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88898-17-3,MFCD00076228
Catalog No.:AA01E9KC

88898-17-3 | Atrial Natriuretic Factor (1-28) (mouse, rabbit, rat) H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide bond)

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1mg
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5mg
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  • Technical Information
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Technical Information
Catalog Number:
AA01E9KC
Chemical Name:
Atrial Natriuretic Factor (1-28) (mouse, rabbit, rat) H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide bond)
CAS Number:
88898-17-3
Molecular Formula:
C128H205N45O39S2
Molecular Weight:
3062.4054
MDL Number:
MFCD00076228
SMILES:
CC[C@@H]([C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCCNC(=N)N)[C@H](CC)C)C)CCC(=O)N)CO)CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)O)CCCNC(=N)N)Cc1ccccc1)CO)CC(=O)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)N)CC(C)C)CCCNC(=N)N)CCCNC(=N)N)CO)CO)C
Properties
Computed Properties
 
Complexity:
6950  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
25  
Heavy Atom Count:
214  
Hydrogen Bond Acceptor Count:
47  
Hydrogen Bond Donor Count:
53  
Rotatable Bond Count:
74  
XLogP3:
-14.2  

Literature

Title: Polydatin prevents hypertrophy in phenylephrine induced neonatal mouse cardiomyocytes and pressure-overload mouse models.

Journal: European journal of pharmacology 20150105

Title: The functional properties of nephronectin: an adhesion molecule for cardiac tissue engineering.

Journal: Biomaterials 20120601

Title: Action of ANP on the nongenomic dose-dependent biphasic effect of aldosterone on NHE1 in proximal S3 segment.

Journal: The Journal of steroid biochemistry and molecular biology 20120201

Title: Identification of a possible role for atrial natriuretic peptide in MDMA-induced hyperthermia.

Journal: Toxicology letters 20111010

Title: Caveolae are essential for angiotensin II type 1 receptor-mediated ANP secretion.

Journal: Peptides 20110701

Title: [Effect of miRNA-199a on rat cardiac hypertrophy].

Journal: Zhonghua xin xue guan bing za zhi 20110501

Title: Angiotensin-(1-7) attenuates hyposmolarity-induced ANP secretion via the Na+-K+ pump.

Journal: Peptides 20100901

Title: Heme arginate therapy enhanced adiponectin and atrial natriuretic peptide, but abated endothelin-1 with attenuation of kidney histopathological lesions in mineralocorticoid-induced hypertension.

Journal: The Journal of pharmacology and experimental therapeutics 20100701

Title: Apocynin attenuates pressure overload-induced cardiac hypertrophy in rats by reducing levels of reactive oxygen species.

Journal: Canadian journal of physiology and pharmacology 20100701

Title: Central nitrergic system regulation of neuroendocrine secretion, fluid intake and blood pressure induced by angiotensin-II.

Journal: Behavioral and brain functions : BBF 20100101

Title: [Atrial natriuratic peptide and experimental vasorenal hypertension in rats].

Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia 20100101

Title: Krüppel-like factor 4 mediates histone deacetylase inhibitor-induced prevention of cardiac hypertrophy.

Journal: Journal of molecular and cellular cardiology 20091201

Title: Local action of endogenous renal tubular atrial natriuretic peptide.

Journal: Journal of cellular physiology 20090601

Title: Stimulus specific changes of energy metabolism in hypertrophied heart.

Journal: Journal of molecular and cellular cardiology 20090601

Title: Post-ischemic infusion of atrial natriuretic peptide attenuates warm ischemia-reperfusion injury in rat lung.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20090601

Title: Excess of glucocorticoid induces cardiac dysfunction via activating angiotensin II pathway.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20090101

Title: Signaling cascade that mediates endothelial nitric oxide synthase activation induced by atrial natriuretic peptide.

Journal: Regulatory peptides 20081129

Title: L-arginine inhibits isoproterenol-induced cardiac hypertrophy through nitric oxide and polyamine pathways.

Journal: Basic & clinical pharmacology & toxicology 20080801

Title: Regulation of cardiomyocyte hypertrophy in diabetes at the transcriptional level.

Journal: American journal of physiology. Endocrinology and metabolism 20080601

Title: ANP stimulates hepatocyte Ca2+ efflux via plasma membrane recruitment of PKGIalpha.

Journal: Biochemical and biophysical research communications 20080418

Title: Effects of levosimendan on cardiac remodeling and cardiomyocyte apoptosis in hypertensive Dahl/Rapp rats.

Journal: British journal of pharmacology 20070401

Title: Role of a molecular variant of rat atrial natriuretic Peptide gene in vascular remodeling.

Journal: Annals of clinical and laboratory science 20070101

Title: Combined effects of low-dose spironolactone and captopril therapy in a rat model of genetic hypertrophic cardiomyopathy.

Journal: Journal of cardiovascular pharmacology 20061201

Title: Effect of pioglitazone on the expression of inflammatory cytokines in attenuating rat cardiomyocyte hypertrophy.

Journal: Methods and findings in experimental and clinical pharmacology 20061201

Title: In Vivo beta-adrenergic activation of atrial natriuretic factor (ANF) reporter expression.

Journal: Molecular and cellular biochemistry 20061101

Title: PI 3-kinase pathway is responsible for antiapoptotic effects of atrial natriuretic peptide in rat liver transplantation.

Journal: World journal of gastroenterology 20060221

Title: Effects of urocortin II on neonatal rat cardiac myocytes and non-myocytes.

Journal: Peptides 20051201

Title: Role of the integrin-linked kinase/PINCH1/alpha-parvin complex in cardiac myocyte hypertrophy.

Journal: Laboratory investigation; a journal of technical methods and pathology 20051101

Title: Downregulation of the atrial natriuretic peptide/natriuretic peptide receptor-C system in the early stages of diabetic retinopathy in the rat.

Journal: Molecular vision 20050318

Title: Immunocytochemical localization of atrial natriuretic factor (ANF) in rat female reproductive tract: evidence for a potential hormonal regulation.

Journal: Biology of the cell 20020501

Title: Centrally applied atrial natriuretic factor diminishes bile secretion in the rat.

Journal: Regulatory peptides 20011215

Title: Spatial and temporal distribution of atrial natriuretic factor in the rat testis.

Journal: Biology of the cell 20011101

Title: Effect of nitric oxide on basal and stretch-induced release of atrial natriuretic factor (ANF) from isolated perfused rat atria.

Journal: Regulatory peptides 20010420

Title: Human atrial natriuretic factor prevents against norepinephrine-induced acute renal failure in the rat.

Journal: Klinische Wochenschrift 19860101

Title: Kohno M, et al. Angiotensin II stimulates endothelin-1 secretion in cultured rat mesangial cells. Kidney Int. 1992 Oct;42(4):860-6.

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SDS
Tags:88898-17-3 Molecular Formula|88898-17-3 MDL|88898-17-3 SMILES|88898-17-3 Atrial Natriuretic Factor (1-28) (mouse, rabbit, rat) H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide bond)