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221877-54-9,MFCD09752954
Catalog No.:AA00BF5C

221877-54-9 | Zotarolimus

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1mg
≥95% (mixture of isomers)
in stock  
$46.00   $32.00
- +
5mg
≥95% (mixture of isomers)
in stock  
$133.00   $93.00
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10mg
≥95% (mixture of isomers)
in stock  
$242.00   $169.00
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25mg
≥95% (mixture of isomers)
in stock  
$490.00   $343.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BF5C
Chemical Name:
Zotarolimus
CAS Number:
221877-54-9
Molecular Formula:
C52H79N5O12
Molecular Weight:
966.2100
MDL Number:
MFCD09752954
SMILES:
CO[C@@H]1C[C@@H](CC[C@@H]1n1cnnn1)C[C@H]([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H](CC[C@H]2C)C[C@H](OC)/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C1)C)/C)O)OC)C)C)/C)C
Properties
Computed Properties
 
Complexity:
1890  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
15  
Defined Bond Stereocenter Count:
4  
Heavy Atom Count:
69  
Hydrogen Bond Acceptor Count:
15  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
5.9  

Literature

Title: Endothelial progenitor cell response to antiproliferative drug exposure.

Journal: Atherosclerosis 20121101

Title: Stent thrombosis and major clinical events at 3 years after zotarolimus-eluting or sirolimus-eluting coronary stent implantation: a randomised, multicentre, open-label, controlled trial.

Journal: Lancet (London, England) 20121020

Title: A new strategy for discontinuation of dual antiplatelet therapy: the RESET Trial (REal Safety and Efficacy of 3-month dual antiplatelet Therapy following Endeavor zotarolimus-eluting stent implantation).

Journal: Journal of the American College of Cardiology 20121009

Title: Comparison of twelve-month outcomes after percutanous coronary intervention with everolimus-eluting versus zotarolimus-eluting or sirolimus-eluting stents from the PROENCY (PROmus ENdeavor CYpher) registry.

Journal: The Journal of invasive cardiology 20121001

Title: Vascular healing in drug-eluting stents: differential drug-associated response of limus-eluting stents in a preclinical model of stent implantation.

Journal: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20121001

Title: Unprotected left main coronary artery stenting with zotarolimus (Endeavor) drug-eluting stents: a single center retrospective experience.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20120801

Title: Optical coherence tomographic comparison of neointimal coverage between sirolimus- and resolute zotarolimus-eluting stents at 9 months after stent implantation.

Journal: The international journal of cardiovascular imaging 20120801

Title: Frequency and impact of bleeding in elective coronary stent clinical trials--utility of three commonly used definitions.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20120801

Title: Comparative assessment of transient exposure of paclitaxel or zotarolimus on in vitro vascular cell death, proliferation, migration, and proinflammatory biomarker expression.

Journal: Journal of cardiovascular pharmacology 20120801

Title: Short- and long-term outcomes with drug-eluting and bare-metal coronary stents: a mixed-treatment comparison analysis of 117 762 patient-years of follow-up from randomized trials.

Journal: Circulation 20120612

Title: Inhibition of neointimal hyperplasia with a novel zotarolimus coated balloon catheter.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20120601

Title: Gender differences in patients treated with the zotarolimus-eluting stent at a tertiary medical center.

Journal: The Journal of invasive cardiology 20120601

Title: Limus is not limus--a proposal to adjust terminology in the context of drug-eluting stents.

Journal: Journal of cardiovascular pharmacology 20120501

Title: Short- versus long-term duration of dual-antiplatelet therapy after coronary stenting: a randomized multicenter trial.

Journal: Circulation 20120424

Title: A randomized controlled trial in second-generation zotarolimus-eluting Resolute stents versus everolimus-eluting Xience V stents in real-world patients: the TWENTE trial.

Journal: Journal of the American College of Cardiology 20120410

Title: Major determinants for the uncovered stent struts on optical coherence tomography after drug-eluting stent implantation.

Journal: The international journal of cardiovascular imaging 20120401

Title: Optical coherence tomography findings of very late stent thrombosis after drug-eluting stent implantation.

Journal: The international journal of cardiovascular imaging 20120401

Title: DUrable polymer-based sTent CHallenge of Promus ElemEnt versus ReSolute integrity (DUTCH PEERS): rationale and study design of a randomized multicenter trial in a Dutch all-comers population.

Journal: American heart journal 20120401

Title: ComparisOn of neointimal coVerage betwEen zotaRolimus-eluting stent and everolimus-eluting stent using Optical Coherence Tomography (COVER OCT).

Journal: American heart journal 20120401

Title: Resolute Italian study in all comers: immediate and one-year outcomes.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20120301

Title: One-year outcomes of patients with the zotarolimus-eluting coronary stent: RESOLUTE International Registry.

