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183658-72-2,MFCD06411598
Catalog No.:AA01ENE6

183658-72-2 | CYN 154806

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1mg
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  • Technical Information
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Technical Information
Catalog Number:
AA01ENE6
Chemical Name:
CYN 154806
CAS Number:
183658-72-2
Molecular Formula:
C56H68N12O14S2
Molecular Weight:
1197.3411
MDL Number:
MFCD06411598
SMILES:
NCCCC[C@@H]1NC(=O)[C@H](NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@@H](NC1=O)[C@H](O)C)C(=O)N[C@@H](C(=O)N)Cc1ccc(cc1)O)NC(=O)[C@H](Cc1ccc(cc1)[N+](=O)[O-])NC(=O)C)Cc1c[nH]c2c1cccc2
Properties
Computed Properties
 
Complexity:
2250  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Heavy Atom Count:
84  
Hydrogen Bond Acceptor Count:
17  
Hydrogen Bond Donor Count:
14  
Rotatable Bond Count:
19  
XLogP3:
2.1  

Literature

Title: Pasireotide (SOM230) protects the retina in animal models of ischemia induced retinopathies.

Journal: Experimental eye research 20121001

Title: The putative somatostatin antagonist cyclo-somatostatin has opioid agonist effects in gastrointestinal preparations.

Journal: Life sciences 20120522

Title: Somatostatin stimulates intestinal NHE8 expression via p38 MAPK pathway.

Journal: American journal of physiology. Cell physiology 20110201

Title: Expression, localization, and functional coupling of the somatostatin receptor subtype 2 in a mouse model of oxygen-induced retinopathy.

Journal: Investigative ophthalmology & visual science 20100401

Title: Activation of submucosal 5-HT(3) receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon.

Journal: British journal of pharmacology 20100401

Title: 5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20100301

Title: Activation of somatostatin receptor (sst 5) protects the rat retina from AMPA-induced neurotoxicity.

Journal: Neuropharmacology 20100101

Title: Effects of somatostatin analogues on retinal angiogenesis in a mouse model of oxygen-induced retinopathy: involvement of the somatostatin receptor subtype 2.

Journal: Investigative ophthalmology & visual science 20090801

Title: Involvement of prostacyclin/IP receptors in decreased acid response of damaged stomachs--mediation by somatostatin/SST2 receptors.

Journal: Life sciences 20090130

Title: Activation of somatostatin receptors in the globus pallidus increases rat locomotor activity and dopamine release in the striatum.

Journal: Psychopharmacology 20081201

Title: Somatostatin inhibits the excitability of rat small-diameter trigeminal ganglion neurons that innervate nasal mucosa and project to the upper cervical dorsal horn via activation of somatostatin 2a receptor.

Journal: Neuroscience 20070907

Title: Microinjection of exogenous somatostatin in the dorsal vagal complex inhibits pancreatic secretion via somatostatin receptor-2 in rats.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20070301

Title: Involvement of the somatostatin-2 receptor in the anti-convulsant effect of angiotensin IV against pilocarpine-induced limbic seizures in rats.

Journal: Journal of neurochemistry 20060801

Title: Somatostatin receptors in the ventral pallidum/substantia innominata modulate rat locomotor activity.

Journal: Psychopharmacology 20050901

Title: Somatostatin inhibits potassium-evoked glutamate release by activation of the sst(2) somatostatin receptor in the mouse retina.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030201

Title: Functional characterisation of the putative somatostatin sst2 receptor antagonist CYN 154806.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030101

Title: Inhibitory control of growth hormone secretion by somatostatin in rat pituitary GC cells: sst(2) but not sst(1) receptors are coupled to inhibition of single-cell intracellular free calcium concentrations.

Journal: Neuroendocrinology 20020801

Title: Somatostatin (SRIF) modulates distinct signaling pathways in rat pituitary tumor cells; negative coupling of SRIF receptor subtypes 1 and 2 to arachidonic acid release.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020301

Title: Bass RT, et al. Identification and characterization of novel somatostatin antagonists. Mol Pharmacol. 1996 Oct;50(4):709-15.

Title: Feniuk W, et al. Selective somatostatin sst(2) receptor blockade with the novel cyclic octapeptide, CYN-154806. Neuropharmacology. 2000 Jun 8;39(8):1443-50.

Title: Takeuchi K, et al. Activation of Muscarinic Acetylcholine Receptor Subtype 4 Is Essential for Cholinergic Stimulation of Gastric Acid Secretion: Relation to D Cell/Somatostatin. Front Pharmacol. 2016 Aug 30;7:278.

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Tags:183658-72-2 Molecular Formula|183658-72-2 MDL|183658-72-2 SMILES|183658-72-2 CYN 154806