[1]Wood,JohnL.;Stoltz,BrianM.;Dietrich,Hans-Jürgen;Pflum,DerekA.;Petsch,DejahT.[JournaloftheAmericanChemicalSociety,1997,vol.119,#41,p.9641-9651]
[2]Wood,JohnL.;Stoltz,BrianM.;Dietrich,Hans-Jürgen[JournaloftheAmericanChemicalSociety,1995,vol.117,#41,p.10413-10414]
[1]Kaneko,Masami;Saito,Yutaka;Saito,Hiromitsu;Matsumoto,Tadashi;Matsuda,Yuzuru;Vaught,JeffryL.;Dionne,CraigA.;Angeles,ThelmaS.;Glicksman,MarcieA.;Neff,NicolaT.;Rotella,DavidP.;Kauer,JamesC.;Mallamo,JohnP.;Hudkins,RobertL.;Murakata,Chikara[JournalofMedicinalChemistry,1997,vol.40,#12,p.1863-1869]
[1]Kino,Mitsutaka;Shono,Kenzo;Nishimura,Tetsuo;Nagamura,Satoru[Bioscience,BiotechnologyandBiochemistry,1998,vol.62,#8,p.1627-1629]
[1]Gingrich,DianeE.;Hudkins,RobertL.[BioorganicandMedicinalChemistryLetters,2002,vol.12,#20,p.2829-2831]Gingrich,DianeE.;Yang,ShiX.;Gessner,GeorgeW.;Angeles,ThelmaS.;Hudkins,RobertL.[JournalofMedicinalChemistry,2005,vol.48,#11,p.3776-3783]
[2]CurrentPatentAssignee:ABBOTTLABORATORIESINC-WO2008/86510,2008,A2Locationinpatent:Page/Pagecolumn5-6
[1]Kinugawa,Masahiko;Mimura,Yukiteru;Masuda,Yoshiaki;Murakata,Chikara;Ogasa,Takehiro;Kasai,Masaji[OrganicProcessResearchandDevelopment,1999,vol.3,#2,p.131-134]
[2]Gingrich,DianeE.;Yang,ShiX.;Gessner,GeorgeW.;Angeles,ThelmaS.;Hudkins,RobertL.[JournalofMedicinalChemistry,2005,vol.48,#11,p.3776-3783]
Title: Methylmercury causes neuronal cell death through the suppression of the TrkA pathway: in vitro and in vivo effects of TrkA pathway activators.
Journal: Toxicology and applied pharmacology 20150201
Title: Type II pyrethroid deltamethrin produces antidepressant-like effects in mice.
Journal: Behavioural brain research 20131115
Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Journal: The Biochemical journal 20130415
Title: Acute and sustained effects of a metabotropic glutamate 5 receptor antagonist in the novelty-suppressed feeding test.
Journal: Behavioural brain research 20121201
Title: Clostridium perfringens alpha-toxin induces the release of IL-8 through a dual pathway via TrkA in A549 cells.
Journal: Biochimica et biophysica acta 20121001
Title: Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF.
Journal: Journal of neurochemistry 20120801
Title: Suppression of hydatidiform molar growth by inhibiting endogenous brain-derived neurotrophic factor/tyrosine kinase B signaling.
Journal: Endocrinology 20120801
Title: Human immunodeficiency virus type 1 alters brain-derived neurotrophic factor processing in neurons.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120711
Title: Interaction between neurotrophin 4 and gonadotrophin in bovine oviducts.
Journal: Theriogenology 20120701
Title: Site-specific synapsin I phosphorylation participates in the expression of post-tetanic potentiation and its enhancement by BDNF.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120425
Title: Nerve growth factor-mediated neuronal plasticity in spinal cord contributes to neonatal maternal separation-induced visceral hypersensitivity in rats.
Journal: European journal of pain (London, England) 20120401
Title: K252a induces anoikis-sensitization with suppression of cellular migration in Epstein-Barr virus (EBV)--associated nasopharyngeal carcinoma cells.
Journal: Investigational new drugs 20120201
Title: Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosin-related kinase A (TrkA) and sortilin protein.
Journal: The Journal of biological chemistry 20120113
Title: In vivo BDNF modulation of hippocampal mossy fiber plasticity induced by high frequency stimulation.
Journal: Hippocampus 20120101
Title: GABA(A) receptor blockade enhances memory consolidation by increasing hippocampal BDNF levels.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120101
Title: Early postnatal exposure of mice to side-steam tobacco smoke increases neuropeptide Y in lung.
Journal: American journal of physiology. Lung cellular and molecular physiology 20120101
Title: Vagal nerve stimulation rapidly activates brain-derived neurotrophic factor receptor TrkB in rat brain.
Journal: PloS one 20120101
Title: Heparanase enhances nerve-growth-factor-induced PC12 cell neuritogenesis via the p38 MAPK pathway.
Journal: The Biochemical journal 20111201
Title: K252a-sensitive protein kinases but not okadaic acid-sensitive protein phosphatases regulate methyl jasmonate-induced cytosolic Ca2+ oscillation in guard cells of Arabidopsis thaliana.
