Home Fluorides 5593-20-4
5593-20-4,MFCD00072035
Catalog No.:AA00I9WN

5593-20-4 | Pregna-1,4-diene-3,20-dione,9-fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11b,16b)-

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250mg
95%
in stock  
$70.00   $49.00
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1g
95%
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$207.00   $145.00
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5g
95%
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$864.00   $605.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I9WN
Chemical Name:
Pregna-1,4-diene-3,20-dione,9-fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11b,16b)-
CAS Number:
5593-20-4
Molecular Formula:
C28H37FO7
Molecular Weight:
504.5876
MDL Number:
MFCD00072035
SMILES:
CCC(=O)OC1(C(C)CC2C1(C)CC(O)C1(C2CCC2=CC(=O)C=CC12C)F)C(=O)COC(=O)CC
Properties
Computed Properties
 
Complexity:
1050  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
XLogP3:
3.6  

Literature

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Title: Exclusive plaque psoriasis of the lips: efficacy of combination therapy of topical tacrolimus, calcipotriol, and betamethasone dipropionate.

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Title: Spotlight on calcipotriene/betamethasone dipropionate in psoriasis vulgaris of the trunk, limbs, and scalp.

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Title: Once-daily application of calcipotriene 0.005%-betamethasone dipropionate 0.064% ointment for repigmentation of facial vitiligo.

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Title: Efficacy and safety of adalimumab in patients with psoriasis previously treated with anti-tumour necrosis factor agents: subanalysis of BELIEVE.

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Title: Evaluating the efficacy and safety of calcipotriene/betamethasone ointment occluded with a hydrogel patch: a 6-week bilaterally controlled, investigator-blinded trial.

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Title: Irreversible visual loss secondary to excessive topical steroid use in eczema.

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Title: The separate daily application of tacalcitol 4 µg/g ointment and budesonide 0.25 mg/g cream is more effective than the single daily application of a two compound ointment containing calcipotriol 50 µg/g and betamethasone dipropionate 0.5 mg/g.

Journal: Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 20110801

Title: Topical calcipotriene 0.005% and betamethasone dipropionate 0.064% maintains efficacy of etanercept after step-down dose in patients with moderate-to-severe plaque psoriasis: results of an open label trial.

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Title: Circulating Th17 cell fluctuation in psoriatic patients treated with topical calcipotriol and betamethasone butyrate propionate.

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Title: Significant one week efficacy of a calcipotriol plus betamethasone dipropionate scalp formulation.

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Title: Pharmacokinetics of betamethasone and betamethasone 17-monopropionate in Chinese healthy volunteers after intramuscular injection of betamethasone phosphate/betamethasone dipropionate.

Journal: Arzneimittel-Forschung 20110101

Title: Needle-knife incisional treatment of refractory esophagic caustic stenosis.

Journal: Endoscopy 20110101

Title: Archaeosomes as carriers for topical delivery of betamethasone dipropionate: in vitro skin permeation study.

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Journal: Nanomedicine (London, England) 20101101

Title: Development and validation of a stability-indicating RP-HPLC method for simultaneous assay of betamethasone dipropionate, chlorocresol, and for the estimation of betamethasone dipropionate related compounds in a pharmaceutical cream and ointment.

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Title: Topical steroid is effective for the treatment of phimosis in young children.

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Title: Rapid structure elucidation of drug degradation products using mechanism-based stress studies in conjunction with LC-MS(n) and NMR spectroscopy: identification of a photodegradation product of betamethasone dipropionate.

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Title: Development and validation of a stability-indicating HPLC method for simultaneous determination of salicylic acid, betamethasone dipropionate and their related compounds in Diprosalic Lotion.

Journal: Journal of pharmaceutical and biomedical analysis 20091015

Title: Linear IgA bullous dermatosis of childhood: successful treatment with miocamycin and topical corticosteroid.

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Title: Efficacy and safety of calcipotriol plus betamethasone dipropionate scalp formulation compared with calcipotriol scalp solution in the treatment of scalp psoriasis: a randomized controlled trial.

Journal: The British journal of dermatology 20090701

Title: Comparison of ultrasound-, palpation-, and scintigraphy-guided steroid injections in the treatment of plantar fasciitis.

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Title: A new scalp formulation of calcipotriol plus betamethasone dipropionate compared with each of its active ingredients in the same vehicle for the treatment of scalp psoriasis: a randomized, double-blind, controlled trial.

Journal: The British journal of dermatology 20090101

Title: Comparing clobetasol propionate 0.05% spray to calcipotriene 0.005% betamethasone dipropionate 0.064% ointment for the treatment of moderate to severe plaque psoriasis.

Journal: Journal of drugs in dermatology : JDD 20090101

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Title: A study of the safety and efficacy of calcipotriol and betamethasone dipropionate scalp formulation in the long-term management of scalp psoriasis.