Journal: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20120201

Title: A case of subacute thrombosis associated with clopidogrel resistance after implantation of a zotarolimus-eluting stent.

Journal: Heart and vessels 20120101

Title: Randomized comparison of the efficacy and safety of zotarolimus-eluting stents vs. sirolimus-eluting stents for percutaneous coronary intervention in chronic total occlusion--CAtholic Total Occlusion Study (CATOS) trial.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20120101

Title: Clinical outcomes after treatment of multiple lesions with zotarolimus-eluting versus sirolimus-eluting coronary stents (a SORT OUT III substudy).

Journal: BMC cardiovascular disorders 20120101

Title: The 'Harmonizing Optimal Strategy for Treatment of coronary artery stenosis - sAfety & effectiveneSS of drug-elUting stents & antiplatelet REgimen' (HOST-ASSURE) trial: study protocol for a randomized controlled trial.

Journal: Trials 20120101

Title: Outcomes of patients treated with the everolimus-eluting stent versus the zotarolimus eluting stent in a consecutive cohort of patients at a tertiary medical center.

Journal: Vascular health and risk management 20120101

Title: Comparison of pharmacokinetics of the limus-eluting stents in Japanese patients.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20111201

Title: Comparison of zotarolimus- versus everolimus-eluting stents in the treatment of coronary bifurcation lesions.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20111201

Title: Three-year clinical outcome with the Endeavor™ zotarolimus-eluting stent in primary percutaneous coronary intervention for ST elevation myocardial infarction: the Endeavor™ primary PCI study (E-PPCI).

Journal: Journal of interventional cardiology 20111201

Title: Comparison of zotarolimus-eluting stents versus sirolimus-eluting stents versus paclitaxel-eluting stents for primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction: results from the Korean Multicentre Endeavor (KOMER) acute myocardial infarction (AMI) trial.

Journal: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20111201

Title: Bifurcation stenting with a provisional T strategy: drug eluting stent type does matter.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20111201

Title: Risk of target lesion failure in relationship to vessel angiographic geometry and stent conformability using the second generation of drug-eluting stents.

Journal: American heart journal 20111201

Title: Differences in drug-eluting stents used in coronary artery disease.

Journal: The American journal of the medical sciences 20111101

Title: Outcome of sirolimus-eluting versus zotarolimus-eluting coronary stent implantation in patients with and without diabetes mellitus (a SORT OUT III Substudy).

Journal: The American journal of cardiology 20111101

Title: Clinical outcome of B2/C type isolated proximal LAD disease treated with drug-eluting stents.

Journal: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20111101

Title: Tissue coverage of a hydrophilic polymer-coated zotarolimus-eluting stent vs. a fluoropolymer-coated everolimus-eluting stent at 13-month follow-up: an optical coherence tomography substudy from the RESOLUTE All Comers trial.

Journal: European heart journal 20111001

Title: Sex differences in neointimal hyperplasia following endeavor zotarolimus-eluting stent implantation.

Journal: The American journal of cardiology 20111001

Title: Evaluation of zotarolimus-eluting metal stent in animal ureters.

Journal: Journal of endourology 20111001

Title: Vascular response to zotarolimus-coated balloons in injured superficial femoral arteries of the familial hypercholesterolemic Swine.

Journal: Circulation. Cardiovascular interventions 20111001

Title: Dual antiplatelet therapy duration and clinical outcomes following treatment with zotarolimus-eluting stents.

Journal: JACC. Cardiovascular interventions 20111001

Title: Will we ever know the optimal duration of dual antiplatelet therapy after drug-eluting stent implantation?

Journal: JACC. Cardiovascular interventions 20111001

Title: Real world clinical performance of the zotarolimus eluting coronary stent system in Chinese patients: a prospective, multicenter registry study.

Journal: Chinese medical journal 20111001

Title: Telmisartan reduces neointima volume and pulse wave velocity 8 months after zotarolimus-eluting stent implantation in hypertensive type 2 diabetic patients.

Journal: Heart (British Cardiac Society) 20110901

Title: [Zotarolimus-eluting stent].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20110901

Title: Polymer-free sirolimus- and probucol-eluting versus new generation zotarolimus-eluting stents in coronary artery disease: the Intracoronary Stenting and Angiographic Results: Test Efficacy of Sirolimus- and Probucol-Eluting versus Zotarolimus-eluting Stents (ISAR-TEST 5) trial.

Journal: Circulation 20110802

Title: Should stent selection in diabetic patients be considered as a special case?

Journal: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20110701

Title: Late lumen loss and intima hyperplasia after sirolimus-eluting and zotarolimus-eluting stent implantation in diabetic patients: the diabetes and drug-eluting stent (DiabeDES III) angiography and intravascular ultrasound trial.

Journal: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20110701

Title: Impact of drug release kinetics on vascular response to different zotarolimus-eluting stents implanted in patients with long coronary stenoses: the LongOCT study (Optical Coherence Tomography in Long Lesions).