Journal: Journal of plant physiology 20111101
Title: Systemic delivery of bone marrow-derived mesenchymal stromal cells diminishes neuropathology in a mouse model of Krabbe's disease.
Journal: Stem cells (Dayton, Ohio) 20111101
Title: Involvement of NGF in the rat model of persistent muscle pain associated with taut band.
Journal: The journal of pain : official journal of the American Pain Society 20111001
Title: ABCG2 is required to control the sonic hedgehog pathway in side population cells with stem-like properties.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20110901
Title: K252a suppresses neuronal cells apoptosis through inhibiting the translocation of Bax to mitochondria induced by the MLK3/JNK signaling after transient global brain ischemia in rat hippocampal CA1 subregion.
Journal: Journal of receptor and signal transduction research 20110801
Title: AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.
Journal: Chemistry & biology 20110729
Title: Impaired CNS leptin action is implicated in depression associated with obesity.
Journal: Endocrinology 20110701
Title: Upregulation of CREB-mediated transcription enhances both short- and long-term memory.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110615
Title: Activity-dependent transcription of BDNF enhances visual acuity during development.
Journal: Neuron 20110512
Title: Nerve growth factor contribution via transient receptor potential vanilloid 1 to ectopic orofacial pain.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110511
Title: Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110427
Title: Schwann cells promote neurite outgrowth of dorsal root ganglion neurons through secretion of nerve growth factor.
Journal: Indian journal of experimental biology 20110301
Title: A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury.
Journal: The journal of pain : official journal of the American Pain Society 20110101
Title: Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway.
Journal: Brain, behavior, and immunity 20110101
Title: Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor.
Journal: Bioorganic & medicinal chemistry 20110101
Title: Comparison of the specificity of Trk inhibitors in recombinant and neuronal assays.
Journal: Neuropharmacology 20110101
Title: S-adenosyl-L-methionine activates actinorhodin biosynthesis by increasing autophosphorylation of the Ser/Thr protein kinase AfsK in Streptomyces coelicolor A3(2).
Journal: Bioscience, biotechnology, and biochemistry 20110101
Title: Fine-tuning roles of endogenous brain-derived neurotrophic factor, TrkB and sortilin in colorectal cancer cell survival.
Journal: PloS one 20110101
Title: Characterization and functional modification of StaC and RebC, which are involved in the pyrrole oxidation of indolocarbazole biosynthesis.
Journal: Bioscience, biotechnology, and biochemistry 20110101
Title: The interaction between tropomyosin-related kinase B receptors and presynaptic muscarinic receptors modulates transmitter release in adult rodent motor nerve terminals.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20101208
Title: Potent inhibitors of amyloid β fibrillization, 4,5-dianilinophthalimide and staurosporine aglycone, enhance degradation of preformed aggregates of mutant Notch3.
Journal: Biochemical and biophysical research communications 20101105
Title: Elevated BDNF after cocaine withdrawal facilitates LTP in medial prefrontal cortex by suppressing GABA inhibition.
Journal: Neuron 20100909
Title: A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100908
Title: NGF-Dependent activation of TrkA pathway: A mechanism for the neuroprotective effect of troxerutin in D-galactose-treated mice.
Journal: Brain pathology (Zurich, Switzerland) 20100901
Title: Neurotrophic and neuroimmune responses to early-life Pseudomonas aeruginosa infection in rat lungs.
Journal: American journal of physiology. Lung cellular and molecular physiology 20100901
Title: Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor.
Journal: Journal of neurochemistry 20100901
Title: The HGF/c-Met axis synergizes with G-CSF in the mobilization of hematopoietic stem/progenitor cells.
Journal: Stem cells and development 20100801
Title: Differential regulation of axon outgrowth and reinnervation by neurotrophin-3 and neurotrophin-4 in the hippocampal formation.
Journal: Experimental brain research 20100801
Title: Heat shock protein 90 inhibition depletes TrkA levels and signaling in human acute leukemia cells.
Journal: Molecular cancer therapeutics 20100801
Title: Neuronal-driven angiogenesis: role of NGF in retinal neovascularization in an oxygen-induced retinopathy model.
Journal: Investigative ophthalmology & visual science 20100701
Title: Inhibition of brain-derived neurotrophic factor/tyrosine kinase B signaling suppresses choriocarcinoma cell growth.
Journal: Endocrinology 20100701
Title: Biochemical characterization of in vitro phosphorylation and dephosphorylation of the plasma membrane H+-ATPase.
Journal: Plant & cell physiology 20100701
Title: Nerve growth factor regulates the firing patterns and synaptic composition of motoneurons.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100616
Title: Angiostatic effects of K252a, a Trk inhibitor, in murine brain capillary endothelial cells.
Journal: Molecular and cellular biochemistry 20100601
Title: TrkB/BDNF-dependent striatal plasticity and behavior in a genetic model of epilepsy: modulation by valproic acid.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100601
Title: Expression changes of K+-Cl- co-transporter 2 and Na+-K+-Cl- co-transporter1 in mouse trigeminal subnucleus caudalis following pulpal inflammation.
