Home Fluorides 457639-26-8
457639-26-8,MFCD19443858
Catalog No.:AA00DF96

457639-26-8 | 4-(5-(2,5-Dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

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5mg
≥95%
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$70.00   $49.00
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10mg
≥95%
in stock  
$132.00   $92.00
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25mg
≥95%
in stock  
$256.00   $179.00
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50mg
100%
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DF96
Chemical Name:
4-(5-(2,5-Dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
CAS Number:
457639-26-8
Molecular Formula:
C18H16F3N3O2S
Molecular Weight:
395.3987
MDL Number:
MFCD19443858
SMILES:
Cc1ccc(c(c1)c1cc(nn1c1ccc(cc1)S(=O)(=O)N)C(F)(F)F)C
Properties
Computed Properties
 
Complexity:
614  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
3.8  

Literature

Title: Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors.

Journal: Cancer letters 20121201

Title: Predicting new indications for approved drugs using a proteochemometric method.

Journal: Journal of medicinal chemistry 20120809

Title: Characteristics and molecular basis of celecoxib modulation on K(v)7 potassium channels.

Journal: British journal of pharmacology 20111101

Title: Celecoxib and 2,5-dimethyl-celecoxib prevent cardiac remodeling inhibiting Akt-mediated signal transduction in an inherited dilated cardiomyopathy mouse model.

Journal: The Journal of pharmacology and experimental therapeutics 20110701

Title: Enhancement of photodynamic therapy by 2,5-dimethyl celecoxib, a non-cyclooxygenase-2 inhibitor analog of celecoxib.

Journal: Cancer letters 20110501

Title: Dimethylcelecoxib inhibits mPGES-1 promoter activity by influencing EGR1 and NF-κB.

Journal: Biochemical pharmacology 20101101

Title: Antiangiogenic activities of 2,5-dimethyl-celecoxib on the tumor vasculature.

Journal: Molecular cancer therapeutics 20100301

Title: Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress.

Journal: Cancer letters 20090908

Title: Dimethylcelecoxib inhibits prostaglandin E2 production.

Journal: Biochemical pharmacology 20080701

Title: Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs.

Journal: Expert opinion on investigational drugs 20080201

Title: Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib.

Journal: Cancer research 20080201

Title: COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro.

Journal: Molecular cancer 20080101

Title: CCAAT/enhancer binding protein homologous protein-dependent death receptor 5 induction and ubiquitin/proteasome-mediated cellular FLICE-inhibitory protein down-regulation contribute to enhancement of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by dimethyl-celecoxib in human non small-cell lung cancer cells.

Journal: Molecular pharmacology 20071101

Title: Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib.

Journal: Molecular cancer therapeutics 20070401

Title: Antitumor properties of dimethyl-celecoxib, a derivative of celecoxib that does not inhibit cyclooxygenase-2: implications for glioma therapy.

Journal: Neurosurgical focus 20060415

Title: Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo.

Journal: Molecular cancer 20060101

Title: Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib.

Journal: Blood 20051215

Title: Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo.

Journal: Cancer biology & therapy 20050501

Title: DMC: novel celecoxib derivatives to rap cancer.

Journal: Cancer biology & therapy 20050501

Title: Growth inhibitory effects of celecoxib in human umbilical vein endothelial cells are mediated through G1 arrest via multiple signaling mechanisms.

Journal: Molecular cancer therapeutics 20041201

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SDS
Tags:457639-26-8 Molecular Formula|457639-26-8 MDL|457639-26-8 SMILES|457639-26-8 4-(5-(2,5-Dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide