201

Title: Outside-in signaling pathway linked to CD146 engagement in human endothelial cells.

Journal: The Journal of biological chemistry 20010112

Title: Relationship between flow rate and NO production in postnatal mesenteric arteries.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20010101

Title: Involvement of a herbimycin A-sensitive protein tyrosine kinase in extracellular action of HIV-1 Nef.

Journal: Immunology letters 20010101

Title: Differential effects of protein tyrosine kinase inhibitors on interferon-gamma-induction of major histocompatibility complex class II and intercellular adhesion molecule-1 expression in human corneal epithelial cells.

Journal: Japanese journal of ophthalmology 20010101

Title: Molecular mechanisms by which iron induces nitric oxide synthesis in cultured proximal tubule cells.

Journal: Experimental nephrology 20010101

Title: Protein tyrosine kinase-dependent regulation of adenylate cyclase and phosphatidylinositol 3-kinase activates the expression of glial fibrillary acidic protein upon induction of differentiation in rat c6 glioma.

Journal: Cell biology international 20010101

Title: Cepharanthine activates caspases and induces apoptosis in Jurkat and K562 human leukemia cell lines.

Journal: Journal of cellular biochemistry 20010101

Title: [Involvement of regulating the phosphatidylinositol 3-kinase signaling pathway in the process of herbimycin A-induced erythroid cell differentiation in the K562 erythroleukemia cell line].

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20010101

Title: Selective involvement of reactive oxygen intermediates in platelet-activating factor-mediated activation of NF-kappaB.

Journal: Inflammation 20001001

Title: Synergistic activation of NF-kappab and inducible isoform of nitric oxide synthase induction by interferon-gamma and tumor necrosis factor-alpha in INS-1 cells.

Journal: Journal of cellular physiology 20000701

Title: Differential induction of tumor necrosis factor alpha and manganese superoxide dismutase by endotoxin in human monocytes: role of protein tyrosine kinase, mitogen-activated protein kinase, and nuclear factor kappaB.

Journal: Journal of cellular physiology 20000301

Title: Transforming growth factor(beta)-mediated corneal myofibroblast differentiation requires actin and fibronectin assembly.

Journal: Investigative ophthalmology & visual science 19990801

Title: Involvement of the tyrosine phosphorylation pathway in induction of human heme oxygenase-1 by hemin, sodium arsenite, and cadmium chloride.

Journal: Journal of biochemistry 19980901

Title: Inhibition of HIV-1 Tat-mediated transactivation by quinacrine and chloroquine.

Journal: Biochemical and biophysical research communications 19960904

Title: Activation of phospholipase D is tightly coupled to the phagocytosis of Mycobacterium tuberculosis or opsonized zymosan by human macrophages.

Journal: The Journal of experimental medicine 19960801

Title: Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1.

Journal: The Biochemical journal 19951201

Title: Mechanisms controlling nitric oxide synthesis in osteoblasts.

Journal: Molecular and cellular endocrinology 19950101

Title: Specific inhibition of cytoplasmic protein tyrosine kinases by herbimycin A in vitro.

Journal: Biochemical pharmacology 19911009

Title: Use and selectivity of herbimycin A as inhibitor of protein-tyrosine kinases.

Journal: Methods in enzymology 19910101

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Tags:70563-58-5 Molecular Formula|70563-58-5 MDL|70563-58-5 SMILES|70563-58-5 HERBIMYCIN A