Journal: Brain research bulletin 20100405
Title: Late expression of brain-derived neurotrophic factor in the amygdala is required for persistence of fear memory.
Journal: Neurobiology of learning and memory 20100301
Title: Brain-derived neurotrophic factor signaling modulates cocaine induction of reward-associated ultrasonic vocalization in rats.
Journal: The Journal of pharmacology and experimental therapeutics 20100201
Title: Glial cell line-derived neurotrophic factor acutely modulates the excitability of rat small-diameter trigeminal ganglion neurons innervating facial skin.
Journal: Brain, behavior, and immunity 20100101
Title: Transient signaling of Erk1/2, Akt and PLCgamma induced by nerve growth factor in brain capillary endothelial cells.
Journal: Vascular pharmacology 20100101
Title: The roles of BDNF, pCREB and Wnt3a in the latent period preceding activation of progenitor cell mitosis in the adult dentate gyrus by fluoxetine.
Journal: PloS one 20100101
Title: Neurotrophin signaling through tropomyosin receptor kinases contributes to survival and proliferation of non-Hodgkin lymphoma.
Journal: Experimental hematology 20091101
Title: Epidermal growth factor receptor inhibitors promote CNS axon growth through off-target effects on glia.
Journal: Neurobiology of disease 20091001
Title: Molecular cloning, sequence analysis and functional characterization of the gene cluster for biosynthesis of K-252a and its analogs.
Journal: Molecular bioSystems 20091001
Title: Biochemical characterization and substrate specificity of the gene cluster for biosyntheses of K-252a and its analogs by in vitro heterologous expression system of Escherichia coli.
Journal: Molecular bioSystems 20091001
Title: Nerve growth factor enhances cough and airway obstruction via TrkA receptor- and TRPV1-dependent mechanisms.
Journal: Thorax 20090901
Title: Fates of neurotrophins after retrograde axonal transport: phosphorylation of p75NTR is a sorting signal for delayed degradation.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090826
Title: BDNF-TrkB signaling pathway mediates the induction of epileptiform activity induced by a convulsant drug cyclothiazide.
Journal: Neuropharmacology 20090701
Title: Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain-derived neurotrophic factor and synaptotagmin I.
Journal: The Journal of physiology 20090701
Title: Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway.
Journal: Science signaling 20090428
Title: BDNF exerts contrasting effects on peripheral myelination of NGF-dependent and BDNF-dependent DRG neurons.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090401
Title: Crystal structures of MEK1 binary and ternary complexes with nucleotides and inhibitors.
Journal: Biochemistry 20090331
Title: Sciatic nerve conditioned medium depleted of pro-NGF modulates sodium currents and neurite outgrowth in PC12 cells.
Journal: Neuroscience 20090317
Title: Dehydroepiandrosterone and neurotrophins favor axonal growth in a sensory neuron-keratinocyte coculture model.
Journal: Neuroscience 20090317
Title: Production of chromopyrrolic acid by coexpression of inkOD in a heterologous host Streptomyces albus.
Journal: Bioorganic & medicinal chemistry letters 20090315
Title: Brain-derived neurotrophic factor inhibits spontaneous inhibitory postsynaptic currents in the rat supraoptic nucleus.
Journal: Brain research 20090303
Title: Different protection of K252a and N-acetyl-L-cysteine against amyloid-beta peptide-induced cortical neuron apoptosis involving inhibition of MLK3-MKK7-JNK3 signal cascades.
Journal: Journal of neuroscience research 20090301
Title: Complementary actions of BDNF and neurotrophin-3 on the firing patterns and synaptic composition of motoneurons.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090114
Title: Influence of brain-derived neurotrophic factor on pathfinding of dentate granule cell axons, the hippocampal mossy fibers.
Journal: Molecular brain 20090101
Title: [Role of tyrosine kinase of Trk-receptors in realization of antioxidant effect of ganglioside GM1 in PC12 cells].
Journal: Zhurnal evoliutsionnoi biokhimii i fiziologii 20090101
Title: Nerve growth factor acts with the beta2-adrenoceptor to induce spontaneous nociceptive behavior during temporomandibular joint inflammatory hyperalgesia.
Journal: Life sciences 20081205
Title: Presynaptic and postsynaptic NMDA receptors mediate distinct effects of brain-derived neurotrophic factor on synaptic transmission.
Journal: Journal of neurophysiology 20081201
Title: The motor complex of Plasmodium falciparum: phosphorylation by a calcium-dependent protein kinase.
Journal: The Journal of biological chemistry 20081107
Title: In vivo BDNF modulation of adult functional and morphological synaptic plasticity at hippocampal mossy fibers.
Journal: Neuroscience letters 20081107
Title: Initiation of testicular tubulogenesis is controlled by neurotrophic tyrosine receptor kinases in a three-dimensional Sertoli cell aggregation assay.
Journal: Reproduction (Cambridge, England) 20081001
Title: BDNF-TrkB signaling interacts with the GABAergic system to inhibit rhythmic swallowing in the rat.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20081001
Title: CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice.
Journal: Molecular and cellular neurosciences 20080901
Title: Schwann cell mediated trophic effects by differentiated mesenchymal stem cells.
