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154947-66-7,MFCD09264694
Catalog No.:AA00AT8G

154947-66-7 | LL-37

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1mg
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  • Technical Information
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Technical Information
Catalog Number:
AA00AT8G
Chemical Name:
LL-37
CAS Number:
154947-66-7
Molecular Formula:
C207H341F3N60O55
Molecular Weight:
4607.2866
MDL Number:
MFCD09264694
SMILES:
OC(=O)C(F)(F)F.NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CO)CCC(=O)O)[C@H](O)C)CCCNC(=N)N)C(C)C)CC(C)C)CC(=O)N)CCCNC(=N)N)CC(C)C)Cc1ccccc1)CC(=O)O)CCCCN)[C@H](CC)C)CCCNC(=N)N)CCC(=O)N)C(C)C)[C@H](CC)C)CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]([C@H](CC)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)N)CC(C)C)CC(=O)O)Cc1ccccc1)Cc1ccccc1)CCCNC(=N)N)CCCCN)CO)CCCCN)CCC(=O)O)CCCCN)CCCCN)CCC(=O)O)Cc1ccccc1
Properties
Computed Properties
 
Complexity:
10700  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
39  
Heavy Atom Count:
318  
Hydrogen Bond Acceptor Count:
65  
Hydrogen Bond Donor Count:
68  
Rotatable Bond Count:
166  
XLogP3:
-20.7  

Literature

Title: Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids.

Journal: Molecular nutrition & food research 20140301

Title: The synthetic cathelicidin HHC-10 inhibits Mycobacterium bovis BCG in vitro and in C57BL/6 mice.

Journal: Microbial drug resistance (Larchmont, N.Y.) 20130401

Title: The antimicrobial peptide, LL-37, inhibits in vitro osteoclastogenesis.

Journal: Journal of dental research 20121101

Title: Cathepsin G-regulated release of formyl peptide receptor agonists modulate neutrophil effector functions.

Journal: The Journal of biological chemistry 20121005

Title: Induction of the human cathelicidin LL-37 as a novel treatment against bacterial infections.

Journal: Journal of leukocyte biology 20121001

Title: Autophagy induction by vitamin D inhibits both Mycobacterium tuberculosis and human immunodeficiency virus type 1.

Journal: Autophagy 20121001

Title: Synthesis, biological activity and conformational analysis of head-to-tail cyclic analogues of LL37 and histatin 5.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20120901

Title: Amphibian cathelicidin fills the evolutionary gap of cathelicidin in vertebrate.

Journal: Amino acids 20120801

Title: Anticancer peptide NK-2 targets cell surface sulphated glycans rather than sialic acids.

Journal: Biological chemistry 20120801

Title: Topical vitamin D₃ analogues induce thymic stromal lymphopoietin and cathelicidin in psoriatic skin lesions.

Journal: The British journal of dermatology 20120701

Title: Protective effects of cathelicidin-encoding Lactococcus lactis in murine ulcerative colitis.

Journal: Journal of gastroenterology and hepatology 20120701

Title: Salivary levels of antibacterial peptide (LL-37/hCAP-18) and cotinine in patients with chronic periodontitis.

Journal: Journal of periodontology 20120601

Title: The antimicrobial peptide LL-37 is anti-inflammatory and proapoptotic in human periodontal ligament cells.

Journal: Journal of periodontal research 20120601

Title: Decreased serum LL-37 and vitamin D3 levels in atopic dermatitis: relationship between IL-31 and oncostatin M.

Journal: Allergy 20120601

Title: Design of cyclic RKKH peptide-conjugated PEG liposomes targeting the integrin α₂β₁ receptor.

Journal: International journal of pharmaceutics 20120530

Title: PTH/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infection.

Journal: Science translational medicine 20120523

Title: Doxycycline indirectly inhibits proteolytic activation of tryptic kallikrein-related peptidases and activation of cathelicidin.

Journal: The Journal of investigative dermatology 20120501

Title: Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy.

Journal: PLoS pathogens 20120501

Title: Antimicrobial peptides in the pathogenesis of psoriasis.

Journal: The Journal of dermatology 20120301

Title: Recombinant production of cathelicidin-derived antimicrobial peptides in Escherichia coli using an inducible autocleaving enzyme tag.

Journal: New biotechnology 20120215

Title: Peptidylarginine deiminases present in the airways during tobacco smoking and inflammation can citrullinate the host defense peptide LL-37, resulting in altered activities.

Journal: American journal of respiratory cell and molecular biology 20120201

Title: Vitamin D and respiratory infection in adults.

Journal: The Proceedings of the Nutrition Society 20120201

Title: Design and characterization of novel hybrid antimicrobial peptides based on cecropin A, LL-37 and magainin II.

Journal: Peptides 20120201

Title: Msb2 shedding protects Candida albicans against antimicrobial peptides.