Journal: Dermatology (Basel, Switzerland) 20081101

Title: Hyperkeratosis lenticularis perstans (Flegel's disease) - successful treatment with topical corticosteroids.

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Title: A new scalp formulation of calcipotriene plus betamethasone compared with its active ingredients and the vehicle in the treatment of scalp psoriasis: a randomized, double-blind, controlled trial.

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Title: Cost-effectiveness of the two-compound formulation calcipotriol and betamethasone dipropionate compared with commonly used topical treatments in the management of moderately severe plaque psoriasis in Scotland.

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Title: Pulsed dye laser versus treatment with calcipotriol/betamethasone dipropionate for localized refractory plaque psoriasis: effects on T-cell infiltration, epidermal proliferation and keratinization.

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Journal: The British journal of dermatology 20060601

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Journal: Expert opinion on pharmacotherapy 20060401

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Journal: Gaceta medica de Mexico 20060101

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Journal: Dermatology (Basel, Switzerland) 20060101

Title: Efficacy results of a 52-week, randomised, double-blind, safety study of a calcipotriol/betamethasone dipropionate two-compound product (Daivobet/Dovobet/Taclonex) in the treatment of psoriasis vulgaris.

Journal: Dermatology (Basel, Switzerland) 20060101

Title: Treatment of psoriasis vulgaris with the two-compound product calcipotriol/betamethasone dipropionate followed by different formulations of calcipotriol.

Journal: Clinical drug investigation 20060101

Title: Once daily vs. twice daily applications of topical treatments in psoriasis.

Journal: The British journal of dermatology 20051201

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Journal: Revue medicale de Liege 20051101

Title: [Leg ulcers: peri-ulcerous dermatitis].

Journal: Soins; la revue de reference infirmiere 20050901

Title: A group III steroid solution without antibiotic components: an effective cure for external otitis.

Journal: The Journal of laryngology and otology 20050501

Title: Death by oral ingestion of iodine.

Journal: Emergency medicine Australasia : EMA 20050401

Title: External otitis caused by infection with Pseudomonas aeruginosa or Candida albicans cured by use of a topical group III steroid, without any antibiotics.

Journal: Acta oto-laryngologica 20050401

Title: Intralesional steroid injection for management of acute idiopathic dacryoadenitis: a preliminary result.

Journal: Ophthalmic plastic and reconstructive surgery 20050301

Title: Ultrapotent topical corticosteroid treatment of hemangiomas of infancy.

Journal: Journal of the American Academy of Dermatology 20050201

Title: Lumbar zygapophyseal joint injections in patients with chronic lower back pain.

Journal: Journal of the Chinese Medical Association : JCMA 20050201

Title: Efficacy and local safety of a calcipotriol/ betamethasone dipropionate ointment in elderly patients with psoriasis vulgaris.

Journal: European journal of dermatology : EJD 20050101

Title: A two-compound product containing calcipotriol and betamethasone dipropionate provides rapid, effective treatment of psoriasis vulgaris regardless of baseline disease severity.

Journal: Dermatology (Basel, Switzerland) 20050101

Title: Cost-effectiveness of once-daily treatment with calcipotriol/betamethasone dipropionate followed by calcipotriol alone compared with tacalcitol in the treatment of Psoriasis vulgaris.

Journal: Dermatology (Basel, Switzerland) 20050101

Title: Treatment of guttate psoriasis with a new two-compound product containing calcipotriol and betamethasone dipropionate.

Journal: International journal of clinical pharmacology research 20050101

Title: Glaucoma induced by periorbital topical steroid use--a rare complication.

Journal: Clinical and experimental dermatology 20041101

Title: The impact of a two-compound product containing calcipotriol and betamethasone dipropionate (Daivobet/ Dovobet) on the quality of life in patients with psoriasis vulgaris: a randomized controlled trial.

Journal: The British journal of dermatology 20040901

Title: [How I treat ...scalp psoriasis].

Journal: Revue medicale de Liege 20040901

Title: Bioavailability of betamethasone dipropionate when combined with calcipotriol.

Journal: International journal of dermatology 20040801

Title: Intermittent topical corticosteroid/tacrolimus sequential therapy improves lichenification and chronic papules more efficiently than intermittent topical corticosteroid/emollient sequential therapy in patients with atopic dermatitis.

Journal: The Journal of dermatology 20040701

Title: Efficacy of once-daily treatment regimens with calcipotriol/betamethasone dipropionate ointment and calcipotriol ointment in psoriasis vulgaris.

Journal: The British journal of dermatology 20040601

Title: Glaucoma from topical corticosteroids to the eyelids.

Journal: Clinical & experimental ophthalmology 20040401

Title: [Corticoid therapy in asthma. Smaller particles--bigger effect].

Journal: MMW Fortschritte der Medizin 20040325

Title: Analysis of factors associated with prescription of a potentially inappropriate combination dermatological medication among US outpatient physicians.