Journal: JACC. Cardiovascular interventions 20110701

Title: Linking drug-eluting stent kinetics and clinical outcomes: insights from optical coherence tomography.

Journal: JACC. Cardiovascular interventions 20110701

Title: Extended follow-up safety and effectiveness of the Endeavor zotarolimus-eluting stent in real-world clinical practice: two-year follow-up from the E-Five Registry.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20110601

Title: Endothelium-dependent coronary vasomotor response and neointimal coverage of zotarolimus-eluting stents 3 months after implantation.

Journal: Heart (British Cardiac Society) 20110601

Title: Impact of polymer formulations on neointimal proliferation after zotarolimus-eluting stent with different polymers: insights from the RESOLUTE trial.

Journal: Circulation. Cardiovascular interventions 20110601

Title: Comparison of titanium-nitride-oxide-coated stents with zotarolimus-eluting stents for coronary revascularization a randomized controlled trial.

Journal: JACC. Cardiovascular interventions 20110601

Title: The impact of patient and lesion complexity on clinical and angiographic outcomes after revascularization with zotarolimus- and everolimus-eluting stents: a substudy of the RESOLUTE All Comers Trial (a randomized comparison of a zotarolimus-eluting stent with an everolimus-eluting stent for percutaneous coronary intervention).

Journal: Journal of the American College of Cardiology 20110531

Title: Clinical outcomes by geographic region for patients implanted with the zotarolimus-eluting stent.

Journal: Arquivos brasileiros de cardiologia 20110501

Title: Rationale and design of the clinical evaluation of the Resolute Zotarolimus-Eluting Coronary Stent System in the treatment of de novo lesions in native coronary arteries (the RESOLUTE US clinical trial).

Journal: American heart journal 20110501

Title: Late-term clinical outcomes with zotarolimus- and sirolimus-eluting stents. 5-year follow-up of the ENDEAVOR III (A Randomized Controlled Trial of the Medtronic Endeavor Drug [ABT-578] Eluting Coronary Stent System Versus the Cypher Sirolimus-Eluting Coronary Stent System in De Novo Native Coronary Artery Lesions).

Journal: JACC. Cardiovascular interventions 20110501

Title: My stent is better than your stent...Or is it?

Journal: JACC. Cardiovascular interventions 20110501

Title: Clinical evaluation of the Resolute zotarolimus-eluting coronary stent system in the treatment of de novo lesions in native coronary arteries: the RESOLUTE US clinical trial.

Journal: Journal of the American College of Cardiology 20110426

Title: Clinical outcome, angiographic outcome, and coronary endothelial function after drug-eluting stent implantation.

Journal: Journal of the American College of Cardiology 20110412

Title: Unrestricted randomised use of two new generation drug-eluting coronary stents: 2-year patient-related versus stent-related outcomes from the RESOLUTE All Comers trial.

Journal: Lancet (London, England) 20110409

Title: Long-term safety and efficacy of drug-eluting stents.

Journal: Lancet (London, England) 20110409

Title: Novel approaches for preventing or limiting events in diabetic patients (Naples-diabetes) trial: a randomized comparison of 3 drug-eluting stents in diabetic patients.

Journal: Circulation. Cardiovascular interventions 20110401

Title: Comparison of zotarolimus-eluting stents with sirolimus-eluting and paclitaxel-eluting stents: intimal hyperplasia and vascular changes assessed by volumetric intravascular ultrasound analysis.

Journal: Circulation. Cardiovascular interventions 20110401

Title: The prognostic utility of the SYNTAX score on 1-year outcomes after revascularization with zotarolimus- and everolimus-eluting stents: a substudy of the RESOLUTE All Comers Trial.

Journal: JACC. Cardiovascular interventions 20110401

Title: Stent fracture and restenosis after zotarolimus-eluting stent implantation.

Journal: International journal of cardiology 20110303

Title: Comparative assessment of mammalian target of rapamycin inhibitor-eluting stents in the treatment of coronary artery bifurcation lesions: the CASTOR-Bifurcation registry.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20110301

Title: Spatial distribution of neo-intimal hyperplasia 6 months after zotarolimus-eluting stent implantation, analysed by optical coherence tomography.

Journal: Archives of cardiovascular diseases 20110301

Title: A prospective multicenter parallel-controlled trial of TIVOLI biodegradable-polymer-based sirolimus-eluting stent compared to ENDEAVOR zotarolimus-eluting stent for the treatment of coronary artery disease: 8-month angiographic and 2-year clinical follow-up results.

Journal: Chinese medical journal 20110301

Title: [Determination of the content of zotarolimus on the drug eluting stents by HPLC].

Journal: Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation 20110301

Title: Procedural and clinical evaluation of the novel zotarolimus-eluting resolute stent in patients with unselected bifurcated coronary stenosis treated by provisional approach: a multicenter registry.