Journal: PLoS pathogens 20120201

Title: The cathelicidin-like peptide derived from panda genome is a potential antimicrobial peptide.

Journal: Gene 20120125

Title: Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor.

Journal: Oncogene 20120119

Title: Induction of triggering receptor expressed on myeloid cells (TREM-1) in airway epithelial cells by 1,25(OH)₂ vitamin D₃.

Journal: Innate immunity 20120101

Title: Vitamin D status and expression of vitamin D receptor and LL-37 in patients with spontaneous bacterial peritonitis.

Journal: Digestive diseases and sciences 20120101

Title: Antimicrobial and antibiofilm activity of LL-37 and its truncated variants against Burkholderia pseudomallei.

Journal: International journal of antimicrobial agents 20120101

Title: Cathelicidin LL-37 increases lung epithelial cell stiffness, decreases transepithelial permeability, and prevents epithelial invasion by Pseudomonas aeruginosa.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20111215

Title: Mutations in the ELANE gene are associated with development of periodontitis in patients with severe congenital neutropenia.

Journal: Journal of clinical immunology 20111201

Title: Recombinant production of antimicrobial peptides in Escherichia coli: a review.

Journal: Protein expression and purification 20111201

Title: A long-standing hyperglycaemic condition impairs skin barrier by accelerating skin ageing process.

Journal: Experimental dermatology 20111201

Title: Epidermal proteases in the pathogenesis of rosacea.

Journal: The journal of investigative dermatology. Symposium proceedings 20111201

Title: Expression of epidermal CAMP changes in parallel with permeability barrier status.

Journal: The Journal of investigative dermatology 20111101

Title: Signal transduction through CsrRS confers an invasive phenotype in group A Streptococcus.

Journal: PLoS pathogens 20111001

Title: Regulation of cathelicidin antimicrobial peptide expression by an endoplasmic reticulum (ER) stress signaling, vitamin D receptor-independent pathway.

Journal: The Journal of biological chemistry 20110930

Title: Stability of the cathelicidin peptide LL-37 in a non-healing wound environment.

Journal: Acta dermato-venereologica 20110901

Title: Antibacterial and anti-biofilm effects of cathelicidin peptides against pathogens isolated from cystic fibrosis patients.

Journal: Peptides 20110901

Title: Analytical platform for verification and quantitation of target peptides in human serum: application to cathelicidin.

Journal: Analytical biochemistry 20110801

Title: Wound healing activity of the human antimicrobial peptide LL37.

Journal: Peptides 20110701

Title: Involvement of P2X(7) purinergic receptor and MEK1/2 in interleukin-8 up-regulation by LL-37 in human gingival fibroblasts.

Journal: Journal of periodontal research 20110601

Title: Structure-activity studies and therapeutic potential of host defense peptides of human thrombin.

Journal: Antimicrobial agents and chemotherapy 20110601

Title: Hormonally active vitamin D3 (1alpha,25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection.

Journal: The Journal of biological chemistry 20110527

Title: Leukotriene B4/antimicrobial peptide LL-37 proinflammatory circuits are mediated by BLT1 and FPR2/ALX and are counterregulated by lipoxin A4 and resolvin E1.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110501

Title: A family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides.

Journal: PLoS pathogens 20110501

Title: TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes.

Journal: The Journal of investigative dermatology 20110301

Title: IL-1α stimulation restores epidermal permeability and antimicrobial barriers compromised by topical tacrolimus.

Journal: The Journal of investigative dermatology 20110301

Title: Restoring tacrolimus-induced impaired barrier function.

Journal: The Journal of investigative dermatology 20110301

Title: Human anti-microbial cathelicidin peptide LL-37 suppresses the LPS-induced apoptosis of endothelial cells.

Journal: International immunology 20110301

Title: Severe congenital neutropenia in a multigenerational family with a novel neutrophil elastase (ELANE) mutation.

Journal: Annals of hematology 20110201

Title: Analysis of the cathelicidin 1 gene locus in Atlantic cod (Gadus morhua).

Journal: Molecular immunology 20110201

Title: Autophagy negatively regulates keratinocyte inflammatory responses via scaffolding protein p62/SQSTM1.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20110115

Title: Low serum levels of cathelicidin LL-37 in leprosy.

Journal: Acta tropica 20110101

Title: Oligomeric structure of a cathelicidin antimicrobial peptide in dodecylphosphocholine micelle determined by NMR spectroscopy.

Journal: Biochimica et biophysica acta 20110101

Title: Cathelicidin LL-37 peptide regulates endothelial cell stiffness and endothelial barrier permeability.

Journal: American journal of physiology. Cell physiology 20110101

Title: The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis.

Journal: Journal of neuroinflammation 20110101

Title: Novel sulfated polysaccharides disrupt cathelicidins, inhibit RAGE and reduce cutaneous inflammation in a mouse model of rosacea.

