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Title: Synthesis and structure-activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents.
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Title: Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaks.
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Title: Discovery and optimization of a series of 2-aryl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazoles as novel anticancer agents.
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Title: Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity.
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Title: Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents.
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Title: Pharmacokinetics, excretion, and distribution of combretastatin A4 phosphate in rats.
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Title: Design, synthesis and biological evaluation of novel chalcone derivatives as antitubulin agents.
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Title: Synthesis, biological evaluation, and molecular docking studies of 2,6-dinitro-4-(trifluoromethyl)phenoxysalicylaldoxime derivatives as novel antitubulin agents.
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Title: Cholesterol superlattice modulates CA4P release from liposomes and CA4P cytotoxicity on mammary cancer cells.
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Title: Diffusion-weighted MR imaging allows monitoring the effect of combretastatin A4 phosphate on rabbit implanted VX2 tumor model: 12-day dynamic results.
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Title: Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1.
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Title: Synthesis and structure-activity relationship study of antimicrotubule agents phenylahistin derivatives with a didehydropiperazine-2,5-dione structure.
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Title: Synthesis and evaluation of 1,5-disubstituted tetrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative and antitumor activity.
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Title: Targeted delivery of a combination therapy consisting of combretastatin A4 and low-dose doxorubicin against tumor neovasculature.
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Title: Phase Ib trial of radiotherapy in combination with combretastatin-A4-phosphate in patients with non-small-cell lung cancer, prostate adenocarcinoma, and squamous cell carcinoma of the head and neck.
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Title: Comparison of two vascular-disrupting agents at a clinically relevant dose in rodent liver tumors with multiparametric magnetic resonance imaging biomarkers.
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Title: c-Jun N-terminal kinase mediates microtubule-depolymerizing agent-induced microtubule depolymerization and G2/M arrest in MCF-7 breast cancer cells.
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Title: Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1.
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Title: Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.
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Title: 5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2.
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Title: Patterning cells and shear flow conditions: convenient observation of endothelial cell remoulding, enhanced production of angiogenesis factors and drug response.
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Title: Endostar enhances the antineoplastic effects of combretastatin A4 phosphate in an osteosarcoma xenograft.
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Title: One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazole: a unique, highly active antimicrotubule agent.
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Title: Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships.
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Title: 1,1-Diarylalkenes as anticancer agents: dual inhibitors of tubulin polymerization and phosphodiesterase 4.
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Title: Vascular effects dominate solid tumor response to treatment with combretastatin A-4-phosphate.
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Title: The metabolic fate of isocombretastatin A-4 in human liver microsomes: identification, synthesis and biological evaluation of metabolites.
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Title: Design, synthesis, and cytotoxicity of novel 3-arylidenones derived from alicyclic ketones.
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Title: Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.
Journal: Journal of medicinal chemistry 20110908
Title: Synthesis and biological activities of (R)- and (S)-N-(4-Methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride as potent cytotoxic antitubulin agents.
Journal: Journal of medicinal chemistry 20110908
Title: Synthesis and structure-activity relationships of constrained heterocyclic analogues of combretastatin A4.
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Title: Microflow of fluorescently labelled red blood cells in tumours expressing single isoforms of VEGF and their response to vascular targeting agents.
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Title: Phase II trial of combretastatin A4 phosphate, carboplatin, and paclitaxel in patients with platinum-resistant ovarian cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20110901
Title: Design, synthesis and antiproliferative activities of biarylolefins based on polyhydroxylated and carbohydrate scaffolds.
Journal: European journal of medicinal chemistry 20110901
Title: Synthesis and biological evaluation of 1-(4'-Indolyl and 6'-Quinolinyl) indoles as a new class of potent anticancer agents.
Journal: European journal of medicinal chemistry 20110901
Title: Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe.
Journal: European journal of medicinal chemistry 20110901
Title: Investigation of protein induction in tumour vascular targeted strategies by MALDI MSI.
Journal: Methods (San Diego, Calif.) 20110801
Title: Synthesis and biological evaluation of 4β-acrylamidopodophyllotoxin congeners as DNA damaging agents.
Journal: Bioorganic & medicinal chemistry 20110801
Title: Convergent synthesis and biological evaluation of 2-amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as microtubule targeting agents.
Journal: Journal of medicinal chemistry 20110728
Title: Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues.
Journal: Journal of medicinal chemistry 20110728
Title: Regioselective synthesis of water-soluble monophosphate derivatives of combretastatin A-1.
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Title: Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4.
Journal: Journal of medicinal chemistry 20110714
Title: A novel class of trans-methylpyrazoline analogs of combretastatins: synthesis and in-vitro biological testing.
Journal: European journal of medicinal chemistry 20110701
Title: A pharmacokinetic and safety study of single dose intravenous combretastatin A4 phosphate in Chinese patients with refractory solid tumours.
Journal: British journal of clinical pharmacology 20110601
Title: In vivo near-infrared spectroscopy and magnetic resonance imaging monitoring of tumor response to combretastatin A-4-phosphate correlated with therapeutic outcome.