Journal: The Journal of invasive cardiology 20110201

Title: Resolute™ drug-eluting stent: a resolution for bifurcation lesions?

Journal: The Journal of invasive cardiology 20110201

Title: [Types and characteristic features of drug-eluting stents].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20110201

Title: Drug-eluting stents for the treatment of pulmonary vein stenosis after atrial fibrillation ablation.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20110101

Title: The relationship between late lumen loss and restenosis among various drug-eluting stents: a systematic review and meta-regression analysis of randomized clinical trials.

Journal: Atherosclerosis 20110101

Title: Two-year outcome of Turkish patients treated with Zotarolimus versus Paclitaxel eluting stents in an unselected population with coronary artery disease in the real world: a prospective non-randomized registry in southern Turkey.

Journal: International journal of medical sciences 20110101

Title: The clinical evaluation of the Endeavor zotarolimus-eluting coronary stent in Japanese patients with de novo native coronary artery lesions: primary results and 3-year follow-up of the Endeavor Japan study.

Journal: Cardiovascular revascularization medicine : including molecular interventions 20110101

Title: The impact of new generation drug-eluting stent implantation on patients with chronic kidney disease and a single lesion in the proximal segment of the left anterior descending artery.

Journal: Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20110101

Title: Comparison of paclitaxel-, sirolimus-, and zotarolimus-eluting stents in patients with acute ST-segment elevation myocardial infarction and metabolic syndrome.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20110101

Title: Cellular and molecular changes associated with inhibitory effect of pioglitazone on neointimal growth in patients with type 2 diabetes after zotarolimus-eluting stent implantation.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20101201

Title: Long-term clinical outcomes with zotarolimus-eluting versus bare-metal coronary stents.

Journal: JACC. Cardiovascular interventions 20101201

Title: Sex-specific outcomes following revascularization with zotarolimus-eluting stents: comparison of angiographic and late-term clinical results.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20101115

Title: Gender medicine and drug eluting coronary stents.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20101115

Title: Comparison of vascular response to zotarolimus-eluting stent vs paclitaxel-eluting stent implantation: pooled IVUS results from the ZoMaxx I and II trials.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20101101

Title: Three-month dual antiplatelet therapy after implantation of zotarolimus-eluting stents: the DATE (Duration of Dual Antiplatelet Therapy AfterImplantation of Endeavor Stent) registry.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20101101

Title: Long-term follow-up of the randomised controlled trial to evaluate the safety and efficacy of the zotarolimus-eluting driver coronary stent in de novo native coronary artery lesions: five year outcomes in the ENDEAVOR II study.

Journal: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20101101

Title: Neovascular microchannels in sirolimus-eluting stent occlusion at late phase.

Journal: JACC. Cardiovascular interventions 20101101

Title: Comparison of zotarolimus-eluting stents with sirolimus- and paclitaxel-eluting stents for coronary revascularization: the ZEST (comparison of the efficacy and safety of zotarolimus-eluting stent with sirolimus-eluting and paclitaxel-eluting stent for coronary lesions) randomized trial.

Journal: Journal of the American College of Cardiology 20101005

Title: Short- and mid-term intravascular ultrasound analysis of the new zotarolimus-eluting stent with durable polymer – results from the RESOLUTE trial –.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20101001

Title: Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial.

Journal: Heart (British Cardiac Society) 20101001

Title: Paclitaxel-coated balloons - Survey of preclinical data.

Journal: Minerva cardioangiologica 20101001

Title: Two-year clinical outcomes after large coronary stent (4.0 mm) placement: comparison of bare-metal stent versus drug-eluting stent.

Journal: Clinical cardiology 20101001

Title: Improved late clinical safety with zotarolimus-eluting stents compared with paclitaxel-eluting stents in patients with de novo coronary lesions: 3-year follow-up from the ENDEAVOR IV (Randomized Comparison of Zotarolimus- and Paclitaxel-Eluting Stents in Patients With Coronary Artery Disease) trial.

Journal: JACC. Cardiovascular interventions 20101001

Title: Comparison of zotarolimus-eluting and everolimus-eluting coronary stents.

Journal: The New England journal of medicine 20100708

Title: Development and performance of the zotarolimus-eluting Endeavor coronary stent.

Journal: Expert review of medical devices 20100701

Title: Twelve-month outcomes in patients with diabetes implanted with a zotarolimus-eluting stent: results from the E-Five Registry.

Journal: Heart (British Cardiac Society) 20100601

Title: Procedure-related myonecrosis after bare and drug-eluting stent implantation.

Journal: Asian cardiovascular & thoracic annals 20100601

Title: Clinical and angiographic outcomes of drug-eluting stents in patients with large vessel and single coronary artery lesion.

Journal: Clinical cardiology 20100601

Title: A randomised comparison of novolimus-eluting and zotarolimus-eluting coronary stents: 9-month follow-up results of the EXCELLA II study.