Journal: Experimental cell research 20080815
Title: Neurotrophins and their receptors stimulate melanoma cell proliferation and migration.
Journal: The Journal of investigative dermatology 20080801
Title: Role of brain-derived neurotrophic factor in hyperoxia-induced enhancement of contractility and impairment of relaxation in lung parenchyma.
Journal: American journal of physiology. Lung cellular and molecular physiology 20080801
Title: BDNF induces late-phase LTP of C-fiber evoked field potentials in rat spinal dorsal horn.
Journal: Experimental neurology 20080801
Title: Upregulation of hippocampal TrkB and synaptotagmin is involved in treadmill exercise-enhanced aversive memory in mice.
Journal: Neurobiology of learning and memory 20080701
Title: Blockade of NGF and trk receptors inhibits increased peripheral mechanical sensitivity accompanying cystitis in rats.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20080701
Title: Brain-derived neurotrophic factor enhances the excitability of rat sensory neurons through activation of the p75 neurotrophin receptor and the sphingomyelin pathway.
Journal: The Journal of physiology 20080701
Title: Cytosolic accumulation of gammaH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells.
Journal: Experimental & molecular medicine 20080630
Title: Dopamine D1 receptor-induced signaling through TrkB receptors in striatal neurons.
Journal: The Journal of biological chemistry 20080606
Title: Brain-derived neurotrophic factor-mediated retrograde signaling required for the induction of long-term potentiation at inhibitory synapses of visual cortical pyramidal neurons.
Journal: Neuroscience research 20080601
Title: Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB.
Journal: Brain research 20080519
Title: Enhancement of long-term potentiation by brain-derived neurotrophic factor requires adenosine A2A receptor activation by endogenous adenosine.
Journal: Neuropharmacology 20080501
Title: Protein tyrosine kinase inhibitors modify kainic acid-induced epileptiform activity and mossy fiber sprouting but do not protect against limbic cell death.
Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20080501
Title: A causal role for brain-derived neurotrophic factor in the homeostatic regulation of sleep.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080409
Title: Inhibition of PHF-like tau hyperphosphorylation in SH-SY5Y cells and rat brain slices by K252a.
Journal: Journal of Alzheimer's disease : JAD 20080401
Title: Reduced potassium-chloride co-transporter expression in spinal cord dorsal horn neurons contributes to inflammatory pain hypersensitivity in rats.
Journal: Neuroscience 20080318
Title: K252a is highly effective in suppressing the growth of human endometrial cancer cells, but has little effect on normal human endometrial epithelial cells.
Journal: Oncology reports 20080301
Title: Ebselen, a redox regulator containing a selenium atom, induces neurofilament M expression in cultured rat pheochromocytoma PC12 cells via activation of mitogen-activated protein kinase.
Journal: Journal of neuroscience research 20080215
Title: Staurosporine-based binding assay for testing the affinity of compounds to protein kinases.
Journal: Analytical biochemistry 20080215
Title: Identification of the prosurvival activity of nerve growth factor on cardiac myocytes.
Journal: Cell death and differentiation 20080201
Title: [Blocking TrkB-BDNF signal pathway decreases the livability of neuroblastoma cells].
Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20080201
Title: Trk: a neuromodulator of age-specific behavioral and neurochemical responses to cocaine in mice.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080130
Title: Autocrine NGFbeta/TRKA signalling is an important survival factor for Hodgkin lymphoma derived cell lines.
Journal: Leukemia research 20080101
Title: Micro-electrode flux estimation confirms that the Solanum pimpinellifolium cu3 mutant still responds to systemin.
Journal: Plant physiology 20080101
Title: Granule formation in NGF-cultured mast cells is associated with expressions of pyruvate kinase type M2 and annexin I proteins.
Journal: International archives of allergy and immunology 20080101
Title: K252a prevents nigral dopaminergic cell death induced by 6-hydroxydopamine through inhibition of both mixed-lineage kinase 3/c-Jun NH2-terminal kinase 3 (JNK3) and apoptosis-inducing kinase 1/JNK3 signaling pathways.
Journal: Molecular pharmacology 20071201
Title: Polyploidization of 2nH1 (ES) cells by K-252a and staurosporine.
Journal: Human cell 20071101
Title: Use of a chemical genetic technique to identify myosin IIb as a substrate of the Abl-related gene (Arg) tyrosine kinase.
Journal: Biochemistry 20071016
Title: Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53.
Journal: Oncogene 20071011
Title: Neuroprotective effect of ganglioside GM1 on the cytotoxic action of hydrogen peroxide and amyloid beta-peptide in PC12 cells.
Journal: Neurochemical research 20070801
Title: Genetic organization of the biosynthetic gene cluster for the indolocarbazole K-252a in Nonomuraea longicatena JCM 11136.
Journal: Applied microbiology and biotechnology 20070701
Title: Nerve growth factor mediates steroid-resistant inflammation in respiratory syncytial virus infection.
Journal: Pediatric pulmonology 20070601
Title: Effects of NGF and BDNF on baseline glutamate and dopamine release in the hippocampal formation of the adult rat.