Journal: International journal of radiation oncology, biology, physics 20110601
Title: Imidazolone-amide bridges and their effects on tubulin polymerization in cis-locked vinylogous combretastatin-A4 analogues: synthesis and biological evaluation.
Journal: Bioorganic & medicinal chemistry 20110601
Title: Synthesis and biological evaluation of 4-arylcoumarin analogues of combretastatins. Part 2.
Journal: Journal of medicinal chemistry 20110512
Title: TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice.
Journal: The Journal of clinical investigation 20110502
Title: Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivatives.
Journal: Bioorganic & medicinal chemistry letters 20110501
Title: 4,5-Diaryl-3-aminopyrazole derivatives as analogs of Combretastatin A-4: synthesis and biological evaluation.
Journal: Archiv der Pharmazie 20110501
Title: BubR1 is required for the mitotic block induced by combretastatin-A4 and a novel cis-restricted ß-lactam analogue in human cancer cells.
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Title: Synthesis, biological evaluation, and molecular docking studies of resveratrol derivatives possessing chalcone moiety as potential antitubulin agents.
Journal: Bioorganic & medicinal chemistry 20110415
Title: Design, synthesis, and biological evaluation of novel γ-carboline ketones as anticancer agents.
Journal: European journal of medicinal chemistry 20110401
Title: Design and synthesis of novel enhanced water soluble hydroxyethyl analogs of combretastatin A-4.
Journal: Bioorganic & medicinal chemistry letters 20110401
Title: Acetyl analogs of combretastatin A-4: synthesis and biological studies.
Journal: Bioorganic & medicinal chemistry 20110401
Title: Synthesis and cytotoxic evaluation of N-(4-methoxy-1H-benzo[d]imidazol-7-yl)-arylsulfonamide and N-aryl-(4-methoxy-1H-benzo[d]imidazol)-7-sulfonamide analogs of combretastatin A-4.
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Title: Application of plant allylpolyalkoxybenzenes in synthesis of antimitotic phenstatin analogues.
Journal: Bioorganic & medicinal chemistry letters 20110315
Title: Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents.
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Title: Enhanced anti-tumor activity by the combination of TRAIL/Apo-2L and combretastatin A-4 against human colon cancer cells via induction of apoptosis in vitro and in vivo.
Journal: Cancer letters 20110301
Title: Materializing sequential killing of tumor vasculature and tumor cells via targeted polymeric micelle system.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20110210
Title: Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents.
Journal: European journal of medicinal chemistry 20110201
Title: Support of a free radical mechanism for enhanced antitumor efficacy of the microtubule disruptor OXi4503.
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Title: Combretastatin-induced hypertension and the consequences for its combination with other therapies.
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Title: Domino approach to 2-aroyltrimethoxyindoles as novel heterocyclic combretastatin A4 analogues.
Journal: European journal of medicinal chemistry 20110101
Title: Developments of combretastatin A-4 derivatives as anticancer agents.
Journal: Current medicinal chemistry 20110101
Title: Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk.
Journal: Bioorganic & medicinal chemistry 20110101
Title: Stable combretastatin A-4 analogues with sub-nanomolar efficacy against chemoresistant HT-29 cells.
Journal: International journal of clinical pharmacology and therapeutics 20110101
Title: Computational modeling of tumor response to vascular-targeting therapies--part I: validation.
Journal: Computational and mathematical methods in medicine 20110101
Title: Biological potential and structure-activity relationships of most recently developed vascular disrupting agents: an overview of new derivatives of natural combretastatin a-4.
Journal: Current medicinal chemistry 20110101
Title: Combretastatin A4 phosphate induces programmed cell death in vascular endothelial cells.
Journal: Oncology research 20110101
Title: Multifunctional dendrimer/combretastatin A4 inclusion complexes enable in vitro targeted cancer therapy.
Journal: International journal of nanomedicine 20110101
Title: Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents.
Journal: Journal of medicinal chemistry 20101223
Title: Lead identification of conformationally restricted β-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects.
Journal: European journal of medicinal chemistry 20101201
Title: Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-aryl/arylaminobenzo[b]thiophene derivatives as a novel class of antiproliferative agents.
Journal: European journal of medicinal chemistry 20101201
Title: Synthesis, molecular modeling and biological evaluation of guanidine derivatives as novel antitubulin agents.
Journal: Bioorganic & medicinal chemistry 20101201
Title: Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy.
Journal: Molecular cancer therapeutics 20101201
Title: Synthesis of antimitotic polyalkoxyphenyl derivatives of combretastatin using plant allylpolyalkoxybenzenes.
Journal: Journal of natural products 20101129
Title: Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance.
Journal: Journal of medicinal chemistry 20101125
Title: Self-assembled core-shell vascular-targeted nanocapsules for temporal antivasculature and anticancer activities.
Journal: Small (Weinheim an der Bergstrasse, Germany) 20101122
Title: Effects of a combretastatin A4 analogous chalcone and its Pt-complex on cancer cells: A comparative study of uptake, cell cycle and damage to cellular compartments.
