Home Other Building Blocks 78281-02-4
78281-02-4,MFCD08435942
Catalog No.:AA001DL9

78281-02-4 | 2,5-Cyclohexadien-1-one, 2,4-di-β-D-glucopyranosyl-3,4,5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl]-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99%(HPLC)powder
in stock  
$40.00   $28.00
- +
5mg
99%(HPLC)powder
in stock  
$81.00   $57.00
- +
10mg
99%(HPLC)powder
in stock  
$158.00   $110.00
- +
20mg
99
in stock  
$286.00   $200.00
- +
25mg
99%(HPLC)powder
in stock  
$293.00   $205.00
- +
50mg
99%(HPLC)powder
in stock  
$512.00   $358.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001DL9
Chemical Name:
2,5-Cyclohexadien-1-one, 2,4-di-β-D-glucopyranosyl-3,4,5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl]-
CAS Number:
78281-02-4
Molecular Formula:
C27H32O16
Molecular Weight:
612.5334
MDL Number:
MFCD08435942
SMILES:
OC[C@H]1O[C@H]([C@@H]([C@H]([C@@H]1O)O)O)C1=C(O)C(C(=C(C1=O)C(=O)/C=C/c1ccc(cc1)O)O)(O)[C@@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O
Properties
Computed Properties
 
Complexity:
1160  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
43  
Hydrogen Bond Acceptor Count:
16  
Hydrogen Bond Donor Count:
12  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-3.5  

Downstream Synthesis Route

[1]Onodera,Jun-ichi;Obara,Heitaro;Osone,Masahide;Maruyama,Yasunobu;Sato,Shingo[ChemistryLetters,1981,p.433-436]

Literature

Title: Hydroxysafflor yellow A of Carthamus tinctorius attenuates lung injury of aged rats exposed to gasoline engine exhaust by down-regulating platelet activation.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20140215

Title: Neuroprotection of hydroxysafflor yellow A in the transient focal ischemia: inhibition of protein oxidation/nitration, 12/15-lipoxygenase and blood-brain barrier disruption.

Journal: Brain research 20120914

Title: Hydroxysafflor yellow A induces apoptosis in activated hepatic stellate cells through ERK1/2 pathway in vitro.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120815

Title: Effects of hydroxy safflower yellow-A on tumor capillary angiogenesis in transplanted human gastric adenocarcinoma BGC-823 tumors in nude mice.

Journal: Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 20120601

Title: The effects of hydroxysafflor yellow A on blood pressure and cardiac function.

Journal: Journal of ethnopharmacology 20120215

Title: Taoren-Honghua herb pair and its main components promoting blood circulation through influencing on hemorheology, plasma coagulation and platelet aggregation.

Journal: Journal of ethnopharmacology 20120131

Title: Hydroxysafflor yellow A alleviates early inflammatory response of bleomycin-induced mice lung injury.

Journal: Biological & pharmaceutical bulletin 20120101

Title: Hydroxysafflor yellow A attenuates carbon tetrachloride-induced hepatic fibrosis in rats by inhibiting ERK5 signaling.

Journal: The American journal of Chinese medicine 20120101

Title: Inhibitory effects of hydroxysafflor yellow A on the formation of advanced glycation end products in vitro.

Journal: Biological & pharmaceutical bulletin 20120101

Title: Hydroxysafflor yellow A protects PC12 cells against the apoptosis induced by oxygen and glucose deprivation.

Journal: Cellular and molecular neurobiology 20111101

Title: [Studies on pharmacokinetics of hydroxysafflor yellow A in Carthamus tinctorius and its compound preparation in rat].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110801

Title: Hydroxysafflor yellow A protects against chronic carbon tetrachloride-induced liver fibrosis.

Journal: European journal of pharmacology 20110625

Title: Identification and mapping of a novel hydroxysafflor yellow A (HSYA) biosynthetic gene in Carthamus tinctorius.

Journal: Biochemical genetics 20110601

Title: [Protective effect of hydroxysafflor yellow A on endothelial cell injury induced by lipopolysaccharide].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110601

Title: [HPLC determination of four components in Tibetan medicine Dangzuo of different Tibetan regions].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110401

Title: [Inhibitory effect of hydroxysafflor yellow A against PMN activation induced by LPS].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20110201

Title: A strategy for detecting optimal ratio of cardioprotection-dependent three compounds as quality control of guan-xin-er-hao formula.

