Catalog No.:AA00DENZ

53350-26-8 | 5,7-Dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one

Name: Name:5,7-Dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one
Brand: AABLOCKS
SKU: AA00DENZ
Availability: InStock
Rating: 90 (10 reviews)

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Price(USD)

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5mg

99%

1 week

$304.00 $213.00

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10mg

99%

1 week

$479.00 $335.00

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Technical Information
Properties
Upstream Synthesis Route
Literature
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Technical Information
Properties
Upstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA00DENZ

Chemical Name:

5,7-Dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one

CAS Number:

53350-26-8

Molecular Formula:

C20H20O7

Molecular Weight:

372.3686

MDL Number:

MFCD00017634

SMILES:

COc1cc(OC)c2c(c1)oc(cc2=O)c1cc(OC)c(c(c1)OC)OC

Properties

BP:

554.4°C at 760 mmHg

Form:

Solid

MP:

193-195°C

Storage:

Keep in dry area;2-8℃;

Computed Properties

Complexity:

534

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Rotatable Bond Count:

XLogP3:

Upstream Synthesis Route

84212-57-7

53350-26-8

[1]JournalofChemicalResearch,Miniprint,1982,#9,p.2461-2487

[2]JournalofScientificandIndustrialResearch,1955,vol.14B,p.6,10

[3]Molecules,2014,vol.19,#7,p.8933-8948

[4]Patent:US2015/196529,2015,A1,.Locationinpatent:Paragraph0223;0226

[5]Patent:US9669003,2017,B2,.Locationinpatent:Page/Pagecolumn48;49;50

53350-27-9

53350-26-8

[1]Synthesis(Germany),2018,vol.50,#8,p.1610-1620

392302-51-1

53350-26-8

[1]TetrahedronLetters,2001,vol.42,#50,p.8907-8909

90-24-4

4521-61-3

53350-26-8

[1]JournalofHeterocyclicChemistry,2002,vol.39,#6,p.1251-1258

480-66-0

53350-26-8

[1]JournalofHeterocyclicChemistry,2002,vol.39,#6,p.1251-1258

[2]CanadianJournalofResearch,1932,vol.7,p.285,289

[3]CanadianJournalofResearch,1932,vol.7,p.285,289

[4]Synthesis(Germany),2018,vol.50,#8,p.1610-1620

Literature

Title: Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone).

Journal: Cancer chemotherapy and pharmacology 20110201

Title: [Isolation and purification of flavones from Murraya exotica L. by high-speed counter-current chromatography].

Journal: Se pu = Chinese journal of chromatography 20100401

Title: APC10.1 cells as a model for assessing the efficacy of potential chemopreventive agents in the Apc(Min) mouse model in vivo.

Journal: European journal of cancer (Oxford, England : 1990) 20091101

Title: Flavones as colorectal cancer chemopreventive agents--phenol-o-methylation enhances efficacy.

Journal: Cancer prevention research (Philadelphia, Pa.) 20090801

Title: Determination of 3',4',5',5,7-pentamethoxyflavone in the plasma and intestinal mucosa of mice by HPLC with UV detection.

Journal: Biomedical chromatography : BMC 20090401

Title: Reversal of P-glycoprotein-mediated MDR by 5,7,3',4',5'-pentamethoxyflavone and SAR.

Journal: Biochemical and biophysical research communications 20040730

Title: Chalcones and flavonoids as anti-tuberculosis agents.

Journal: Bioorganic & medicinal chemistry 20020801

Title: Hou X, et al. 3',4',5',5,7-pentamethoxyflavone sensitizes Cisplatin-resistant A549 cells to Cisplatin by inhibition of Nrf2 pathway. Mol Cells. 2015 May;38(5):396-401.

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