Journal: PloS one 20110101

Title: Vitamin D, vitamin D receptor, and cathelicidin in the treatment of tuberculosis.

Journal: Vitamins and hormones 20110101

Title: The GBS PI-2a pilus is required for virulence in mice neonates.

Journal: PloS one 20110101

Title: IL-4 and IL-13 exposure during mucociliary differentiation of bronchial epithelial cells increases antimicrobial activity and expression of antimicrobial peptides.

Journal: Respiratory research 20110101

Title: Expression and activity of a novel cathelicidin from domestic cats.

Journal: PloS one 20110101

Title: Phenylbutyrate counteracts Shigella mediated downregulation of cathelicidin in rabbit lung and intestinal epithelia: a potential therapeutic strategy.

Journal: PloS one 20110101

Title: Lipopolysaccharide renders transgenic mice expressing human serum amyloid P component sensitive to Shiga toxin 2.

Journal: PloS one 20110101

Title: Successful in vitro expansion and differentiation of cord blood derived CD34+ cells into early endothelial progenitor cells reveals highly differential gene expression.

Journal: PloS one 20110101

Title: Evidence of an antimicrobial-immunomodulatory role of Atlantic salmon cathelicidins during infection with Yersinia ruckeri.

Journal: PloS one 20110101

Title: Ancient antimicrobial peptides kill antibiotic-resistant pathogens: Australian mammals provide new options.

Journal: PloS one 20110101

Title: Evaluation of the ability of LL-37 to neutralise LPS in vitro and ex vivo.

Journal: PloS one 20110101

Title: Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37.

Journal: PloS one 20110101

Title: LL37 and cationic peptides enhance TLR3 signaling by viral double-stranded RNAs.

Journal: PloS one 20110101

Title: Interdigitated electrodes based on impedance biosensor for sensing peptide LL-37.

Journal: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20110101

Title: T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20101228

Title: Dual functions of the human antimicrobial peptide LL-37-target membrane perturbation and host cell cargo delivery.

Journal: Biochimica et biophysica acta 20101201

Title: Increased serum leucine, leucine-37 levels in psoriasis: positive and negative feedback loops of leucine, leucine-37 and pro- or anti-inflammatory cytokines.

Journal: Human immunology 20101201

Title: PPARγ mediates innate immunity by regulating the 1α,25-dihydroxyvitamin D3 induced hBD-3 and cathelicidin in human keratinocytes.

Journal: Journal of dermatological science 20101201

Title: Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling.

Journal: Cellular microbiology 20101101

Title: Modulation of exogenous antibiotic activity by host cathelicidin LL-37.

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20101101

Title: Toll-like receptors and antimicrobial peptides expressions of psoriasis: correlation with serum vitamin D level.

Journal: Journal of Korean medical science 20101001

Title: Antibiotic-induced Porphyromonas gingivalis LPS release and inhibition of LPS-stimulated cytokines by antimicrobial peptides.

Journal: Peptides 20100901

Title: High level expression and purification of antimicrobial human cathelicidin LL-37 in Escherichia coli.

Journal: Applied microbiology and biotechnology 20100901

Title: Vitamin C attenuates ERK signalling to inhibit the regulation of collagen production by LL-37 in human dermal fibroblasts.

Journal: Experimental dermatology 20100801

Title: Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: past, present and future.

Journal: The Journal of steroid biochemistry and molecular biology 20100701

Title: A fowlicidin-1 analog protects mice from lethal infections induced by methicillin-resistant Staphylococcus aureus.

Journal: Peptides 20100701

Title: Topical calcineurin inhibitors compromise stratum corneum integrity, epidermal permeability and antimicrobial barrier function.

Journal: Experimental dermatology 20100601

Title: The antimicrobial peptide LL37 induces the migration of human pulp cells: a possible adjunct for regenerative endodontics.

Journal: Journal of endodontics 20100601

Title: Vitamin D and the immune system: new perspectives on an old theme.

Journal: Endocrinology and metabolism clinics of North America 20100601

Title: Battle and balance at mucosal surfaces--the story of Shigella and antimicrobial peptides.

Journal: Biochemical and biophysical research communications 20100521

Title: Injury downregulates the expression of the human cathelicidin protein hCAP18/LL-37 in atopic dermatitis.

Journal: Experimental dermatology 20100501

Title: Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid.

Journal: The Journal of investigative dermatology 20100501

Title: Novel cathelicidin-derived antimicrobial peptides from Equus asinus.

Journal: The FEBS journal 20100501

Title: Neuroendocrine nicotinic receptor activation increases susceptibility to bacterial infections by suppressing antimicrobial peptide production.

Journal: Cell host & microbe 20100422

Title: LL-37 via EGFR transactivation to promote high glucose-attenuated epithelial wound healing in organ-cultured corneas.