Journal: Brain research 20070413
Title: Nerve growth factor acutely potentiates synaptic transmission in vitro and induces dendritic growth in vivo on adult neurons in airway parasympathetic ganglia.
Journal: American journal of physiology. Lung cellular and molecular physiology 20070401
Title: Regulation of glycinergic and GABAergic synaptogenesis by brain-derived neurotrophic factor in developing spinal neurons.
Journal: Neuroscience 20070316
Title: Synthesis of N-protected staurosporinones.
Journal: The Journal of organic chemistry 20070316
Title: Nerve growth factor enhances voltage-gated Na+ channel activity and Transwell migration in Mat-LyLu rat prostate cancer cell line.
Journal: Journal of cellular physiology 20070301
Title: Ligusticum chuanxiong prevents rat pheochromocytoma cells from serum deprivation-induced apoptosis through a protein kinase A-dependent pathway.
Journal: Journal of ethnopharmacology 20070212
Title: Synthesis and mixed lineage kinase activity of pyrrolocarbazole and isoindolone analogs of (+)K-252a.
Journal: Journal of medicinal chemistry 20070208
Title: A nerve growth factor-induced retrograde survival signal mediated by mechanisms downstream of TrkA.
Journal: Neuropharmacology 20070201
Title: Effects of high-affinity nerve growth factor receptor inhibitors on symptoms in the NC/Nga mouse atopic dermatitis model.
Journal: The British journal of dermatology 20070201
Title: The Trk tyrosine kinase inhibitor K252a regulates growth of lung adenocarcinomas.
Journal: Molecular and cellular biochemistry 20070101
Title: The neuropeptide pituitary adenylate cyclase activating protein stimulates human monocytes by transactivation of the Trk/NGF pathway.
Journal: Cellular signalling 20070101
Title: beta-Nerve growth factor participates in an auto/paracrine pathway of regulation of the meiotic differentiation of rat spermatocytes.
Journal: Journal of cellular physiology 20070101
Title: PC12 cells regulate inducible cyclic AMP (cAMP) element repressor expression to differentially control cAMP response element-dependent transcription in response to nerve growth factor and cAMP.
Journal: Journal of neurochemistry 20061201
Title: Brain-derived neurotrophic factor regulation of N-methyl-D-aspartate receptor-mediated synaptic currents in suprachiasmatic nucleus neurons.
Journal: Journal of neuroscience research 20061115
Title: Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells.
Journal: Journal of cell science 20061115
Title: Shuttling of HDAC5 in H9C2 cells regulates YY1 function through CaMKIV/PKD and PP2A.
Journal: American journal of physiology. Cell physiology 20061101
Title: The cytokine/neurotrophin axis in peripheral axon outgrowth.
Journal: The European journal of neuroscience 20061101
Title: Airway hyper-responsiveness in allergic asthma in guinea-pigs is mediated by nerve growth factor via the induction of substance P: a potential role for trkA.
Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060901
Title: BDNF enhances dendritic Ca2+ signals evoked by coincident EPSPs and back-propagating action potentials in CA1 pyramidal neurons.
Journal: Brain research 20060809
Title: Brain-derived neurotrophic factor and neurotrophin receptors modulate glutamate-induced phase shifts of the suprachiasmatic nucleus.
Journal: The European journal of neuroscience 20060801
Title: Nicotine regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor.
Journal: Brain research 20060726
Title: Increase of Fas-induced apoptosis by inhibition of extracellular phosphorylation of Fas receptor in Jurkat cell line.
Journal: Apoptosis : an international journal on programmed cell death 20060701
Title: Phosphoryl transfer is not rate-limiting for the ROCK I-catalyzed kinase reaction.
Journal: Biochemistry 20060627
Title: Targeting the c-Met signaling pathway in cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060615
Title: Spike timing-dependent LTP/LTD mediates visual experience-dependent plasticity in a developing retinotectal system.
Journal: Neuron 20060406
Title: K252a, an inhibitor of Trk, disturbs pathfinding of hippocampal mossy fibers.
Journal: Neuroreport 20060403
Title: Brain-derived neurotrophic factor silences GABA synapses onto hypothalamic neuroendocrine cells through a postsynaptic dynamin-mediated mechanism.
Journal: Journal of neurophysiology 20060401
Title: Nerve growth factor regulates substance P in adult sensory neurons through both TrkA and p75 receptors.
Journal: Experimental neurology 20060201
Title: Distinct effects of p75 in mediating actions of neurotrophins on basal forebrain oligodendrocytes.
Journal: Molecular and cellular neurosciences 20060201
Title: Cyclic-AMP response element-based signaling assays for characterization of Trk family tyrosine kinases modulators.
Journal: Neuro-Signals 20060101
Title: Molecular pathways leading to oxidative stress-induced phosphorylation of Akt.
Journal: Antioxidants & redox signaling 20060101
Title: Nerve growth factor-induced migration of endothelial cells.
Journal: The Journal of pharmacology and experimental therapeutics 20051201
Title: Biosynthesis of indocarbazostatin B, incorporation of D-[U-13C] glucose and L-[2-13C] tryptophan.