Journal: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20100601

Title: Strut coverage and vessel wall response to zotarolimus-eluting and bare-metal stents implanted in patients with ST-segment elevation myocardial infarction: the OCTAMI (Optical Coherence Tomography in Acute Myocardial Infarction) Study.

Journal: JACC. Cardiovascular interventions 20100601

Title: The initial extent of malapposition in ST-elevation myocardial infarction treated with drug-eluting stent: the usefulness of optical coherence tomography.

Journal: Yonsei medical journal 20100501

Title: Optical coherence tomography assessment of in vivo vascular response after implantation of overlapping bare-metal and drug-eluting stents.

Journal: JACC. Cardiovascular interventions 20100501

Title: Eighteen-month clinical safety and efficacy outcomes of sirolimus-, paclitaxel- and zotarolimus-drug eluting stents in diabetic patients undergoing percutaneous coronary intervention for complex coronary artery stenosis.

Journal: Annals of the Academy of Medicine, Singapore 20100501

Title: In-hospital and 12-month postprocedural clinical outcome of coronary bifurcational lesion treatment with the endeavor stent.

Journal: Journal of interventional cardiology 20100401

Title: Efficacy and safety of zotarolimus-eluting and sirolimus-eluting coronary stents in routine clinical care (SORT OUT III): a randomised controlled superiority trial.

Journal: Lancet (London, England) 20100327

Title: Sorting out drug-eluting stents.

Journal: Lancet (London, England) 20100327

Title: Comparison of outcomes between Zotarolimus- and sirolimus-eluting stents in patients with ST-segment elevation acute myocardial infarction.

Journal: The American journal of cardiology 20100315

Title: A randomized comparison of the Endeavor zotarolimus-eluting stent versus the TAXUS paclitaxel-eluting stent in de novo native coronary lesions 12-month outcomes from the ENDEAVOR IV trial.

Journal: Journal of the American College of Cardiology 20100209

Title: Cost-effectiveness of the Endeavor stent in de novo native coronary artery lesions updated with contemporary data.

Journal: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20100201

Title: Rapamycin promotes arterial thrombosis in vivo: implications for everolimus and zotarolimus eluting stents.

Journal: European heart journal 20100101

Title: Small coronary vessel angioplasty: outcomes and technical considerations.

Journal: Vascular health and risk management 20100101

Title: Clinical studies with sirolimus, zotarolimus, everolimus, and biolimus A9 drug-eluting stent systems.

Journal: Current pharmaceutical design 20100101

Title: Histopathology of clinical coronary restenosis in drug-eluting versus bare metal stents.

Journal: The American journal of cardiology 20091215

Title: Structural identification and characterization of potential degradants of zotarolimus on zotarolimus-coated drug-eluting stents.

Journal: Journal of pharmaceutical and biomedical analysis 20091205

Title: Optical coherence tomography evaluation of zotarolimus-eluting stents at 9-month follow-up: comparison with sirolimus-eluting stents.

Journal: Heart (British Cardiac Society) 20091201

Title: Lack of clinical benefit of improved angiographic results with sirolimus-eluting stents compared with paclitaxel and zotarolimus-eluting stents in patients with acute myocardial infarction undergoing percutaneous coronary intervention.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20091201

Title: Five-year clinical follow-up after implantation of the Endeavor zotarolimus-eluting stent: ENDEAVOR I, first-in-human study.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20091201

Title: The long-term results of the 'Endeavor' stent.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20091201

Title: Rationale and design of the Patient Related OuTcomes with Endeavor versus Cypher stenting Trial (PROTECT): randomized controlled trial comparing the incidence of stent thrombosis and clinical events after sirolimus or zotarolimus drug-eluting stent implantation.

Journal: American heart journal 20091201

Title: Long-term clinical and economic analysis of the Endeavor zotarolimus-eluting stent versus the cypher sirolimus-eluting stent: 3-year results from the ENDEAVOR III trial (Randomized Controlled Trial of the Medtronic Endeavor Drug [ABT-578] Eluting Coronary Stent System Versus the Cypher Sirolimus-Eluting Coronary Stent System in De Novo Native Coronary Artery Lesions).

Journal: JACC. Cardiovascular interventions 20091201

Title: Late safety, efficacy, and cost-effectiveness of a zotarolimus-eluting stent compared with a paclitaxel-eluting stent in patients with de novo coronary lesions: 2-year follow-up from the ENDEAVOR IV trial (Randomized, Controlled Trial of the Medtronic Endeavor Drug [ABT-578] Eluting Coronary Stent System Versus the Taxus Paclitaxel-Eluting Coronary Stent System in De Novo Native Coronary Artery Lesions).

Journal: JACC. Cardiovascular interventions 20091201

Title: Safety and effectiveness of the Endeavor zotarolimus-eluting stent in real-world clinical practice: 12-month data from the E-Five registry.

