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90417-38-2,MFCD00942555
Catalog No.:AA003NFN

90417-38-2 | Nu1025

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$45.00   $31.00
- +
5mg
95%
in stock  
$106.00   $74.00
- +
10mg
95%
in stock  
$170.00   $119.00
- +
50mg
95%
in stock  
$566.00   $396.00
- +
100mg
95%
in stock  
$920.00   $644.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA003NFN
Chemical Name:
Nu1025
CAS Number:
90417-38-2
Molecular Formula:
C9H8N2O2
Molecular Weight:
176.1720
MDL Number:
MFCD00942555
SMILES:
Cc1nc2c(O)cccc2c(=O)[nH]1
NSC Number:
696807
Properties
Properties
 
BP:
345.4°C at 760 mmHg  
Form:
Solid  
MP:
253-258°C  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
262  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
0  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
0.3  

Downstream Synthesis Route

[1]Ghosh,SumanKr;Nagarajan,Rajagopal[TetrahedronLetters,2016,vol.57,#38,p.4277-4279]

[2]Griffin;Srinivasan;White;Bowman;Calvert;Curtin;Newell;Golding[PharmaceuticalSciences,1996,vol.2,#1,p.43-47]

[3]Griffin,RogerJ.;Srinivasan,Sheila;Bowman,Karen[JournalofMedicinalChemistry,1998,vol.41,#26,p.5247-5256]

[4]CurrentPatentAssignee:NEWCASTLEUNIVERSITY(UPONTYNE)-US6156739,2000,A

[5]CurrentPatentAssignee:NEWCASTLEUNIVERSITY(UPONTYNE)-US5756510,1998,A

[6]Dickson,BenjaminD.;Wong,WayWua;Wilson,WilliamR.;Hay,MichaelP.[Molecules,2019,vol.24,#8]

[7]Iyer;Dhar[JournalOfScientificandIndustrialResearch,1958,vol.17C,p.193,194]

[8]CurrentPatentAssignee:HSBCHOLDINGSPLC-WO2004/31161,2004,A1Locationinpatent:Page116

[1]IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,1985,vol.24,p.1182-1184

[1]Griffin,RogerJ.;Srinivasan,Sheila;Bowman,Karen[JournalofMedicinalChemistry,1998,vol.41,#26,p.5247-5256]

[2]Griffin,RogerJ.;Srinivasan,Sheila;Bowman,Karen[JournalofMedicinalChemistry,1998,vol.41,#26,p.5247-5256]

[3]Griffin;Srinivasan;White;Bowman;Calvert;Curtin;Newell;Golding[PharmaceuticalSciences,1996,vol.2,#1,p.43-47]

[4]Ghosh,SumanKr;Nagarajan,Rajagopal[TetrahedronLetters,2016,vol.57,#38,p.4277-4279]

[5]Dickson,BenjaminD.;Wong,WayWua;Wilson,WilliamR.;Hay,MichaelP.[Molecules,2019,vol.24,#8]

[1]Griffin,RogerJ.;Srinivasan,Sheila;Bowman,Karen[JournalofMedicinalChemistry,1998,vol.41,#26,p.5247-5256]

[2]Griffin;Srinivasan;White;Bowman;Calvert;Curtin;Newell;Golding[PharmaceuticalSciences,1996,vol.2,#1,p.43-47]

Literature

Title: A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.

Journal: Cell metabolism 20141104

Title: Inhibition of poly(ADP-ribose) polymerase activity affects its subcellular localization and DNA strand break rejoining.

Journal: Acta biochimica Polonica 20090101

Title: Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation.

Journal: Life sciences 20061110

Quotation Request
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SDS
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Tags:90417-38-2 Molecular Formula|90417-38-2 MDL|90417-38-2 SMILES|90417-38-2 Nu1025
Catalog No.: AA003NFN
90417-38-2,MFCD00942555
90417-38-2 | Nu1025
Pack Size： 1mg
Purity： ≥98%
in stock
$45.00 $31.00
Pack Size： 5mg
Purity： 95%
in stock
$106.00 $74.00
Pack Size： 10mg
Purity： 95%
in stock
$170.00 $119.00
Pack Size： 50mg
Purity： 95%
in stock
$566.00 $396.00
Pack Size： 100mg
Purity： 95%
in stock
$920.00 $644.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA003NFN
Chemical Name: Nu1025
CAS Number: 90417-38-2
Molecular Formula: C9H8N2O2
Molecular Weight: 176.1720
MDL Number: MFCD00942555
SMILES: Cc1nc2c(O)cccc2c(=O)[nH]1
NSC Number: 696807
Properties
BP: 345.4°C at 760 mmHg  
Form: Solid  
MP: 253-258°C  
Storage: -20 ℃;  
Complexity: 262  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 13  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 0  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 0.3  
Downstream Synthesis Route
90915-45-0    90417-38-2 

[1]Ghosh,SumanKr;Nagarajan,Rajagopal[TetrahedronLetters,2016,vol.57,#38,p.4277-4279]

[2]Griffin;Srinivasan;White;Bowman;Calvert;Curtin;Newell;Golding[PharmaceuticalSciences,1996,vol.2,#1,p.43-47]

[3]Griffin,RogerJ.;Srinivasan,Sheila;Bowman,Karen[JournalofMedicinalChemistry,1998,vol.41,#26,p.5247-5256]

[4]CurrentPatentAssignee:NEWCASTLEUNIVERSITY(UPONTYNE)-US6156739,2000,A

[5]CurrentPatentAssignee:NEWCASTLEUNIVERSITY(UPONTYNE)-US5756510,1998,A

[6]Dickson,BenjaminD.;Wong,WayWua;Wilson,WilliamR.;Hay,MichaelP.[Molecules,2019,vol.24,#8]

[7]Iyer;Dhar[JournalOfScientificandIndustrialResearch,1958,vol.17C,p.193,194]

[8]CurrentPatentAssignee:HSBCHOLDINGSPLC-WO2004/31161,2004,A1Locationinpatent:Page116

16064-27-0    90417-38-2 

[1]IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,1985,vol.24,p.1182-1184

106782-78-9    90417-38-2 

[1]Griffin,RogerJ.;Srinivasan,Sheila;Bowman,Karen[JournalofMedicinalChemistry,1998,vol.41,#26,p.5247-5256]

[2]Griffin,RogerJ.;Srinivasan,Sheila;Bowman,Karen[JournalofMedicinalChemistry,1998,vol.41,#26,p.5247-5256]

[3]Griffin;Srinivasan;White;Bowman;Calvert;Curtin;Newell;Golding[PharmaceuticalSciences,1996,vol.2,#1,p.43-47]

[4]Ghosh,SumanKr;Nagarajan,Rajagopal[TetrahedronLetters,2016,vol.57,#38,p.4277-4279]

[5]Dickson,BenjaminD.;Wong,WayWua;Wilson,WilliamR.;Hay,MichaelP.[Molecules,2019,vol.24,#8]

172462-98-5    90417-38-2 

[1]Griffin,RogerJ.;Srinivasan,Sheila;Bowman,Karen[JournalofMedicinalChemistry,1998,vol.41,#26,p.5247-5256]

[2]Griffin;Srinivasan;White;Bowman;Calvert;Curtin;Newell;Golding[PharmaceuticalSciences,1996,vol.2,#1,p.43-47]

Literature fold

Title: A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.

Journal: Cell metabolism20141104

Title: Inhibition of poly(ADP-ribose) polymerase activity affects its subcellular localization and DNA strand break rejoining.

Journal: Acta biochimica Polonica20090101

Title: Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation.

Journal: Life sciences20061110

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