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Title: The vascular targeting agent combretastatin-A4 and a novel cis-Restricted {beta}-Lactam Analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo patient samples including those displaying multidrug resistance.
Journal: The Journal of pharmacology and experimental therapeutics 20101101
Title: Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents.
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Title: Non-invasive imaging of combretastatin activity in two tumor models: Association with invasive estimates.
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Title: 4-(3-Halo/amino-4,5-dimethoxyphenyl)-5-aryloxazoles and -N-methylimidazoles that are cytotoxic against combretastatin A resistant tumor cells and vascular disrupting in a cisplatin resistant germ cell tumor model.
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Title: 1,2,3-triazole analogs of combretastatin A-4 as potential microtubule-binding agents.
Journal: Bioorganic & medicinal chemistry 20100915
Title: Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors.
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Title: Structure-activity relationships of indole compounds derived from combretastatin A4: synthesis and biological screening of 5-phenylpyrrolo[3,4-a]carbazole-1,3-diones as potential antivascular agents.
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Title: Design, synthesis and biological evaluation of 3,5-diaryl-isoxazoline/isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents.
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Title: Targeted polymeric micelle system for delivery of combretastatin A4 to tumor vasculature in vitro.
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Title: A nanocapsular combinatorial sequential drug delivery system for antiangiogenesis and anticancer activities.
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Title: Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: an easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4.
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Title: Synthesis and anti-cancer activity of chalcone linked imidazolones.
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Title: Evaluation of 5-hydroxy-2,3-diaryl (substituted)-cyclopent-2-en-1-ones as cis-restricted analogues of combretastatin A-4 as novel anti angiogenic and anticancer agents.
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Title: Novel combretastatin A-4 derivative XN0502 induces cell cycle arrest and apoptosis in A549 cells.
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Title: Combretastatin A-4 inhibits cell growth and metastasis in bladder cancer cells and retards tumour growth in a murine orthotopic bladder tumour model.
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Title: Combretastatin A4 phosphate: a novel vascular disrupting agent.
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Title: Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents.
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Title: Substituted 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors.
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Title: Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4.
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Title: Structural determinants of resveratrol for cell proliferation inhibition potency: experimental and docking studies of new analogs.
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Title: Regio- and stereospecific synthesis of mono-beta-d-glucuronic acid derivatives of combretastatin A-1.
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Title: Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity.
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Title: Reproducibility and changes in the apparent diffusion coefficients of solid tumours treated with combretastatin A4 phosphate and bevacizumab in a two-centre phase I clinical trial.
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Title: AVE8062: a new combretastatin derivative vascular disrupting agent.
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Title: Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a resveratrol structural modification.
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Title: Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one analogues as potent antitumor agents that inhibit tubulin assembly.
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Title: 1,4-Diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126) enhances the cytotoxicity of combretastatin A4 independently of mitogen-activated protein kinase kinase.
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Title: Anticancer strategies involving the vasculature.
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Title: A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4.
Journal: European journal of medicinal chemistry 20090601
Title: Targeted treatment of choroidal neovascularization using integrin-mediated sterically stabilized liposomes loaded with combretastatin A4.
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Title: Nitric oxide synthase inhibition enhances the tumor vascular-damaging effects of combretastatin a-4 3-o-phosphate at clinically relevant doses.
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Title: Vascular disrupting agents: a novel mechanism of action in the battle against non-small cell lung cancer.
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Title: Synthesis and biological evaluation of cis-locked vinylogous combretastatin-A4 analogues: derivatives with a cyclopropyl-vinyl or a cyclopropyl-amide bridge.
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Title: Diffusion-weighted MRI of hepatic tumor in rats: comparison between in vivo and postmortem imaging acquisitions.
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Title: A phase II trial of fosbretabulin in advanced anaplastic thyroid carcinoma and correlation of baseline serum-soluble intracellular adhesion molecule-1 with outcome.
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Title: Up-regulation of connective tissue growth factor in endothelial cells by the microtubule-destabilizing agent combretastatin A-4.
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Journal: Expert opinion on investigational drugs 20090201
Title: In vitro and in vivo phase II metabolism of combretastatin A-4: evidence for the formation of a sulphate conjugate metabolite.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20090201
Title: Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
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Title: Design, synthesis and biological evaluation of novel stilbene-based antitumor agents.
Journal: Bioorganic & medicinal chemistry 20090115
Title: Treatment of rodent liver tumor with combretastatin a4 phosphate: noninvasive therapeutic evaluation using multiparametric magnetic resonance imaging in correlation with microangiography and histology.
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Title: Combination of combretastatin A4 phosphate and doxorubicin-containing liposomes affects growth of B16-F10 tumors.
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Title: Pharmacological inhibition of the hypertensive response to combretastatin A-4 phosphate in rats.
Journal: Vascular pharmacology 20090101
Title: Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents.
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Title: Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity.
