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Home Other Building Blocks 500992-11-0
500992-11-0,MFCD09842404
Catalog No.:AA00DB8H

500992-11-0 | Tat-NR2B9c

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
1 week  
$131.00   $92.00
- +
5mg
95%
1 week  
$243.00   $170.00
- +
  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DB8H
Chemical Name:
Tat-NR2B9c
CAS Number:
500992-11-0
Molecular Formula:
C105H188N42O30
Molecular Weight:
2518.8796
MDL Number:
MFCD09842404
SMILES:
NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)C(C)C)CC(=O)O)CO)CCC(=O)O)[C@H](CC)C)CO)CO)CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc1ccc(cc1)O)N)CCCNC(=N)N)CCCCN)CCCCN)CCCNC(=N)N)CCCNC(=N)N)CCC(=O)N)CCCNC(=N)N)CCCNC(=N)N)CCCNC(=N)N
Properties
Computed Properties
 
Complexity:
5380  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
177  
Hydrogen Bond Acceptor Count:
40  
Hydrogen Bond Donor Count:
49  
Rotatable Bond Count:
99  
Undefined Atom Stereocenter Count:
20  
XLogP3:
-19.3  

Literature

Title: Cui H, et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci. 2007 Sep 12;27(37):9901-15.

Title: Fan J, et al. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease. Neurobiol Dis. 2012 Mar;45(3):999-1009.

Title: Teves LM, et al. Efficacy of the PSD95 inhibitor Tat-NR2B9c in mice requires dose translation between species. J Cereb Blood Flow Metab. 2016 Mar;36(3):555-61.

Title: Jing Fan, et al. N-methyl-D-aspartate Receptor Subunit- And Neuronal-Type Dependence of Excitotoxic Signaling Through Post-Synaptic Density 9. J Neurochem. 2010 Nov;115(4):1045-56.

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SDS
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Tags:500992-11-0 Molecular Formula|500992-11-0 MDL|500992-11-0 SMILES|500992-11-0 Tat-NR2B9c