Journal: JACC. Cardiovascular interventions 20091201

Title: Evaluation in 3 months duration of neointimal coverage after zotarolimus-eluting stent implantation by optical coherence tomography: the ENDEAVOR OCT trial.

Journal: JACC. Cardiovascular interventions 20091201

Title: Comparison of the efficacy and safety of zotarolimus-, sirolimus-, and paclitaxel-eluting stents in patients with ST-elevation myocardial infarction.

Journal: The American journal of cardiology 20091115

Title: Clinical and angiographic outcomes in diabetics from the ENDEAVOR IV trial: randomized comparison of zotarolimus- and paclitaxel-eluting stents in patients with coronary artery disease.

Journal: JACC. Cardiovascular interventions 20091001

Title: Clinical and angiographic results with the next-generation resolute stent system: a prospective, multicenter, first-in-human trial.

Journal: JACC. Cardiovascular interventions 20091001

Title: A generation 2.5 drug-eluting stent?

Journal: JACC. Cardiovascular interventions 20091001

Title: Intravascular ultrasound results from the ENDEAVOR IV trial: randomized comparison between zotarolimus- and paclitaxel-eluting stents in patients with coronary artery disease.

Journal: JACC. Cardiovascular interventions 20090801

Title: Angiographic and intravascular ultrasound findings following implantation of the Endeavor zotarolimus-eluting stents in patients from the real-world clinical practice.

Journal: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20090801

Title: Different vascular response to concurrent implantation of sirolimus- and zotarolimus-eluting stents in the same vessel.

Journal: Heart and vessels 20090701

Title: A prospective, randomized, 6-month comparison of the coronary vasomotor response associated with a zotarolimus- versus a sirolimus-eluting stent: differential recovery of coronary endothelial dysfunction.

Journal: Journal of the American College of Cardiology 20090505

Title: Differences in restenosis rate with different drug-eluting stents in patients with and without diabetes mellitus: a report from the SCAAR (Swedish Angiography and Angioplasty Registry).

Journal: Journal of the American College of Cardiology 20090505

Title: Correlation between quantitative angiographic and intravascular ultrasound parameters in patients treated with sirolimus analogous-eluting stents.

Journal: The international journal of cardiovascular imaging 20090401

Title: Zotarolimus for the treatment of coronary artery disease: pathophysiology, DES design, clinical evaluation and future perspective.

Journal: Expert opinion on pharmacotherapy 20090401

Title: Frequency and clinical consequences associated with sidebranch occlusion during stent implantation using zotarolimus-eluting and paclitaxel-eluting coronary stents.

Journal: Circulation. Cardiovascular interventions 20090401

Title: Optical coherence tomography to diagnose under-expansion of a drug-eluting stent.

Journal: JACC. Cardiovascular imaging 20090201

Title: Long-term follow-up of percutaneous coronary intervention of unprotected left main lesions with drug eluting stents: predictors of clinical outcome.

Journal: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20090101

Title: [Economic evaluation and budget impact analysis of the Endeavor drug-eluting stent in Spain].

Journal: Gaceta sanitaria 20090101

Title: Comparative analysis of neointimal coverage with paclitaxel and zotarolimus drug-eluting stents, using optical coherence tomography 6 months after implantation.

Journal: Archives of cardiovascular diseases 20090101

Title: Fracture of zotarolimus-eluting stent after implantation.

Journal: Texas Heart Institute journal 20090101

Title: Is there a preferable DES in diabetic patients? A critical appraisal of the evidence.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20081201

Title: Interference of drug-eluting stents with endothelium-dependent coronary vasomotion: evidence for device-specific responses.

Journal: Circulation. Cardiovascular interventions 20081201

Title: Long-term coronary endothelial function after zotarolimus-eluting stent implantation. A 9 month comparison between zotarolimus-eluting and sirolimus-eluting stents.

Journal: International heart journal 20081101

Title: Long-term safety and efficacy are observed after implantation of Zotarolimus-Eluting stent in real-world clinical practice.

Journal: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20081101

Title: Everolimus- and zotarolimus-eluting stents for bare metal stent in-stent restenosis treatment: a prospective study.

Journal: Journal of interventional cardiology 20081001

Title: A randomized, controlled, multicenter trial to evaluate the safety and efficacy of zotarolimus- versus paclitaxel-eluting stents in de novo occlusive lesions in coronary arteries The ZoMaxx I trial.

Journal: JACC. Cardiovascular interventions 20081001

Title: The process of bringing new drug-eluting stents to market will they see the light of day?

Journal: JACC. Cardiovascular interventions 20081001

Title: Angioscopic comparison of neointimal coverage between zotarolimus- and sirolimus-eluting stents.