Journal: Investigative ophthalmology & visual science 20100401

Title: Topical treatment with the vitamin D analogue calcipotriol enhances the upregulation of the antimicrobial protein hCAP18/LL-37 during wounding in human skin in vivo.

Journal: Experimental dermatology 20100401

Title: Regulation by CRAMP of the responses of murine peritoneal macrophages to extracellular ATP.

Journal: Biochimica et biophysica acta 20100301

Title: Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Journal: Antimicrobial agents and chemotherapy 20100301

Title: Genome-wide transposon mutagenesis identifies a role for host neuroendocrine stress hormones in regulating the expression of virulence genes in Salmonella.

Journal: Journal of bacteriology 20100201

Title: Cholecalciferol supplementation alters calcitriol-responsive monocyte proteins and decreases inflammatory cytokines in ESRD.

Journal: Journal of the American Society of Nephrology : JASN 20100201

Title: Antimicrobial and membrane disrupting activities of a peptide derived from the human cathelicidin antimicrobial peptide LL37.

Journal: Biophysical journal 20100120

Title: High potency and broad-spectrum antimicrobial peptides synthesized via ring-opening polymerization of alpha-aminoacid-N-carboxyanhydrides.

Journal: Biomacromolecules 20100111

Title: Flagellin-induced corneal antimicrobial peptide production and wound repair involve a novel NF-kappaB-independent and EGFR-dependent pathway.

Journal: PloS one 20100101

Title: The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide.

Journal: PloS one 20100101

Title: Rosacea treatments: What's new and what's on the horizon?

Journal: American journal of clinical dermatology 20100101

Title: Safety and tolerability of a modified filter-type device for leukocytapheresis using ACD-A as anticoagulant in patients with mild to moderately active ulcerative colitis. Results of a pilot study.

Journal: Journal of clinical apheresis 20100101

Title: The human host defense peptide LL-37 interacts with Neisseria meningitidis capsular polysaccharides and inhibits inflammatory mediators release.

Journal: PloS one 20100101

Title: Generation of novel bone forming cells (monoosteophils) from the cathelicidin-derived peptide LL-37 treated monocytes.

Journal: PloS one 20100101

Title: ELISA for aging biomarkers induced by telomere dysfunction in human plasma.

Journal: Journal of biomedicine & biotechnology 20100101

Title: Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder.

Journal: PloS one 20100101

Title: Association of human cathelicidin (hCAP-18/LL-37) gene expression with cardiovascular disease risk factors.

Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD 20091201

Title: Fluorescence and UV resonance Raman study of peptide-vesicle interactions of human cathelicidin LL-37 and its F6W and F17W mutants.

Journal: Biochemistry 20091201

Title: Vitamin D(3) induces expression of human cathelicidin antimicrobial peptide 18 in newborns.

Journal: International journal of hematology 20091201

Title: [Rosacea 2009 : new advances in pathophysiology, clinical staging and therapeutic strategies].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20091201

Title: Neutrophil antimicrobial defense against Staphylococcus aureus is mediated by phagolysosomal but not extracellular trap-associated cathelicidin.

Journal: Journal of leukocyte biology 20091101

Title: Role of reactive oxygen species (ROS) in Mycobacterium bovis bacillus Calmette Guérin-mediated up-regulation of the human cathelicidin LL-37 in A549 cells.

Journal: Microbial pathogenesis 20091101

Title: Evidence that cathelicidin peptide LL-37 may act as a functional ligand for CXCR2 on human neutrophils.

Journal: European journal of immunology 20091101

Title: The vitamin D-antimicrobial peptide pathway and its role in protection against infection.

Journal: Future microbiology 20091101

Title: In vitro susceptibility of Burkholderia pseudomallei to antimicrobial peptides.

Journal: International journal of antimicrobial agents 20091001

Title: VDR and MEK-ERK dependent induction of the antimicrobial peptide cathelicidin in keratinocytes by lithocholic acid.

Journal: Molecular immunology 20091001

Title: Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin.

Journal: Cell host & microbe 20090917

Title: Bcl-3 acts as an innate immune modulator by controlling antimicrobial responses in keratinocytes.

Journal: The Journal of investigative dermatology 20090901

Title: Burkholderia cenocepacia zinc metalloproteases influence resistance to antimicrobial peptides.

Journal: Microbiology (Reading, England) 20090901

Title: Dysregulation of the vitamin D nuclear receptor may contribute to the higher prevalence of some autoimmune diseases in women.

Journal: Annals of the New York Academy of Sciences 20090901

Title: Intracellular receptor for human host defense peptide LL-37 in monocytes.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20090815

Title: Neutrophils launch monocyte extravasation by release of granule proteins.

Journal: Thrombosis and haemostasis 20090801

Title: Plasma 1,25 dihydroxy vitamin D3 level and expression of vitamin d receptor and cathelicidin in pulmonary tuberculosis.