Journal: Journal of ethnopharmacology 20110127

Title: Identification of the major constituents in Xuebijing injection by HPLC-ESI-MS.

Journal: Phytochemical analysis : PCA 20110101

Title: Enhanced effect and mechanism of water-in-oil microemulsion as an oral delivery system of hydroxysafflor yellow A.

Journal: International journal of nanomedicine 20110101

Title: The ability of hydroxysafflor yellow a to attenuate lipopolysaccharide-induced pulmonary inflammatory injury in mice.

Journal: Phytotherapy research : PTR 20101201

Title: Neuroprotective effects of hydroxysafflor yellow A against excitotoxic neuronal death partially through down-regulation of NR2B-containing NMDA receptors.

Journal: Neurochemical research 20100901

Title: [Simultaneous determination of multicomponent in Xuefuzhuyu granule with different UV-wavelength by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100801

Title: Hydroxysafflor Yellow A suppresses thrombin generation and inflammatory responses following focal cerebral ischemia-reperfusion in rats.

Journal: Bioorganic & medicinal chemistry letters 20100715

Title: [Protective effect of hydroxysafflor yellow A against acute lung injury induced by oleic acid and lipopolysaccharide in rats].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100701

Title: Pharmacokinetic comparisons of hydroxysafflower yellow A in normal and blood stasis syndrome rats.

Journal: Journal of ethnopharmacology 20100504

Title: The mechanisms for enhanced oral absorption of hydroxysafflor yellow A by chuanxiong volatile oil.

Journal: Planta medica 20100501

Title: Effects of hydroxysafflor yellow A on the experimental traumatic brain injury in rats.

Journal: Journal of Asian natural products research 20100301

Title: Effects of hydroxysafflor yellow A in the attenuation of MPTP neurotoxicity in mice.

Journal: Neurochemical research 20100101

Title: Hydroxysafflor Yellow A protects spinal cords from ischemia/reperfusion injury in rabbits.

Journal: BMC neuroscience 20100101

Title: [Research on technological process of two-pot countercurrent extraction of hydroxysafflor yellow A].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091101

Title: Pharmacokinetic properties of hydroxysafflor yellow A in healthy Chinese female volunteers.

Journal: Journal of ethnopharmacology 20090730

Title: [Effects of hydroxy safflor yellow A on blood vessel and mRNA expression with VEGF and bFGF of transplantation tumor with gastric adenocarcinoma cell line BGC-823 in nude mice].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090301

Title: Effect of Guanxin No.2 decoction on gene expression in different areas of the myocardial infarcted heart of rats using microarray technology.

Journal: The Journal of pharmacy and pharmacology 20090201

Title: Effect of Hydroxysafflor yellow A on human umbilical vein endothelial cells under hypoxia.

Journal: Vascular pharmacology 20090101

Title: A rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of hydroxysafflor yellow A in human plasma: application to a pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081201

Title: [Quality evaluation of Flos Carthami].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081101

Title: Cardioprotective effects of hydroxysafflor yellow A on diabetic cardiac insufficiency attributed to up-regulation of the expression of intracellular calcium handling proteins of sarcoplasmic reticulum in rats.

Journal: Phytotherapy research : PTR 20080801

Title: Hydroxysafflor yellow A enhances survival of vascular endothelial cells under hypoxia via upregulation of the HIF-1 alpha-VEGF pathway and regulation of Bcl-2/Bax.

Journal: Journal of cardiovascular pharmacology 20080801

Title: Hydroxysafflor yellow A protects neuron against hypoxia injury and suppresses inflammatory responses following focal ischemia reperfusion in rats.

Journal: Archives of pharmacal research 20080801

Title: Enhancing effect of Labrafac Lipophile WL 1349 on oral bioavailability of hydroxysafflor yellow A in rats.

Journal: International journal of pharmaceutics 20080624

Title: [Inhibitory action of hydroxysafflor yellow A on inflammatory signal transduction pathway related factors in rats with cerebral cortex ischemia].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080601

Title: [Hydroxysafflor yellow A up-regulates HIF-1alpha via inhibition of VHL and p53 in Eahy 926 cell line exposed to hypoxia].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080501

Title: Characterization of C-glycosyl quinochalcones in Carthamus tinctorius L. by ultraperformance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20080401

Title: Evidence that hydroxysafflor yellow A protects the heart against ischaemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening.