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Title: Vibrational spectra and ab initio molecular orbital calculations of the novel anti-cancer drug combretastatin A-4 prodrug.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20081001
Title: Naphthylphenstatins as tubulin ligands: synthesis and biological evaluation.
Journal: Bioorganic & medicinal chemistry 20081001
Title: Synthesis and biological evaluation of polymethoxylated 4-heteroarylcoumarins as tubulin assembly inhibitor.
Journal: Bioorganic & medicinal chemistry 20081001
Title: Tumour vascular disrupting agents: combating treatment resistance.
Journal: The British journal of radiology 20081001
Title: Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4.
Journal: Bioorganic & medicinal chemistry letters 20080915
Title: Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization.
Journal: Bioorganic & medicinal chemistry 20080915
Title: 1,2,3,4-tetrahydro-2-thioxopyrimidine analogs of combretastatin-A4.
Journal: European journal of medicinal chemistry 20080901
Title: Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy.
Journal: Bioorganic & medicinal chemistry 20080901
Title: Antineoplastic agents. 552. Oxidation of combretastatin A-1: trapping the o-quinone intermediate considered the metabolic product of the corresponding phosphate prodrug.
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Title: Asymmetric synthesis of 2,3-dihydro-2-arylquinazolin-4-ones: methodology and application to a potent fluorescent tubulin inhibitor with anticancer activity.
Journal: Journal of medicinal chemistry 20080814
Title: Synthesis and biological evaluation of new disubstituted analogues of 6-methoxy-3-(3',4',5'-trimethoxybenzoyl)-1H-indole (BPR0L075), as potential antivascular agents.
Journal: Bioorganic & medicinal chemistry 20080801
Title: Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors.
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Title: Relationship between human tumour angiogenic profile and combretastatin-induced vascular shutdown: an exploratory study.
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Title: Antivascular effects of combretastatin A4 phosphate in breast cancer xenograft assessed using dynamic bioluminescence imaging and confirmed by MRI.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080701
Title: Synthesis and antitumor activity of benzils related to combretastatin A-4.
Journal: Bioorganic & medicinal chemistry letters 20080601
Title: Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization.
Journal: Bioorganic & medicinal chemistry 20080601
Title: Design, synthesis, and biological evaluation of thiophene analogues of chalcones.
Journal: Bioorganic & medicinal chemistry 20080515
Title: 2-(6-aryl-3(Z)-hexen-1,5-diynyl)anilines as a new class of potent antitubulin agents.
Journal: Journal of medicinal chemistry 20080508
Title: Synthesis and biological activity of fluorinated combretastatin analogues.
Journal: Journal of medicinal chemistry 20080508
Title: The tubulin-depolymerising agent combretastatin-4 induces ectopic aster assembly and mitotic catastrophe in lung cancer cells H460.
Journal: Apoptosis : an international journal on programmed cell death 20080501
Title: 1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin.
Journal: Bioorganic & medicinal chemistry 20080501
Title: Tubulysin analogs incorporating desmethyl and dimethyl tubuphenylalanine derivatives.
Journal: Bioorganic & medicinal chemistry letters 20080501
Title: p38 MAPK, but not ERK1/2, is critically involved in the cytotoxicity of the novel vascular disrupting agent combretastatin A4.
Journal: International journal of cancer 20080415
Title: Blood vessel maturation and response to vascular-disrupting therapy in single vascular endothelial growth factor-A isoform-producing tumors.
Journal: Cancer research 20080401
Title: Combretastatin A-4 activates AMP-activated protein kinase and improves glucose metabolism in db/db mice.
Journal: Pharmacological research 20080401
Title: Synthesis and biological evaluation of 1-methyl-2-(3',4',5'-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors.
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Title: Preclinical studies to predict efficacy of vascular changes induced by combretastatin a-4 disodium phosphate in patients.
Journal: International journal of radiation oncology, biology, physics 20080301
Title: Efficacy of selected natural products as therapeutic agents against cancer.
Journal: Journal of natural products 20080301
Title: Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents.
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Title: The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death.
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Title: Design, synthesis, and in vitro antitumor activity of new 1,4-diarylimidazole-2-ones and their 2-thione analogues.
Journal: Bioorganic & medicinal chemistry letters 20080201
Title: Segmentation of dynamic contrast enhanced magnetic resonance imaging data.
Journal: Acta oncologica (Stockholm, Sweden) 20080101
Title: Solution-phase parallel synthesis and biological evaluation of combretatriazoles.
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Title: The effect of combretastatin A4 disodium phosphate and 5,6-dimethylxanthenone-4-acetic acid on water diffusion and blood perfusion in tumours.
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Title: 3-(2'-Bromopropionylamino)-benzamides as novel S-phase arrest agents.
Journal: Bioorganic & medicinal chemistry letters 20071215
Title: In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20071201
Title: Mechanism of retinoblastoma tumor cell death after focal chemotherapy, radiation, and vascular targeting therapy in a mouse model.
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Title: Combretastatin a-4 analogs as anticancer agents.