Journal: Journal of clinical immunology 20090701

Title: Antimicrobial peptide-induced apoptotic death of leishmania results from calcium-de pend ent, caspase-independent mitochondrial toxicity.

Journal: The Journal of biological chemistry 20090605

Title: Leucine leucine-37 uses formyl peptide receptor-like 1 to activate signal transduction pathways, stimulate oncogenic gene expression, and enhance the invasiveness of ovarian cancer cells.

Journal: Molecular cancer research : MCR 20090601

Title: LL-37 inhibits serum amyloid A-induced IL-8 production in human neutrophils.

Journal: Experimental & molecular medicine 20090531

Title: A series of cationic sterol lipids with gene transfer and bactericidal activity.

Journal: Bioorganic & medicinal chemistry 20090501

Title: The human host defense peptide LL-37 induces apoptosis in a calpain- and apoptosis-inducing factor-dependent manner involving Bax activity.

Journal: Molecular cancer research : MCR 20090501

Title: Synthesis and anti-inflammatory properties of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3, a hypocalcemic, stable metabolite of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3.

Journal: Journal of medicinal chemistry 20090423

Title: The human antimicrobial peptide LL-37 suppresses apoptosis in keratinocytes.

Journal: The Journal of investigative dermatology 20090401

Title: Chicken heterophils are recruited to the site of Salmonella infection and release antibacterial mature Cathelicidin-2 upon stimulation with LPS.

Journal: Molecular immunology 20090401

Title: Bile salts control the antimicrobial peptide cathelicidin through nuclear receptors in the human biliary epithelium.

Journal: Gastroenterology 20090401

Title: Vitamin d-directed rheostatic regulation of monocyte antibacterial responses.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20090401

Title: Antimicrobial peptides and suppression of apoptosis in human skin.

Journal: The Journal of investigative dermatology 20090401

Title: NADPH oxidase 2 interaction with TLR2 is required for efficient innate immune responses to mycobacteria via cathelicidin expression.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20090315

Title: Identification and expression of a novel marsupial cathelicidin from the tammar wallaby (Macropus eugenii).

Journal: Veterinary immunology and immunopathology 20090215

Title: Recombinant adeno-associated virus-based gene transfer of cathelicidin induces therapeutic neovascularization preferentially via potent collateral growth.

Journal: Human gene therapy 20090201

Title: FPRL1-mediated induction of superoxide in LL-37-stimulated IMR90 human fibroblast.

Journal: Archives of biochemistry and biophysics 20090101

Title: Human antimicrobial protein hCAP18/LL-37 promotes a metastatic phenotype in breast cancer.

Journal: Breast cancer research : BCR 20090101

Title: Effects of an LL-37-derived antimicrobial peptide in an animal model of biofilm Pseudomonas sinusitis.

Journal: American journal of rhinology & allergy 20090101

Title: Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis.

Journal: Journal of translational medicine 20090101

Title: Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses.

Journal: PloS one 20090101

Title: Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates.

Journal: BMC genomics 20090101

Title: Vitamin D analogs differentially control antimicrobial peptide/'alarmin' expression in psoriasis.

Journal: PloS one 20090101

Title: Bactericidal activities of the cationic steroid CSA-13 and the cathelicidin peptide LL-37 against Helicobacter pylori in simulated gastric juice.

Journal: BMC microbiology 20090101

Title: Antimicrobial activity of human prion protein is mediated by its N-terminal region.

Journal: PloS one 20090101

Title: The effect of calcipotriol on the expression of human beta defensin-2 and LL-37 in cultured human keratinocytes.

Journal: Clinical & developmental immunology 20090101

Title: IL-17A enhances vitamin D3-induced expression of cathelicidin antimicrobial peptide in human keratinocytes.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20081215

Title: Biopositive effects of low-dose UVB on epidermis: coordinate upregulation of antimicrobial peptides and permeability barrier reinforcement.

Journal: The Journal of investigative dermatology 20081201

Title: Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles.

Journal: The Journal of biological chemistry 20081121

Title: Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20081115

Title: IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20081115

Title: Pimecrolimus enhances TLR2/6-induced expression of antimicrobial peptides in keratinocytes.

Journal: The Journal of investigative dermatology 20081101

Title: Vitamin D3 induces pro-LL-37 expression in myeloid precursors from patients with severe congenital neutropenia.

Journal: Journal of leukocyte biology 20081101

Title: Identification of a novel protein promoting the colonization and survival of Finegoldia magna, a bacterial commensal and opportunistic pathogen.

Journal: Molecular microbiology 20081101

Title: Glucosamine, a naturally occurring amino monosaccharide modulates LL-37-induced endothelial cell activation.

Journal: International journal of molecular medicine 20081101

Title: Efficacy of LL-37 and granulocyte colony-stimulating factor in a neutropenic murine sepsis due to Pseudomonas aeruginosa.