Journal: Journal of the American College of Cardiology 20080826

Title: Coexistent in-stent restenosis, late incomplete stent apposition and mural thrombus in a zotarolimus-eluting stent.

Journal: The Journal of invasive cardiology 20080801

Title: Endothelial cell recovery between comparator polymer-based drug-eluting stents.

Journal: Journal of the American College of Cardiology 20080729

Title: Angiographic time course of in-stent restenosis with zotarolimus drug-eluting stents.

Journal: The Canadian journal of cardiology 20080701

Title: Development of a novel biocompatible polymer system for extended drug release in a next-generation drug-eluting stent.

Journal: Journal of biomedical materials research. Part A 20080615

Title: Overview of the 2007 Food and Drug Administration Circulatory System Devices Panel meeting on the endeavor zotarolimus-eluting coronary stent.

Journal: Circulation 20080325

Title: Successful percutaneous treatment of an intraprocedural left main stent thrombosis with the support of an automatic mechanical chest compression device.

Journal: International journal of cardiology 20080227

Title: Sirolimus, Tacrolimus and Zotarolimus eluting stents to treat bifurcated lesions: a 7-month clinical outcome comparison.

Journal: Minerva cardioangiologica 20080201

Title: Future stent drug delivery systems.

Journal: Minerva cardioangiologica 20080201

Title: Comparison of vascular response to zotarolimus-eluting stent versus sirolimus-eluting stent: intravascular ultrasound results from ENDEAVOR III.

Journal: American heart journal 20080101

Title: A preliminary experience report: Drug-eluting stents versus coronary artery bypass surgery in patients with a single lesion in the proximal left anterior descending artery suffering from diabetes mellitus and chronic stable angina.

Journal: Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20080101

Title: Meta-analysis shows similar risk of thrombosis after drug-eluting stent, bare-metal stent, or angioplasty.

Journal: Endothelium : journal of endothelial cell research 20080101

Title: Clinical results of drug eluting stents compared to bare metal stents for patients with ST elevation acute myocardial infarction.

Journal: Acute cardiac care 20080101

Title: Drug eluting stents versus coronary artery bypass surgery in patients with isolated proximal lesion in left anterior descending artery suffering from chronic stable angina.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20071115

Title: The significance of preclinical evaluation of sirolimus-, paclitaxel-, and zotarolimus-eluting stents.

Journal: The American journal of cardiology 20071022

Title: Zotarolimus-eluting stents in patients with native coronary artery disease: clinical and angiographic outcomes in 1,317 patients.

Journal: The American journal of cardiology 20071022

Title: Four-year clinical follow-up after implantation of the endeavor zotarolimus-eluting stent: ENDEAVOR I, the first-in-human study.

Journal: The American journal of cardiology 20071022

Title: The relation between clinical features, angiographic findings, and the target lesion revascularization rate in patients receiving the endeavor zotarolimus-eluting stent for treatment of native coronary artery disease: an analysis of ENDEAVOR I, ENDEAVOR II, ENDEAVOR II Continued Access Registry, and ENDEAVOR III.

Journal: The American journal of cardiology 20071022

Title: Intravascular ultrasound findings in ENDEAVOR II and ENDEAVOR III.

Journal: The American journal of cardiology 20071022

Title: Real-world safety and efficacy of the endeavor zotarolimus-eluting stent: early data from the E-Five Registry.

Journal: The American journal of cardiology 20071022

Title: Normal phase and reverse phase HPLC-UV-MS analysis of process impurities for rapamycin analog ABT-578: application to active pharmaceutical ingredient process development.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015

Title: Late vascular response at the edges of sirolimus analogous-eluting stents in diabetic patients: An intravascular ultrasound study.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20071001

Title: Determination of sirolimus in rabbit arteries using liquid chromatography separation and tandem mass spectrometric detection.

Journal: Biomedical chromatography : BMC 20071001

Title: The application of ink-jet technology for the coating and loading of drug-eluting stents.

Journal: Annals of biomedical engineering 20071001

Title: The pros and cons of living on the edge.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20071001

Title: A randomized comparison of sirolimus-eluting stent implantation with zotarolimus-eluting stent implantation for the treatment of total coronary occlusions: rationale and design of the PRImary Stenting of Occluded Native coronary arteries III (PRISON III) study.

Journal: American heart journal 20070901

Title: Detailed intravascular ultrasound analysis of Zotarolimus-eluting phosphorylcholine-coated cobalt-chromium alloy stent in de novo coronary lesions (results from the ENDEAVOR II trial).

Journal: The American journal of cardiology 20070901

Title: [Relationship between plasma C-reactive protein level and neointimal hyperplasia volume in patients with zotarolimus-eluting stents. Volumetric analysis by three-dimensional intracoronary ultrasound].

Journal: Revista espanola de cardiologia 20070901

Title: Clinical impact of in-stent late loss after drug-eluting coronary stent implantation.