Journal: The Journal of antibiotics 20051201
Title: Transcription factor specificity protein 1 (Sp1) is the main regulator of nerve growth factor-induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12.
Journal: Journal of neurochemistry 20051101
Title: Regulation of the wild-type and Y1235D mutant Met kinase activation.
Journal: Biochemistry 20051101
Title: Agents targeting c-Jun N-terminal kinase pathway as potential neuroprotectants.
Journal: Expert opinion on investigational drugs 20051101
Title: Nitric oxide donors induce neurotrophin-like survival signaling and protect neurons against apoptosis.
Journal: Molecular pharmacology 20051001
Title: Rapid modulation of inhibitory synaptic currents in cerebellar Purkinje cells by BDNF.
Journal: Synapse (New York, N.Y.) 20050915
Title: Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production.
Journal: European journal of pharmacology 20050905
Title: Low concentrations of aggregated beta-amyloid induce neurite formation via the neurotrophin receptor p75.
Journal: Journal of molecular medicine (Berlin, Germany) 20050901
Title: The synthesis of bioactive indolocarbazoles related to K-252a.
Journal: Organic & biomolecular chemistry 20050821
Title: Dissection of bidirectional synaptic plasticity into saturable unidirectional processes.
Journal: Journal of neurophysiology 20050801
Title: Protein phosphorylation is a prerequisite for intracellular Ca2+ release and ion channel control by nitric oxide and abscisic acid in guard cells.
Journal: The Plant journal : for cell and molecular biology 20050801
Title: Characterization of cAMP-dependent proteolysis of GATA-6.
Journal: Biochemical and biophysical research communications 20050715
Title: Is myosin light-chain phosphorylation a regulatory signal for the osmotic activation of the Na+-K+-2Cl- cotransporter?
Journal: American journal of physiology. Cell physiology 20050701
Title: K252a inhibits proliferation of ovarian cancer cells by upregulating p21WAF1.
Journal: Oncology reports 20050701
Title: Synthesis, modeling, and in vitro activity of (3'S)-epi-K-252a analogues. Elucidating the stereochemical requirements of the 3'-sugar alcohol on trkA tyrosine kinase activity.
Journal: Journal of medicinal chemistry 20050602
Title: Increasing the kinase specificity of k252a by protein surface recognition.
Journal: Organic letters 20050428
Title: Nerve growth factor rapidly increases muscarinic tone in mouse medial septum/diagonal band of Broca.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050427
Title: Effects of Schwann cell secreted factors on PC12 cell neuritogenesis and survival.
Journal: Journal of neurobiology 20050401
Title: N-methyl-D-aspartate and TrkB receptors protect neurons against glutamate excitotoxicity through an extracellular signal-regulated kinase pathway.
Journal: Journal of neuroscience research 20050401
Title: Induction method of tyrosine kinase A-mediated cell death in rat pheochromocytoma.
Journal: Biotechnology letters 20050401
Title: Laminin-1 is phosphorylated by ecto-protein kinases of monocytes.
Journal: The international journal of biochemistry & cell biology 20050201
Title: Enhancement of Schwann cell myelin formation by K252a in the Trembler-J mouse dorsal root ganglion explant culture.
Journal: Journal of neuroscience research 20050201
Title: Patterns of dentate granule cell responses to perforant path stimulation in epileptic mice with granule cell dispersion.
Journal: Epilepsy research 20050201
Title: The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region.
Journal: Neuroscience 20050101
Title: BDNF acutely modulates synaptic transmission and calcium signalling in developing cortical neurons.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20050101
Title: The role of tropomyosin-related kinase receptors in neurotrophin-induced rapid eye movement sleep in the cat.
Journal: Neuroscience 20050101
Title: Effect of p75 neurotrophin receptor antagonist on disease progression in transgenic amyotrophic lateral sclerosis mice.
Journal: Journal of neuroscience research 20041015
Title: Autocrine regulation of nerve growth factor expression by Trk receptors.
Journal: Journal of neurochemistry 20040901
Title: Brain-derived neurotrophic factor facilitates glutamate and inhibits GABA release from hippocampal synaptosomes through different mechanisms.
Journal: Brain research 20040730
Title: Nerve growth factor and substance P regulation in nasal sensory neurons after toluene diisocyanate exposure.
Journal: American journal of respiratory cell and molecular biology 20040601
Title: Brain-derived neurotrophic factor and tyrosine kinase receptor B involvement in amygdala-dependent fear conditioning.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040519
Title: Brain-derived neurotrophic factor-elicited or sciatic ligation-associated phosphorylation of cyclic AMP response element binding protein in the rat spinal dorsal horn is reduced by block of tyrosine kinase receptors.
Journal: Neuroscience letters 20040506
Title: Exercise induces BDNF and synapsin I to specific hippocampal subfields.
Journal: Journal of neuroscience research 20040501
Title: Effect of exogenous neurotrophins on Trk receptor phosphorylation, cell proliferation, and neurotrophin secretion by cells isolated from the human lamina cribrosa.