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Title: Conformationally restricted macrocyclic analogues of combretastatins.
Journal: Bioorganic & medicinal chemistry letters 20071115
Title: Assessment of tumor response to the vascular disrupting agents 5,6-dimethylxanthenone-4-acetic acid or combretastatin-A4-phosphate by intrinsic susceptibility magnetic resonance imaging.
Journal: International journal of radiation oncology, biology, physics 20071115
Title: Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry.
Journal: Bioorganic & medicinal chemistry 20071101
Title: Design, synthesis, and biological testing of pyrazoline derivatives of combretastatin-A4.
Journal: Bioorganic & medicinal chemistry letters 20071101
Title: Tumour targeting by microtubule-depolymerizing vascular disrupting agents.
Journal: Expert opinion on therapeutic targets 20071101
Title: Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells.
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Title: Combination chemotherapy including combretastatin A4 phosphate and paclitaxel is effective against anaplastic thyroid cancer in a nude mouse xenograft model.
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Title: Novel potent antimitotic heterocyclic ketones: synthesis, antiproliferative activity, and structure-activity relationships.
Journal: Bioorganic & medicinal chemistry letters 20070701
Title: Synthesis and biological activity of naphthalene analogues of phenstatins: naphthylphenstatins.
Journal: Bioorganic & medicinal chemistry letters 20070615
Title: Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies.
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Title: Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization.
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Title: The concise synthesis of chalcone, indanone and indenone analogues of combretastatin A4.
Journal: Bioorganic & medicinal chemistry 20070501
Title: Characterizing the tumor response to treatment with combretastatin A4 phosphate.
Journal: International journal of radiation oncology, biology, physics 20070501
Title: A Ramberg-Bäcklund route to the stilbenoid anti-cancer agents combretastatin A-4 and DMU-212.
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Title: Synthesis and evaluation of 4/5-hydroxy-2,3-diaryl(substituted)-cyclopent-2-en-1-ones as cis-restricted analogues of combretastatin A-4 as novel anticancer agents.
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Title: Tumor antivascular effects of radiotherapy combined with combretastatin a4 phosphate in human non-small-cell lung cancer.
Journal: International journal of radiation oncology, biology, physics 20070401
Title: N-Phenyl-N'-(2-chloroethyl)urea analogues of combretastatin A-4: Is the N-phenyl-N'-(2-chloroethyl)urea pharmacophore mimicking the trimethoxy phenyl moiety?
Journal: Bioorganic & medicinal chemistry letters 20070401
Title: Evaluation of the vascular targeting agent combretastatin a-4 prodrug on retinal neovascularization in the galactose-fed dog.
Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070401
Title: Potent antitubulin tumor cell cytotoxins based on 3-aroyl indazoles.
Journal: Journal of medicinal chemistry 20070308
Title: Novel pyridinyl and pyrimidinylcarbazole sulfonamides as antiproliferative agents.
Journal: Bioorganic & medicinal chemistry letters 20070301
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Journal: Bioorganic & medicinal chemistry letters 20070215
Title: Synthesis and activity of Combretastatin A-4 analogues: 1,2,3-thiadiazoles as potent antitumor agents.
Journal: Bioorganic & medicinal chemistry letters 20070215
Title: MZ3 induces apoptosis in human leukemia cells.
Journal: Cancer chemotherapy and pharmacology 20070201
Title: Early effects of combretastatin-A4 disodium phosphate on tumor perfusion and interstitial fluid pressure.
Journal: Neoplasia (New York, N.Y.) 20070201
Title: Combretastatin CA-4 and combretastatin derivative induce mitotic catastrophe dependent on spindle checkpoint and caspase-3 activation in non-small cell lung cancer cells.
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Title: Dose-response relationship of ultrasound contrast agent in an in vivo murine melanoma model.
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Title: Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization.
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Title: Synthesis and biological properties of bioreductively targeted nitrothienyl prodrugs of combretastatin A-4.
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Journal: Journal of medicinal chemistry 20061019
Title: 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents.
Journal: Journal of medicinal chemistry 20061019
Title: Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors.
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Title: Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416.
Journal: Bioorganic & medicinal chemistry 20061001
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Title: Interaction of 4-arylcoumarin analogues of combretastatins with microtubule network of HBL100 cells and binding to tubulin.
Journal: Biochemistry 20060801
Title: Low-dose combretastatin A4 phosphate enhances the immune response of tumor hosts to experimental colon carcinoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060801
Title: 4,5-Diaryl-1H-pyrrole-2-carboxylates as combretastatin A-4/lamellarin T hybrids: synthesis and evaluation as anti-mitotic and cytotoxic agents.
Journal: Bioorganic & medicinal chemistry 20060701
Title: Synthesis and biological evaluation of (3,4,5-trimethoxyphenyl)indol-3-ylmethane derivatives as potential antivascular agents.
Journal: Bioorganic & medicinal chemistry 20060701
Title: Promising new treatments for neovascular age-related macular degeneration.