Journal: Clinical and experimental pharmacology & physiology 20080201

Title: Protective effects of hydroxysafflor yellow A on acute and chronic congestive cardiac failure mediated by reducing ET-1, NOS and oxidative stress in rats.

Journal: The Journal of pharmacy and pharmacology 20080101

Title: Hydroxysafflor yellow A inhibits rat brain mitochondrial permeability transition pores by a free radical scavenging action.

Journal: Pharmacology 20080101

Title: Simultaneous determination of hydroxysafflor yellow A and ferulic acid in rat plasma after oral administration of the co-extractum of Rhizoma chuanxiong and Flos Carthami by HPLC-diode array detector.

Journal: Biomedical chromatography : BMC 20070801

Title: Preparation of the traditional Chinese medicine compound recipe Shuxiong sustained-release capsules by multiparticulate time-controlled explosion technology.

Journal: Die Pharmazie 20070501

Title: Determination of hydroxysafflor yellow A in rat plasma and tissues by high-performance liquid chromatography after oral administration of safflower extract or safflor yellow.

Journal: Biomedical chromatography : BMC 20070301

Title: [Determination of safflor yellow A by RP-HPLC and resources quality comparison in Carthamus tinctorius].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060801

Title: [Preparation of Shuxiong micropellets by centrifugal granulation technology].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060701

Title: Pharmacokinetics and excretion of hydroxysafflor yellow A, a potent neuroprotective agent from safflower, in rats and dogs.

Journal: Planta medica 20060401

Title: Simultaneous determination of components in preparation Naodesheng injection by high performance liquid chromatograph-atmospheric pressure chemical ionization mass spectrometry (HPLC-MS/APCI).

Journal: Chemical & pharmaceutical bulletin 20060401

Title: [Protective effect of hydroxysafflor yellow A on experimental cerebral ischemia in rats].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20051201

Title: Hydroxysafflor yellow A protects rat brains against ischemia-reperfusion injury by antioxidant action.

Journal: Neuroscience letters 20050923

Title: Therapeutic effects of hydroxysafflor yellow A on focal cerebral ischemic injury in rats and its primary mechanisms.

Journal: Journal of Asian natural products research 20050801

Title: The subchronic toxicity of hydroxysafflor yellow A of 90 days repeatedly intraperitoneal injections in rats.

Journal: Toxicology 20041015

Title: [Protective effect of hydroxysafflor yellow A against rat cortex mitochondrial injuries induced by cerebral ischemia].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20041001

Title: [Establishment of chromatographic fingerprint and quality assessment of Carthamus tinctorius L. by high performance liquid chromatography].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040301

Title: [Study on distribution of safflor yellow A in tissues of mice].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040301

Title: Neuroprotective effects of hydroxysafflor yellow A: in vivo and in vitro studies.

Journal: Planta medica 20030501

Title: [Antagonistic effect of hydroxysafflor yellow A on the platelet activating factor receptor].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020901

Title: Yang G, et al. Hydroxysafflor yellow A inhibits lipopolysaccharide-induced proliferation and migration of vascular smooth muscle cells via Toll-like receptor-4 pathway. Int J Clin Exp Med. 2015 Apr 15;8(4):5295-302.

Title: Zhu HJ, et al. Hydroxysafflor yellow A (HYSA) inhibited the proliferation and differentiation of 3T3-L1 preadipocytes. Cytotechnology. 2015 Mar 7.

Title: He Y, et al. Protective effects of hydroxysafflor yellow A (HSYA) on alcohol-induced liver injury in rats. J Physiol Biochem. 2015 Mar;71(1):69-78.

Title: Jin M, et al. Hydroxysafflor yellow A attenuate lipopolysaccharide-induced endothelium inflammatory injury. Chin J Integr Med. 2015 May 27.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 78281-02-4
Tags:78281-02-4 Molecular Formula|78281-02-4 MDL|78281-02-4 SMILES|78281-02-4 2,5-Cyclohexadien-1-one, 2,4-di-β-D-glucopyranosyl-3,4,5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl]-