Title: Optimization of a potent class of arylamide colony-stimulating factor-1 receptor inhibitors leading to anti-inflammatory clinical candidate 4-cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141).
Journal: Journal of medicinal chemistry 20111124
Title: Potent 2'-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents.
Journal: Bioorganic & medicinal chemistry letters 20071115
Title: Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors.
Journal: The Journal of biological chemistry 20070209
Title: Illig CR, et al. Discovery of novel FMS kinase inhibitors as anti-inflammatory agents. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1642-8.
