Home Other Building Blocks 81377-02-8
81377-02-8,MFCD00872233
Catalog No.:AA00G321

81377-02-8 | SEGLITIDE

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1mg
>98.00%
3 weeks  
$840.00   $588.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00G321
Chemical Name:
SEGLITIDE
CAS Number:
81377-02-8
Molecular Formula:
C44H56N8O7
Molecular Weight:
808.9648
MDL Number:
MFCD00872233
SMILES:
NCCCC[C@@H]1NC(=O)[C@H](NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N(C(=O)[C@@H](NC(=O)[C@@H](NC1=O)C(C)C)Cc1ccccc1)C)C)Cc1c[nH]c2c1cccc2
Properties
Computed Properties
 
Complexity:
1430  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
59  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
8  
Rotatable Bond Count:
11  
XLogP3:
3.9  

Literature

Title: Mechanisms underlying modulation of monocarboxylate transporter 1 (MCT1) by somatostatin in human intestinal epithelial cells.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20091101

Title: Inhibitory effect of somatostatin-14 on L-type voltage-gated calcium channels in cultured cone photoreceptors requires intracellular calcium.

Journal: Journal of neurophysiology 20090901

Title: Antidepressants influence somatostatin levels and receptor pharmacology in brain.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090301

Title: Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

Journal: Journal of medicinal chemistry 20080612

Title: Microinjection of exogenous somatostatin in the dorsal vagal complex inhibits pancreatic secretion via somatostatin receptor-2 in rats.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20070301

Title: Porcine somatostatin receptor 2 displays typical pharmacological sst2 features but unique dynamics of homodimerization and internalization.

Journal: Endocrinology 20070101

Title: Somatostatin receptors in the ventral pallidum/substantia innominata modulate rat locomotor activity.

Journal: Psychopharmacology 20050901

Title: Somatostatin receptors (sst2) are coupled to Go and modulate GTPase activity in the rabbit retina.

Journal: Journal of neurochemistry 20030201

Title: Cloning, expression and pharmacological characterisation of the mouse somatostatin sst(5) receptor.

Journal: Neuropharmacology 20000608

Title: Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studies.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19991101

Title: Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and structure-activity relationships of thioureas.

Journal: Journal of medicinal chemistry 19981119

Title: Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19980901

Title: [125I][Tyr3]octreotide labels human somatostatin sst2 and sst5 receptors.

Journal: European journal of pharmacology 19980508

Title: [125I]Tyr10-cortistatin14 labels all five somatostatin receptors.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19980501

Title: The elucidation of somatostatin receptor functions: a current view.

Journal: Reviews of physiology, biochemistry and pharmacology 19980101

Title: Differential expression of multiple somatostatin receptors in the rat cerebellum during development.

Journal: Journal of neurochemistry 19970601

Title: Binding properties of somatostatin receptor subtypes.

Journal: Metabolism: clinical and experimental 19960801

Title: Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5).

Journal: Endocrinology 19941201

Title: Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides.

Journal: Molecular pharmacology 19930601

Title: Somatostatin centrally inhibits vasopressin secretion during haemorrhage.

Journal: Brain research 19871208

Title: Inhibition of neurotensin release by a cyclic hexapeptide analog of somatostatin.

Journal: Peptides 19850101

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