Journal: Shock (Augusta, Ga.) 20081001

Title: Oxidized phospholipids as potential molecular targets for antimicrobial peptides.

Journal: Biochimica et biophysica acta 20081001

Title: Cathelicidin administration protects mice from Bacillus anthracis spore challenge.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20081001

Title: Cathelicidin antimicrobial peptides inhibit hyaluronan-induced cytokine release and modulate chronic allergic dermatitis.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20080915

Title: Neutrophil secondary necrosis is induced by LL-37 derived from cathelicidin.

Journal: Journal of leukocyte biology 20080901

Title: Expression and secretion of cathelicidin LL-37 in human epithelial cells after infection by Mycobacterium bovis Bacillus Calmette-Guérin.

Journal: Clinical and vaccine immunology : CVI 20080901

Title: PU.1 and bacterial metabolites regulate the human gene CAMP encoding antimicrobial peptide LL-37 in colon epithelial cells.

Journal: Molecular immunology 20080901

Title: Neutrophil secretion products pave the way for inflammatory monocytes.

Journal: Blood 20080815

Title: Antimicrobial peptides and self-DNA in autoimmune skin inflammation.

Journal: Current opinion in immunology 20080801

Title: Did cathelicidins, a family of multifunctional host-defense peptides, arise from a cysteine protease inhibitor?

Journal: Trends in microbiology 20080801

Title: Sebocytes express functional cathelicidin antimicrobial peptides and can act to kill propionibacterium acnes.

Journal: The Journal of investigative dermatology 20080701

Title: Differential proteomic analysis of bovine conceptus fluid proteins in pregnancies generated by assisted reproductive technologies.

Journal: Proteomics 20080701

Title: Cholesterol, lanosterol, and ergosterol attenuate the membrane association of LL-37(W27F) and temporin L.

Journal: Biochimica et biophysica acta 20080601

Title: Increased resistance to cationic antimicrobial peptide LL-37 in methicillin-resistant strains of Staphylococcus aureus.

Journal: The Journal of antimicrobial chemotherapy 20080601

Title: NMR structure of the cathelicidin-derived human antimicrobial peptide LL-37 in dodecylphosphocholine micelles.

Journal: Biochemistry 20080520

Title: Activation of cathepsin L by the cathelin-like domain of protegrin-3.

Journal: Molecular immunology 20080501

Title: Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3.

Journal: The Journal of investigative dermatology 20080401

Title: Thermodynamics of the interactions of tryptophan-rich cathelicidin antimicrobial peptides with model and natural membranes.

Journal: Biochimica et biophysica acta 20080401

Title: Vitamin D regulation of cathelicidin in the skin: toward a renaissance of vitamin D in dermatology?

Journal: The Journal of investigative dermatology 20080401

Title: [Atopic dermatitis and stress? How do emotions come into skin?].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20080401

Title: Targeting the lipopolysaccharides: still a matter of debate?

Journal: Current opinion in anaesthesiology 20080401

Title: Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation.

Journal: Blood 20080315

Title: Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges.

Journal: The Journal of investigative dermatology 20080101

Title: In vitro and in vivo wound healing-promoting activities of human cathelicidin LL-37.

Journal: The Journal of investigative dermatology 20080101

Title: A colorimetric assay for studying effector secretion through the bacterial type III secretion system.

Journal: FEMS microbiology letters 20080101

Title: The epidermal vitamin D system and innate immunity: some more light shed on this unique photoendocrine system?

Journal: Dermatology (Basel, Switzerland) 20080101

Title: The GraRS regulatory system controls Staphylococcus aureus susceptibility to antimicrobial host defenses.

Journal: BMC microbiology 20080101

Title: Snake cathelicidin from Bungarus fasciatus is a potent peptide antibiotics.

Journal: PloS one 20080101

Title: SufA--a novel subtilisin-like serine proteinase of Finegoldia magna.

Journal: Microbiology (Reading, England) 20071201

Title: Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D(3).

Journal: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 20071101

Title: Interactions of tryptophan-rich cathelicidin antimicrobial peptides with model membranes studied by differential scanning calorimetry.

Journal: Biochimica et biophysica acta 20071001

Title: How lipids influence the mode of action of membrane-active peptides.

Journal: Biochimica et biophysica acta 20071001

Title: Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20070815

Title: Cathelicidin-derived Trp/Pro-rich antimicrobial peptides with lysine peptoid residue (Nlys): therapeutic index and plausible mode of action.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20070801

Title: Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea.

Journal: Nature medicine 20070801

Title: Rosacea: skin innate immunity gone awry?

Journal: Nature medicine 20070801

Title: Expression and modulation of progesterone induced blocking factor (PIBF) and innate immune factors in human leukemia cell lines by progesterone and mifepristone.