Journal: European heart journal 20070701

Title: Modified T-stenting with intentional protrusion of the side-branch stent within the main vessel stent to ensure ostial coverage and facilitate final kissing balloon: the T-stenting and small protrusion technique (TAP-stenting). Report of bench testing and first clinical Italian-Korean two-centre experience.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20070701

Title: A three-dimensional intravascular ultrasound comparison between the new zotarolimus-eluting stent (ZoMaxx) and the non-drug-eluting TriMaxx stent.

Journal: The Journal of invasive cardiology 20070701

Title: Percutaneous coronary revascularization using a trilayer metal phosphorylcholine-coated zotarolimus-eluting stent.

Journal: The American journal of cardiology 20070515

Title: Accurate determination of an immunosuppressant in stented swine tissues with LC-MS/MS.

Journal: Analytical and bioanalytical chemistry 20070401

Title: Zotarolimus, a novel sirolimus analogue with potent anti-proliferative activity on coronary smooth muscle cells and reduced potential for systemic immunosuppression.

Journal: Journal of cardiovascular pharmacology 20070401

Title: Randomized, double-blind, multicenter study of the Endeavor zotarolimus-eluting phosphorylcholine-encapsulated stent for treatment of native coronary artery lesions. Clinical and angiographic results of the ENDEAVOR II Trial.

Journal: Minerva cardioangiologica 20070201

Title: TCT Daily: ZOMAXX I--mixed results with zotarolimus-eluting stent.

Journal: Journal of interventional cardiology 20070201

Title: Dilemma of drug-eluting stent implantation in a patient with systemic lupus erythematosus.

Journal: International journal of cardiology 20070118

Title: XIENCE V everolimus-eluting coronary stent system: a novel second generation drug-eluting stent.

Journal: Expert review of medical devices 20070101

Title: Do the benefits outweigh the risks with drug-eluting stents?

Journal: Scandinavian cardiovascular journal : SCJ 20070101

Title: Newer stents: looking at the horizon.

Journal: Indian heart journal 20070101

Title: Comparison of zotarolimus-eluting and sirolimus-eluting stents in patients with native coronary artery disease: a randomized controlled trial.

Journal: Journal of the American College of Cardiology 20061219

Title: Overview of pharmacology and clinical trials program with the zotarolimus-eluting endeavor stent.

Journal: Journal of interventional cardiology 20061001

Title: Randomized, double-blind, multicenter study of the Endeavor zotarolimus-eluting phosphorylcholine-encapsulated stent for treatment of native coronary artery lesions: clinical and angiographic results of the ENDEAVOR II trial.

Journal: Circulation 20060822

Title: Zotarolimus (ABT-578) eluting stents.

Journal: Advanced drug delivery reviews 20060603

Title: Zotarolimus-eluting stents reduce experimental coronary artery neointimal hyperplasia after 4 weeks.

Journal: European heart journal 20060401

Title: Method development and validation for zotarolimus concentration determination in stented swine arteries by liquid chromatography/tandem mass spectrometry detection.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: Subacute thrombosis following implantation of zotarolimus-eluting stent.

Journal: Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20060101

Title: Rapamycin analogs with reduced systemic exposure.

Journal: Bioorganic & medicinal chemistry letters 20051201

Title: Development and validation of a high-throughput assay for quantification of the proliferation inhibitor ABT-578 using LC/LC-MS/MS in blood and tissue samples.

Journal: Therapeutic drug monitoring 20051201

Title: Technology Insight: an overview of research in drug-eluting stents.

Journal: Nature clinical practice. Cardiovascular medicine 20051201

Title: A phase I multiple-dose escalation study characterizing pharmacokinetics and safety of ABT-578 in healthy subjects.

Journal: Journal of clinical pharmacology 20050801

Title: Stent-based delivery of ABT-578 via a phosphorylcholine surface coating reduces neointimal formation in the porcine coronary model.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20050601

Title: 96-Well liquid-liquid extraction liquid chromatography-tandem mass spectrometry method for the quantitative determination of ABT-578 in human blood samples.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040605

Title: ABT-578-eluting stents. The promising successor of sirolimus- and paclitaxel-eluting stent concepts?

Journal: Herz 20040301

Title: Method development for the quantitation of ABT-578 in rabbit artery tissue by 96-well liquid-liquid extraction and liquid chromatography/tandem mass spectrometric detection.

Journal: Rapid communications in mass spectrometry : RCM 20040101

Title: Sandra E Burke, et al. Zotarolimus (ABT-578) eluting stents. Adv Drug Deliv Rev. 2006 Jun 3;58(3):437-46.

Title: Zotarolimus, a novel sirolimus analogue with potent anti-proliferative activity on coronary smooth muscle cells and reduced potential for systemic immunosuppression.

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Tags:221877-54-9 Molecular Formula|221877-54-9 MDL|221877-54-9 SMILES|221877-54-9 Zotarolimus