Journal: Expert opinion on investigational drugs 20060701
Title: Effect of the second-generation vascular disrupting agent OXi4503 on tumor vascularity.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060701
Title: Early effects of combretastatin A4 phosphate assessed by anatomic and carbogen-based functional magnetic resonance imaging on rat bladder tumors implanted in nude mice.
Journal: Neoplasia (New York, N.Y.) 20060701
Title: Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents.
Journal: Journal of medicinal chemistry 20060629
Title: Isoxazole-type derivatives related to combretastatin A-4, synthesis and biological evaluation.
Journal: Bioorganic & medicinal chemistry 20060615
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Title: Novel combretastatin analogues endowed with antitumor activity.
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Journal: Current opinion in investigational drugs (London, England : 2000) 20060601
Title: A tumor vasculature targeted liposome delivery system for combretastatin A4: design, characterization, and in vitro evaluation.
Journal: AAPS PharmSciTech 20060407
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Journal: Bioorganic & medicinal chemistry letters 20060301
Title: C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties.
Journal: Bioorganic & medicinal chemistry letters 20060101
Title: NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent.
Journal: Anti-cancer drugs 20060101
Title: In vivo antitumour effect of combretastatin A-4 phosphate added to fractionated irradiation.
Journal: Anticancer research 20060101
Title: The effects of the vascular disrupting agents combretastatin A-4 disodium phosphate, 5,6-dimethylxanthenone-4-acetic acid and ZD6126 in a murine tumour: a comparative assessment using MRI and MRS.
Journal: Acta oncologica (Stockholm, Sweden) 20060101
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Journal: Retina (Philadelphia, Pa.) 20060101
Title: Combretastatin A-1 phosphate potentiates the antitumor activity of carboplatin and paclitaxel in a severe combined immunodeficiency disease (SCID) mouse model of human ovarian carcinoma.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20060101
Title: A targeted liposome delivery system for combretastatin A4: formulation optimization through drug loading and in vitro release studies.
Journal: PDA journal of pharmaceutical science and technology 20060101
Title: Anti-vascular agent Combretastatin A-4-P modulates hypoxia inducible factor-1 and gene expression.
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Journal: Bioorganic & medicinal chemistry letters 20051201
Title: Plant-based anticancer molecules: a chemical and biological profile of some important leads.
Journal: Bioorganic & medicinal chemistry 20051101
Title: Effect of vascular targeting agent in rat tumor model: dynamic contrast-enhanced versus diffusion-weighted MR imaging.
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Title: Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling.
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Title: Antineoplastic strategy: irreversible tumor blood flow stasis induced by the combretastatin A-4 derivative AVE8062 (AC7700).
Journal: Chemotherapy 20051001
Title: Antineoplastic agents. 509: synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1).
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Title: Taking down tumors: vascular disrupting agents entering clinical trials.
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Title: Structure-based discovery of a boronic acid bioisostere of combretastatin A-4.
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Title: Stilbenophane analogues of deoxycombretastatin A-4.
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Title: Antineoplastic agents. 515. Synthesis of human cancer cell growth inhibitors derived from 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene.
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Title: Diffusion-weighted magnetic resonance imaging allows noninvasive in vivo monitoring of the effects of combretastatin a-4 phosphate after repeated administration.
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Title: Tumour parameters affected by combretastatin A-4 phosphate therapy in a human colorectal xenograft model in nude mice.
Journal: European journal of cancer (Oxford, England : 1990) 20050301
Title: Antimitotic activity and reversal of breast cancer resistance protein-mediated drug resistance by stilbenoids from Bletilla striata.
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Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050215
Title: Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines.
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Journal: Investigative ophthalmology & visual science 20050101
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Journal: Anticancer research 20050101
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Title: The tubulin-binding agent combretastatin A-4-phosphate arrests endothelial cells in mitosis and induces mitotic cell death.
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Title: Consideration of QT/QTc interval data in a phase I study in patients with advanced cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040901
Title: Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents.
Journal: Journal of medicinal chemistry 20040812
Title: A new family of quinoline and quinoxaline analogues of combretastatins.
Journal: Bioorganic & medicinal chemistry letters 20040716
Title: Vascular-targeting therapies for treatment of malignant disease.
Journal: Cancer 20040615
Title: Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents.
Journal: Journal of medicinal chemistry 20040520
Title: Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue design.
Journal: Bioorganic & medicinal chemistry letters 20040503
Title: Combretastatin A4 phosphate.
Journal: Anti-cancer drugs 20040301
Title: Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040215
Title: Induction of tumour blood flow stasis and necrosis: a new function for epinephrine similar to that of combretastatin A-4 derivative AVE8062 (AC7700).
Journal: British journal of cancer 20040126
Title: Vascular targeting agents as cancer therapeutics.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040115
Title: Combretastatin A-4 phosphate enhances CPT-11 activity independently of the administration sequence.