Journal: Leukemia & lymphoma 20070801

Title: Localization of hCAP-18 on the surface of chemoattractant-stimulated human granulocytes: analysis using two novel hCAP-18-specific monoclonal antibodies.

Journal: Journal of leukocyte biology 20070701

Title: The antimicrobial peptide LL-37 inhibits HIV-1 replication.

Journal: Current HIV research 20070701

Title: IFN-gamma- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20070601

Title: Impairment of innate immune killing mechanisms by bacteriostatic antibiotics.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070401

Title: Role of nuclear hormone receptors in butyrate-mediated up-regulation of the antimicrobial peptide cathelicidin in epithelial colorectal cells.

Journal: Molecular immunology 20070301

Title: Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism.

Journal: The Journal of clinical investigation 20070301

Title: Regulation of the CAMP gene by 1,25(OH)2D3 in various tissues.

Journal: The Journal of steroid biochemistry and molecular biology 20070301

Title: Antibacterial cathelicidin peptide CAP11 suppresses the anandamide production from lipopolysaccharide-stimulated mononuclear phagocytes.

Journal: FEBS letters 20070109

Title: Recombinant expression of human cathelicidin (hCAP18/LL-37) in Pichia pastoris.

Journal: Biotechnology letters 20070101

Title: Fungicidal activity of five cathelicidin peptides against clinically isolated yeasts.

Journal: The Journal of antimicrobial chemotherapy 20061101

Title: Different modes in antibiotic action of tritrpticin analogs, cathelicidin-derived Trp-rich and Pro/Arg-rich peptides.

Journal: Biochimica et biophysica acta 20061001

Title: Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20061001

Title: Pre-treatment of central venous catheters with the cathelicidin BMAP-28 enhances the efficacy of antistaphylococcal agents in the treatment of experimental catheter-related infection.

Journal: Peptides 20060901

Title: The cationic host defense peptide rCRAMP promotes gastric ulcer healing in rats.

Journal: The Journal of pharmacology and experimental therapeutics 20060801

Title: The cathelicidin-derived tritrpticin enhances the efficacy of ertapenem in experimental rat models of septic shock.

Journal: Shock (Augusta, Ga.) 20060801

Title: Control of the innate epithelial antimicrobial response is cell-type specific and dependent on relevant microenvironmental stimuli.

Journal: Immunology 20060801

Title: Copy number polymorphisms are not a common feature of innate immune genes.

Journal: Genomics 20060701

Title: Cloning, expression, isotope labeling, and purification of human antimicrobial peptide LL-37 in Escherichia coli for NMR studies.

Journal: Protein expression and purification 20060601

Title: Modulation by LL-37 of the responses of salivary glands to purinergic agonists.

Journal: Molecular pharmacology 20060601

Title: Heterogeneous expression of human cathelicidin hCAP18/LL-37 in inflammatory bowel diseases.

Journal: European journal of gastroenterology & hepatology 20060601

Title: Activation of human polymorphonuclear neutrophils by streptolysin O from Streptococcus pyogenes leads to the release of proinflammatory mediators.

Journal: Thrombosis and haemostasis 20060601

Title: The antimicrobial peptide LL-37 enhances IL-8 release by human airway smooth muscle cells.

Journal: The Journal of allergy and clinical immunology 20060601

Title: Structure-activity relationships of fowlicidin-1, a cathelicidin antimicrobial peptide in chicken.

Journal: The FEBS journal 20060601

Title: Sodium butyrate up-regulates cathelicidin gene expression via activator protein-1 and histone acetylation at the promoter region in a human lung epithelial cell line, EBC-1.

Journal: Molecular immunology 20060501

Title: Apoptosis of airway epithelial cells: human serum sensitive induction by the cathelicidin LL-37.

Journal: American journal of respiratory cell and molecular biology 20060401

Title: Fighting infections with vitamin D.

Journal: Nature medicine 20060401

Title: Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.

Journal: Science (New York, N.Y.) 20060324

Title: An antimicrobial cathelicidin peptide, human CAP18/LL-37, suppresses neutrophil apoptosis via the activation of formyl-peptide receptor-like 1 and P2X7.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20060301

Title: Mechanisms of cell death induced by the neutrophil antimicrobial peptides alpha-defensins and LL-37.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20060301

Title: Glycosaminoglycans inhibit the antibacterial activity of LL-37 in biological fluids.

Journal: The Journal of antimicrobial chemotherapy 20060201

Title: [Disturbances of antimicrobial lipids in atopic dermatitis].

Journal: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20060201

Title: Innate defences against methicillin-resistant Staphylococcus aureus (MRSA) infection.

Journal: The Journal of pathology 20060101

Title: Human cathelicidin LL-37 is a chemoattractant for eosinophils and neutrophils that acts via formyl-peptide receptors.