Journal: Molecular vision 20040419
Title: Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic transmission in hippocampal slices.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040324
Title: Oligogalacturonide signal transduction, induction of defense-related responses and protection of grapevine against Botrytis cinerea.
Journal: Planta 20040301
Title: Effect of K-252a and abscisic acid on the efflux of citrate from soybean roots.
Journal: Journal of experimental botany 20040301
Title: Phosphorylation and 14-3-3 binding of Arabidopsis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
Journal: The Plant journal : for cell and molecular biology 20040301
Title: Neurotrophins improve neuromuscular transmission in the adult rat diaphragm.
Journal: Muscle & nerve 20040301
Title: K252a, a high-affinity nerve growth factor receptor blocker, improves psoriasis: an in vivo study using the severe combined immunodeficient mouse-human skin model.
Journal: The Journal of investigative dermatology 20040301
Title: NGF activation of TrkA decreases N-myc expression via MAPK path leading to a decrease in neuroblastoma cell number.
Journal: Oncogene 20040226
Title: Mixed-lineage kinases: a target for the prevention of neurodegeneration.
Journal: Annual review of pharmacology and toxicology 20040101
Title: Brain-derived neurotrophic factor increases inhibitory synapses, revealed in solitary neurons cultured from rat visual cortex.
Journal: Neuroscience 20040101
Title: Activation of extracellular signal-regulated protein kinase in the dorsal root ganglion following inflammation near the nerve cell body.
Journal: Neuroscience 20040101
Title: Hippocampal excitability increases during the estrous cycle in the rat: a potential role for brain-derived neurotrophic factor.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20031217
Title: Spatial requirements for TrkA kinase activity in the support of neuronal survival and axon growth in rat sympathetic neurons.
Journal: Neuropharmacology 20031201
Title: The role of neurotrophin receptors in female germ-cell survival in mouse and human.
Journal: Development (Cambridge, England) 20031101
Title: Progesterone induces the proliferation of urothelial cells in an epidermal growth factor dependent manner.
Journal: The Journal of urology 20031101
Title: NGF activates the phosphorylation of MAP1B by GSK3beta through the TrkA receptor and not the p75(NTR) receptor.
Journal: Journal of neurochemistry 20031101
Title: Sustained intracellular Ca2+ elevation induced by a brief BDNF application in rat visual cortex neurons.
Journal: Neuroreport 20030806
Title: Staurosporine-inhibitable protein kinase activity associated with secretory granule membranes isolated from rat submandibular gland cells.
Journal: Archives of oral biology 20030801
Title: Acute pancreatitis results in referred mechanical hypersensitivity and neuropeptide up-regulation that can be suppressed by the protein kinase inhibitor k252a.
Journal: The journal of pain : official journal of the American Pain Society 20030801
Title: The trophic role of oligodendrocytes in the basal forebrain.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030702
Title: Possible involvement of energy metabolism in the change of cytoplasm organization induced by a protein phosphatase inhibitor, calyculin A, in root hair cells of Limnobium stoloniferum.
Journal: Protoplasma 20030601
Title: The action of BDNF on GABA(A) currents changes from potentiating to suppressing during maturation of rat hippocampal CA1 pyramidal neurons.
Journal: The Journal of physiology 20030501
Title: A fluorescence polarization assay for native protein substrates of kinases.
Journal: Analytical biochemistry 20030501
Title: Regulation of cell survival in the developing thalamus: an in vitro analysis.
Journal: Experimental neurology 20030501
Title: Signalling pathways involved in the short-term potentiation of dopamine release by BDNF.
Journal: Brain research 20030404
Title: Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030401
Title: Insulin or bFGF and C2 ceramide increase newborn rat retinal ganglion cell survival rate.
Journal: Biochemical and biophysical research communications 20030207
Title: Integrins regulate neuronal neurotrophin gene expression through effects on voltage-sensitive calcium channels.
Journal: Neuroscience 20030101
Title: K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK.
Journal: The Journal of biological chemistry 20021220
Title: Gangliosides activate Trk receptors by inducing the release of neurotrophins.
Journal: The Journal of biological chemistry 20021220
Title: Establishment of a triploid V79 cell line from tetraploid cells obtained through polyploidization using K-252a.
Journal: Cell proliferation 20021201
Title: Synthesis and kinase inhibitory activity of 3'-(S)-epi-K-252a.
Journal: Bioorganic & medicinal chemistry letters 20021021
Title: TrkA as a life and death receptor: receptor dose as a mediator of function.
Journal: Cancer research 20020901
Title: Characterization of early, chitin-induced gene expression in Arabidopsis.
Journal: Molecular plant-microbe interactions : MPMI 20020901
Title: Functional analysis of water channels in barley roots.
Journal: Plant & cell physiology 20020801
Title: K252a inhibits the oncogenic properties of Met, the HGF receptor.
Journal: Oncogene 20020725
Title: Modulation by PKA of the hyperpolarization-activated current (Ih) in cultured rat olfactory receptor neurons.
Journal: The Journal of membrane biology 20020715
Title: Control of cortical interneuron migration by neurotrophins and PI3-kinase signaling.
