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Home Other Building Blocks 1228105-51-8
1228105-51-8,MFCD28400099
Catalog No.:AA000JFV

1228105-51-8 | Maytansine, N2'-deacetyl-N2'-[3-[[1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]thio]-1-oxopropyl]-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$133.00   $93.00
- +
5mg
95%
in stock  
$307.00   $215.00
- +
10mg
95%
in stock  
$522.00   $365.00
- +
25mg
≥98%
in stock  
$1,302.00   $911.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000JFV
Chemical Name:
Maytansine, N2'-deacetyl-N2'-[3-[[1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]thio]-1-oxopropyl]-
CAS Number:
1228105-51-8
Molecular Formula:
C51H66ClN5O16S
Molecular Weight:
1072.6116
MDL Number:
MFCD28400099
SMILES:
CO[C@@H]1/C=C/C=C(\C)/Cc2cc(OC)c(c(c2)N(C(=O)C[C@@H]([C@]2([C@H]([C@@H]([C@@H]3C[C@@]1(O)NC(=O)O3)C)O2)C)OC(=O)[C@@H](N(C(=O)CCSC1CC(=O)N(C1=O)CC1CCC(CC1)C(=O)ON1C(=O)CCC1=O)C)C)C)Cl
Properties
Computed Properties
 
Complexity:
2250  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
74  
Hydrogen Bond Acceptor Count:
17  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
15  
Undefined Atom Stereocenter Count:
1  
XLogP3:
2.1  

Downstream Synthesis Route

[1]Patent:US2014/178413,2014,A1

[2]Patent:US2014/178415,2014,A1

Literature

Title: Shao S, et al. Site-specific and hydrophilic ADCs through disulfide-bridged linker and branched PEG. Bioorg Med Chem Lett. 2018 May 1;28(8):1363-1370.

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SDS
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Tags:1228105-51-8 Molecular Formula|1228105-51-8 MDL|1228105-51-8 SMILES|1228105-51-8 Maytansine, N2'-deacetyl-N2'-[3-[[1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]thio]-1-oxopropyl]-