Journal: International archives of allergy and immunology 20060101

Title: The human cathelicidin peptide LL-37 and truncated variants induce segregation of lipids and proteins in the plasma membrane of Candida albicans.

Journal: Biological chemistry 20060101

Title: Human antimicrobial peptide LL-37 is present in atherosclerotic plaques and induces death of vascular smooth muscle cells: a laboratory study.

Journal: BMC cardiovascular disorders 20060101

Title: Human endogenous antibiotic LL-37 stimulates airway epithelial cell proliferation and wound closure.

Journal: American journal of physiology. Lung cellular and molecular physiology 20051101

Title: Vernix caseosa as a multi-component defence system based on polypeptides, lipids and their interactions.

Journal: Cellular and molecular life sciences : CMLS 20051001

Title: Antimicrobial peptides and endotoxin inhibit cytokine and nitric oxide release but amplify respiratory burst response in human and murine macrophages.

Journal: Cellular microbiology 20050901

Title: Human antimicrobial peptides: defensins, cathelicidins and histatins.

Journal: Biotechnology letters 20050901

Title: Expression and modulation of LL-37 in normal human keratinocytes, HaCaT cells, and inflammatory skin diseases.

Journal: Journal of Korean medical science 20050801

Title: Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050701

Title: Structure-function relationships among human cathelicidin peptides: dissociation of antimicrobial properties from host immunostimulatory activities.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20050401

Title: Augmentation of the bactericidal activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by amino acid substitutions.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050201

Title: Inhibition of early steps in the lentiviral replication cycle by cathelicidin host defense peptides.

Journal: Retrovirology 20050101

Title: Marked reduction of LL-37/hCAP-18, an antimicrobial peptide, in patients with acute myeloid leukemia.

Journal: International journal of hematology 20050101

Title: Antimicrobial peptides in human skin.

Journal: Chemical immunology and allergy 20050101

Title: Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20040901

Title: Histone-deacetylase inhibitors induce the cathelicidin LL-37 in gastrointestinal cells.

Journal: Molecular immunology 20040701

Title: A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20040415

Title: The interaction of streptococcal inhibitor of complement (SIC) and its proteolytic fragments with the human beta defensins.

Journal: Immunology 20040401

Title: The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20031215

Title: Cathelicidin family of antimicrobial peptides: proteolytic processing and protease resistance.

Journal: Bioorganic chemistry 20031201

Title: Effect of human cationic antimicrobial protein 18 Peptide on endotoxin-induced uveitis in rats.

Journal: Investigative ophthalmology & visual science 20031001

Title: Epithelial cell-derived antibacterial peptides human beta-defensins and cathelicidin: multifunctional activities on mast cells.

Journal: Current drug targets. Inflammation and allergy 20030901

Title: Processing of seminal plasma hCAP-18 to ALL-38 by gastricsin: a novel mechanism of generating antimicrobial peptides in vagina.

Journal: The Journal of biological chemistry 20030801

Title: Mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL-37.

Journal: Biochemistry 20030603

Title: An angiogenic role for the human peptide antibiotic LL-37/hCAP-18.

Journal: The Journal of clinical investigation 20030601

Title: Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways.

Journal: Gut 20030501

Title: Antimicrobial and protease inhibitory functions of the human cathelicidin (hCAP18/LL-37) prosequence.

Journal: The Journal of investigative dermatology 20030501

Title: In vitro effect on Cryptosporidium parvum of short-term exposure to cathelicidin peptides.

Journal: The Journal of antimicrobial chemotherapy 20030401

Title: Cathelicidins--a family of multifunctional antimicrobial peptides.

Journal: Cellular and molecular life sciences : CMLS 20030401

Title: Effects of human cathelicidin antimicrobial peptide LL-37 on lipopolysaccharide-induced nitric oxide release from rat aorta in vitro.

Journal: Acta anaesthesiologica Scandinavica 20030201

Title: Proteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL-37.

Journal: Molecular microbiology 20021001

Title: A cathelicidin family of human antibacterial peptide LL-37 induces mast cell chemotaxis.

Journal: Immunology 20020501

Title: Borrelia burgdorferi are susceptible to killing by a variety of human polymorphonuclear leukocyte components.

Journal: The Journal of infectious diseases 20020315

Title: Genetic and functional analysis of the phosphorylcholine moiety of commensal Neisseria lipopolysaccharide.

Journal: Molecular microbiology 20020101

Title: Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3.

Journal: Blood 20010615

Title: Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells.

Journal: European journal of immunology 20010401

Title: Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds.

Journal: Blood 20010101

Title: LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells.

Journal: The Journal of experimental medicine 20001002

Title: Structural features and biological activities of the cathelicidin-derived antimicrobial peptides.

Journal: Biopolymers 20000101

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Tags:154947-66-7 Molecular Formula|154947-66-7 MDL|154947-66-7 SMILES|154947-66-7 LL-37