Journal: European journal of cancer (Oxford, England : 1990) 20040101
Title: Cardiovascular safety profile of combretastatin a4 phosphate in a single-dose phase I study in patients with advanced cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040101
Title: Abilities of 3,4-diarylfuran-2-one analogs of combretastatin A-4 to inhibit both proliferation of tumor cell lines and growth of relevant tumors in nude mice.
Journal: Anticancer research 20040101
Title: Synthesis and biological evaluation of 4-arylcoumarin analogues of combretastatins.
Journal: Journal of medicinal chemistry 20031204
Title: Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: magnetic resonance imaging evidence for altered tumor blood flow.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20031201
Title: Thrombosis and Hemostasis Issues in Cancer - Second International Conference. 19-21 September, 2003, Bergamo, Italy.
Journal: IDrugs : the investigational drugs journal 20031101
Title: Combretastatin A-4 analogues as antimitotic antitumor agents.
Journal: Current medicinal chemistry 20030901
Title: Antitumor activity of TZT-1027 (Soblidotin) against vascular endothelial growth factor-secreting human lung cancer in vivo.
Journal: Cancer science 20030901
Title: Assessment of pharmacodynamic vascular response in a phase I trial of combretastatin A4 phosphate.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030801
Title: Combretastatin A4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030801
Title: Combretastatin A-4 phosphate suppresses development and induces regression of choroidal neovascularization.
Journal: Investigative ophthalmology & visual science 20030801
Title: Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal: Journal of medicinal chemistry 20030717
Title: (E)-1-(2-Hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene.
Journal: Acta crystallographica. Section C, Crystal structure communications 20030701
Title: Vascular targeting effect of combretastatin A-4 phosphate dominates the inherent angiogenesis inhibitory activity.
Journal: International journal of cancer 20030520
Title: Novel 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues as cytotoxic agents.
Journal: Bioorganic & medicinal chemistry letters 20030519
Title: Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4.
Journal: Bioorganic & medicinal chemistry letters 20030505
Title: Synthesis, anticancer activity, and inhibition of tubulin polymerization by conformationally restricted analogues of lavendustin A.
Journal: Journal of medicinal chemistry 20030424
Title: Antineoplastic agents. 487. Synthesis and biological evaluation of the antineoplastic agent 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene and derived amino acid amides.
Journal: Journal of medicinal chemistry 20030213
Title: Structure-activity and crystallographic analysis of benzophenone derivatives-the potential anticancer agents.
Journal: Bioorganic & medicinal chemistry letters 20030106
Title: Evaluation of antimitotic agents by quantitative comparisons of their effects on the polymerization of purified tubulin.
Journal: Cell biochemistry and biophysics 20030101
Title: Vascular targeting: a potential additional anti-cancer treatment.
Journal: Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie 20030101
Title: Oxi4503, a novel vascular targeting agent: effects on blood flow and antitumor activity in comparison to combretastatin A-4 phosphate.
Journal: Anticancer research 20030101
Title: The vascular targeting agent combretastatin A-4-phosphate induces neutrophil recruitment to endothelial cells in vitro.
Journal: Anticancer research 20030101
Title: Drug based approaches for targeting tumor vasculature: development of combretastatin A4 phosphate.
Journal: Pathophysiology of haemostasis and thrombosis 20030101
Title: The development of combretastatin A4 phosphate as a vascular targeting agent.
Journal: International journal of radiation oncology, biology, physics 20021201
Title: Combination of vascular targeting agents with thermal or radiation therapy.
Journal: International journal of radiation oncology, biology, physics 20021201
Title: Enhancement of vascular targeting by inhibitors of nitric oxide synthase.
Journal: International journal of radiation oncology, biology, physics 20021201
Title: Combretastatin A4 phosphate has primary antineoplastic activity against human anaplastic thyroid carcinoma cell lines and xenograft tumors.
Journal: Thyroid : official journal of the American Thyroid Association 20021201
Title: Schedule dependence of combretastatin A4 phosphate in transplanted and spontaneous tumour models.
Journal: International journal of cancer 20021101
Title: The vascular response of tumor and normal tissues in the rat to the vascular targeting agent, combretastatin A-4-phosphate, at clinically relevant doses.
Journal: International journal of oncology 20021001
Title: Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020801
Title: A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer.
Journal: Cancer research 20020615
Title: Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate.
Journal: Journal of medicinal chemistry 20020606
Title: Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents.
Journal: Journal of medicinal chemistry 20020606
Title: One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization.
Journal: Journal of medicinal chemistry 20020606
Title: Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy.
Journal: International journal of cancer 20020501
Title: Acute effects of vascular modifying agents in solid tumors assessed by noninvasive laser Doppler flowmetry and near infrared spectroscopy.
Journal: Neoplasia (New York, N.Y.) 20020501
Title: The influence of combretastatin A-4 and vinblastine on interstitial fluid pressure in BT4An rat gliomas.
Journal: Cancer letters 20020425
Title: Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation.
Journal: Journal of medicinal chemistry 20020411
Title: Differential sensitivity of two adenocarcinoma xenografts to the anti-vascular drugs combretastatin A4 phosphate and 5,6-dimethylxanthenone-4-acetic acid, assessed using MRI and MRS.