Journal: Development (Cambridge, England) 20020701
Title: Modulation of neurotransmitter release induced by brain-derived neurotrophic factor in rat brain striatal slices in vitro.
Journal: Brain research 20020621
Title: Estrogen-induced proliferation of urothelial cells is modulated by nerve growth factor.
Journal: American journal of physiology. Renal physiology 20020601
Title: Signal transduction controlling the blue- and red-light mediated gene expression of S-adenosylmethionine decarboxylase in Pharbitis nil.
Journal: Journal of experimental botany 20020601
Title: Detection of NGF-receptors TrkA and p75NTR in human tumor cell lines and effect of NGF on the growth characteristic of the UT-7/EPO cell line.
Journal: Journal of experimental & clinical cancer research : CR 20020601
Title: Phosphorylation of the salivary Na(+)-K(+)-2Cl(-) cotransporter.
Journal: American journal of physiology. Cell physiology 20020401
Title: Activation of the promoters of Arabidopsis genes for the branched-chain alpha-keto acid dehydrogenase complex in transgenic tobacco BY-2 cells under sugar starvation.
Journal: Plant & cell physiology 20020301
Title: A synaptic potentiation by a protein factor distinct from those induced by neurotrophins.
Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20020201
Title: NGF rescues human B lymphocytes from anti-IgM induced apoptosis by activation of PKCzeta.
Journal: European journal of immunology 20020101
Title: Cooperativity between extracellular adenosine 5'-triphosphate and activation of N-methyl-D-aspartate receptors in long-term potentiation induction in hippocampal CA1 neurons.
Journal: Neuroscience 20020101
Title: The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants.
Journal: Cancer journal (Sudbury, Mass.) 20020101
Title: Co-activation of the phosphatidylinositol-3-kinase/Akt signaling pathway by N-methyl-D-aspartate and TrkB receptors in cerebellar granule cell neurons.
Journal: Amino acids 20020101
Title: Lymnaea epidermal growth factor promotes axonal regeneration in CNS organ culture.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20011201
Title: Transforming growth factor-beta1 enhances expression of brain-derived neurotrophic factor and its receptor, TrkB, in neurons cultured from rat cerebral cortex.
Journal: Journal of neuroscience research 20011101
Title: Phosphorylation-dependent modulation of cardiac calcium current by intracellular free magnesium.
Journal: American journal of physiology. Heart and circulatory physiology 20011001
Title: Brain-derived neurotrophic factor induces long-lasting potentiation of synaptic transmission in visual cortex in vivo in young rats, but not in the adult.
Journal: The European journal of neuroscience 20011001
Title: BDNF induces glutamate release in cerebrocortical nerve terminals and in cortical astrocytes.
Journal: Neuroreport 20010828
Title: K252a, an indrocarbazole derivative, causes the membrane of myoblasts to enter a fusion-capable state.
Journal: Biochemical and biophysical research communications 20010803
Title: Establishment of a tetraploid Meth-A cell line through polyploidization by demecolcine but not by staurosporine, K-252A and paclitaxel.
Journal: Cell proliferation 20010801
Title: Rapid stimulatory effects of brain-derived neurotrophic factor and neurotrophin-3 on somatostatin release and intracellular calcium rise in primary hypothalamic cell cultures.
Journal: Neuroendocrinology 20010701
Title: Efficient syntheses of novel C2'-alkylated (+/-)-K252a analogues.
Journal: Organic letters 20010531
Title: Calcium/calmodulin-dependent protein kinase inhibition potentiates thapsigargin-mediated cell death in SH-SY5Y human neuroblastoma cells.
Journal: Neuroscience letters 20010330
Title: Venom from the platypus, Ornithorhynchus anatinus, induces a calcium-dependent current in cultured dorsal root ganglion cells.
Journal: Journal of neurophysiology 20010301
Title: Truncated trkB.T1 is dominant negative inhibitor of trkB.TK+-mediated cell survival.
Journal: Biochemical and biophysical research communications 20010209
Title: Signal transduction pathways through TRK-A and TRK-B receptors in human neuroblastoma cells.
Journal: Japanese journal of cancer research : Gann 20010201
Title: Neurotrophin-3 mediates the autocrine survival of the catecholaminergic CAD CNS neuronal cell line.
Journal: Journal of neurochemistry 20010101
Title: Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons.
Journal: Pain 20010101
Title: Ligand modulation of glial activation: cell permeable, small molecule inhibitors of serine-threonine protein kinases can block induction of interleukin 1 beta and nitric oxide synthase II.
Journal: Neurochemistry international 20010101
Title: Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase.
Journal: Antiviral research 20001001
Title: Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site.
Journal: Molecular pharmacology 20000701
Title: Potent and preferential inhibition of Ca2+/calmodulin-dependent protein kinase II by K252a and its derivative, KT5926.
Journal: Biochemical and biophysical research communications 19911127
Title: The regulation of Na/K/2Cl cotransport and bumetanide binding in avian erythrocytes by protein phosphorylation and dephosphorylation. Effects of kinase inhibitors and okadaic acid.
Journal: The Journal of biological chemistry 19901205
Title: Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases.
Journal: Trends in pharmacological sciences 19890601
