Title: Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues.
Journal: Bioorganic & medicinal chemistry 20131101
Title: A mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent models.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20121201
Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Journal: PLoS computational biology 20111201
Title: Mechanisms underlying differences in systemic exposure of structurally similar active metabolites: comparison of two preclinical hepatic models.
Journal: The Journal of pharmacology and experimental therapeutics 20110501
Title: Combined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivo.
Journal: PloS one 20110101
Title: Diamidines for human African trypanosomiasis.
Journal: Current opinion in investigational drugs (London, England : 2000) 20100801
Title: Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles.
Journal: Bioorganic & medicinal chemistry 20100515
Title: Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles.
Journal: Journal of medicinal chemistry 20100114
Title: Application of monoclonal antibodies to measure metabolism of an anti-trypanosomal compound in vitro and in vivo.
Journal: Journal of clinical laboratory analysis 20100101
Title: Phase I/II evaluation of the prophylactic antimalarial activity of pafuramidine in healthy volunteers challenged with Plasmodium falciparum sporozoites.
Journal: The American journal of tropical medicine and hygiene 20090401
Title: Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis.
Journal: Acta tropica 20081001
Title: Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines.
Journal: Bioorganic & medicinal chemistry 20080115
Title: Carbamate prodrugs of N-alkylfuramidines.
Journal: European journal of medicinal chemistry 20080101
Title: Pafuramidine for Pneumocystis jiroveci pneumonia in HIV-infected individuals.
Journal: Expert review of anti-infective therapy 20071201
Title: Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20071101
Title: Pharmacokinetics and metabolism of the prodrug DB289 (2,5-bis[4-(N-methoxyamidino)phenyl]furan monomaleate) in rat and monkey and its conversion to the antiprotozoal/antifungal drug DB75 (2,5-bis(4-guanylphenyl)furan dihydrochloride).
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070601
Title: CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime].
Journal: Drug metabolism and disposition: the biological fate of chemicals 20061201
Title: Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues.
Journal: Journal of medicinal chemistry 20060824
Title: Diamidines as antitrypanosomal, antileishmanial and antimalarial agents.
Journal: Current opinion in investigational drugs (London, England : 2000) 20060201
Title: Unusual dehydroxylation of antimicrobial amidoxime prodrugs by cytochrome b5 and NADH cytochrome b5 reductase.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20051201
Title: Efficacy of DB289 in Thai patients with Plasmodium vivax or acute, uncomplicated Plasmodium falciparum infections.
Journal: The Journal of infectious diseases 20050715
Title: Treatment and control of human African trypanosomiasis.
Journal: Current opinion in infectious diseases 20041201
Title: O-alkoxyamidine prodrugs of furamidine: in vitro transport and microsomal metabolism as indicators of in vivo efficacy in a mouse model of Trypanosoma brucei rhodesiense infection.
Journal: Journal of medicinal chemistry 20040812
Title: Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents.
Journal: Journal of medicinal chemistry 20040701
Title: Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue.
Journal: Acta tropica 20040701
Title: Metabolites of an orally active antimicrobial prodrug, 2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime, identified by liquid chromatography/tandem mass spectrometry.
Journal: Journal of mass spectrometry : JMS 20040401
Title: DB-289 Immtech International.
Journal: IDrugs : the investigational drugs journal 20031101
Title: New oral drug for PCP.
Journal: AIDS patient care and STDs 20031101
Title: Synthesis and antiprotozoal activity of aza-analogues of furamidine.
Journal: Journal of medicinal chemistry 20031023
Title: Detection of inhibition of bovine viral diarrhea virus by aromatic cationic molecules.
Journal: Antimicrobial agents and chemotherapy 20030701
Title: Enhanced permeability of the antimicrobial agent 2,5-bis(4-amidinophenyl)furan across Caco-2 cell monolayers via its methylamidoidme prodrug.
Journal: Pharmaceutical research 20021101
Title: Treatment of human African trypanosomiasis--present situation and needs for research and development.
Journal: The Lancet. Infectious diseases 20020701
Title: Characterizing the fragmentation of 2,5-bis (4-amidinophenyl)furan-bis-O-methylamidoxime and selected metabolites using ion trap mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM 20020101
Title: Lanteri CA, Trumpower BL, Tidwell RR, DB75, a novel trypanocidal agent, disrupts mitochondrial function in Saccharomyces cerevisiae. Antimicrob Agents Chemother. 2004 Oct;48(10):3968-74.
Title: Midgley I, Fitzpatrick K, Taylor LM, Pharmacokinetics and metabolism of the prodrug DB289 (2,5-bis-(N-methoxyamidino)phenylfuran monomaleate) in rat and monkey and its conversion to the antiprotozoal/antifungal drug DB75 (2,5-bis(4-guanylphenyl)furan dihydrochloride). Drug Metab Dispos. 2007 Jun;35(6):955-67.
Title: Sturk LM, Brock JL, Bagnell CR, Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue. Acta Trop. 2004 Jul;91(2):131-43.
Title: In vitro inhibitory activity against Trypanosoma brucei rhodesiense - BioAssay Summary.