Journal: NMR in biomedicine 20020401
Title: Inhibition of proliferative retinopathy by the anti-vascular agent combretastatin-A4.
Journal: The American journal of pathology 20020301
Title: Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent.
Journal: Bioorganic & medicinal chemistry letters 20020211
Title: The biology of the combretastatins as tumour vascular targeting agents.
Journal: International journal of experimental pathology 20020201
Title: Preclinical evaluations of therapies combining the vascular targeting agent combretastatin A-4 disodium phosphate and conventional anticancer therapies in the treatment of Kaposi's sarcoma.
Journal: Acta oncologica (Stockholm, Sweden) 20020101
Title: Activity of the vascular targeting agent combretastatin A-4 disodium phosphate in a xenograft model of AIDS-associated Kaposi's sarcoma.
Journal: Acta oncologica (Stockholm, Sweden) 20020101
Title: Anti-tumor and anti-vascular effects of the novel tubulin-binding agent combretastatin A-1 phosphate.
Journal: Anticancer research 20020101
Title: Critical assessment of angiogenesis inhibitors in clinical trials.
Journal: I supplementi di Tumori : official journal of Societa italiana di cancerologia ... [et al.] 20020101
Title: Tumor vasculature is targeted by the combination of combretastatin A-4 and hyperthermia.
Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20011201
Title: Novel syntheses of cis and trans isomers of combretastatin A-4.
Journal: The Journal of organic chemistry 20011130
Title: Combretastatin A-4 disodium phosphate: a vascular targeting agent that improves that improves the anti-tumor effects of hyperthermia, radiation, and mild thermoradiotherapy.
Journal: International journal of radiation oncology, biology, physics 20011115
Title: Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents.
Journal: Journal of medicinal chemistry 20011108
Title: Potent anti-metastatic activity of combretastatin-A4.
Journal: International journal of oncology 20011001
Title: The susceptibility of tumors to the antivascular drug combretastatin A4 phosphate correlates with vascular permeability.
Journal: Cancer research 20010915
Title: The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4.
Journal: Bioorganic & medicinal chemistry letters 20010903
Title: Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability.
Journal: Cancer research 20010901
Title: Combretastatin A-4 and hyperthermia;a potent combination for the treatment of solid tumors.
Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20010801
Title: Interaction between combretastatin A-4 disodium phosphate and radiation in murine tumors.
Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20010801
Title: Eradication of colorectal xenografts by combined radioimmunotherapy and combretastatin a-4 3-O-phosphate.
Journal: Cancer research 20010615
Title: Combretastatin A-4 prodrug inhibits growth of human non-small cell lung cancer in a murine xenotransplant model.
Journal: The Annals of thoracic surgery 20010501
Title: Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents.
Journal: Bioorganic & medicinal chemistry letters 20010409
Title: Combretastatin A4 prodrug study of effect on the growth and the microvasculature of colorectal liver metastases in a murine model.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010401
Title: Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum.
Journal: Cancer gene therapy 20010401
Title: Combretastatin-A4 disrupts neovascular development in non-neoplastic tissue.
Journal: British journal of cancer 20010301
Title: Improvement of Clostridium tumour targeting vectors evaluated in rat rhabdomyosarcomas.
Journal: FEMS immunology and medical microbiology 20010201
Title: In vivo antitumor effect of vascular targeting combined with either ionizing radiation or anti-angiogenesis treatment.
Journal: International journal of radiation oncology, biology, physics 20010201
Title: Comparative effects of combretastatin A-4 disodium phosphate and 5,6-dimethylxanthenone-4-acetic acid on blood perfusion in a murine tumour and normal tissues.
Journal: International journal of radiation biology 20010201
Title: Design, synthesis, and biological evaluation of a series of lavendustin A analogues that inhibit EGFR and Syk tyrosine kinases, as well as tubulin polymerization.
Journal: Journal of medicinal chemistry 20010201
Title: Targeting tumour vasculature: the development of combretastatin A4.
Journal: The Lancet. Oncology 20010201
Title: Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
Journal: Bioorganic & medicinal chemistry letters 20010108
Title: Combretastatin A-4 and doxorubicin combination treatment is effective in a preclinical model of human medullary thyroid carcinoma.
Journal: Oncology reports 20010101
Title: Stoppage of blood flow in 3-methylcholanthrene-induced autochthonous primary tumor due to a novel combretastatin A-4 derivative, AC7700, and its antitumor effect.
Journal: Medical science monitor : international medical journal of experimental and clinical research 20010101
Title: Evaluation of combretastatin A-4 prodrug in a non-Hodgkin's lymphoma xenograft model: preclinical efficacy.
Journal: Anti-cancer drugs 20010101
Title: Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo.
Journal: Anticancer research 20010101
Title: 6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Journal: Journal of medicinal chemistry 20001116
Title: Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4.
Journal: Experientia 19890215
Title: Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.
Journal: Molecular pharmacology 19880801
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