Journal: Pharmacoepidemiology and drug safety 20040301

Title: Topical corticosteroid allergy in an urban Australian centre.

Journal: Contact dermatitis 20040101

Title: Fixed-dose combination therapy for psoriasis.

Journal: American journal of clinical dermatology 20040101

Title: [Our experience using triderm for the treatment of external otitis].

Journal: Vestnik otorinolaringologii 20040101

Title: Efficacy of treatment with calcipotriol/betamethasone dipropionate followed by calcipotriol alone compared with tacalcitol for the treatment of psoriasis vulgaris: a randomised, double-blind trial.

Journal: Dermatology (Basel, Switzerland) 20040101

Title: Generalized pustular psoriasis (von Zumbusch) following iatrogenic hypocortisolism.

Journal: European journal of dermatology : EJD 20040101

Title: Development of a new formulation combining calcipotriol and betamethasone dipropionate in an ointment vehicle.

Journal: Drug development and industrial pharmacy 20040101

Title: Calcipotriol/betamethasone dipropionate: a review of its use in the treatment of psoriasis vulgaris.

Journal: American journal of clinical dermatology 20040101

Title: Efficacy of betamethasone valerate foam formulation in comparison with betamethasone dipropionate lotion in the treatment of mild-to-moderate alopecia areata: a multicenter, prospective, randomized, controlled, investigator-blinded trial.

Journal: International journal of dermatology 20030701

Title: Adrenal insufficiency and diabetes mellitus secondary to the use of topical corticosteroids for cosmetic purpose.

Journal: Annales d'endocrinologie 20030601

Title: O'Brien's actinic granuloma in association with prolonged doxycycline phototoxicity.

Journal: The Australasian journal of dermatology 20030201

Title: [New ointment with vitamin D derivative and corticoid. Psoriasis therapy combined].

Journal: MMW Fortschritte der Medizin 20030130

Title: Persistent and recurrent tinea corporis in children treated with combination antifungal/ corticosteroid agents.

Journal: Pediatrics 20030101

Title: Early onset of action and efficacy of a combination of calcipotriene and betamethasone dipropionate in the treatment of psoriasis.

Journal: Journal of the American Academy of Dermatology 20030101

Title: Intertriginous granular parakeratosis responsive to potent topical corticosteroids.

Journal: Clinical and experimental dermatology 20030101

Title: Calcitriol shows greater persistence of treatment effect than betamethasone dipropionate in topical psoriasis therapy.

Journal: The Journal of dermatological treatment 20030101

Title: The atrophogenic potential and dermal tolerance of calcipotriol/betamethasone dipropionate ointment compared with betamethasone dipropionate ointment.

Journal: Dermatology (Basel, Switzerland) 20030101

Title: Once daily application of a combination of calcipotriol and betamethasone dipropionate (Dovobet, Daivobet) for the treatment of psoriasis.

Journal: Skin therapy letter 20030101

Title: [Effect of admixture of betamethasone butyrate propionate ointment on preservative efficacy].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20021201

Title: Clotrimazole/betamethasone diproprionate: a review of costs and complications in the treatment of common cutaneous fungal infections.

Journal: Pediatric dermatology 20020101

Title: A new calcipotriol/betamethasone formulation with rapid onset of action was superior to monotherapy with betamethasone dipropionate or calcipotriol in psoriasis vulgaris.

Journal: Acta dermato-venereologica 20020101

Title: Suppression of spontaneous scratching in hairless rats by sedatives but not by antipruritics.

Journal: Skin pharmacology and applied skin physiology 20020101

Title: Pharmaceutical availability of betamethasone dipropionate and gentamicin sulfate from cream and ointment.

Journal: Acta poloniae pharmaceutica 20020101

Title: A new calcipotriol/betamethasone dipropionate formulation (Daivobet) is an effective once-daily treatment for psoriasis vulgaris.

Journal: Dermatology (Basel, Switzerland) 20020101

Title: A topical steroid without an antibiotic cures external otitis efficiently: a study in an animal model.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20010801

Title: Severe vulvovaginitis associated with intravaginal nystatin therapy.

Journal: American journal of obstetrics and gynecology 20010701

Title: [Pemphigoid gestationis: treatment by topical class I corticosteroid].

Journal: Annales de dermatologie et de venereologie 20010501

Title: [Dyshidrosis and acral purpura during polymorphic dermatitis in pregnancy: 2 cases].

Journal: Annales de dermatologie et de venereologie 20010401

Title: Bias shown in study of better care for patients with skin disease?

Journal: Family medicine 20010201

Title: Femoral head osteonecrosis after topical corticosteroid therapy.

Journal: Clinical and experimental rheumatology 20010101

Title: Topical therapy with fluorinated and non-fluorinated corticosteroids in patients with atopic dermatitis.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20010101

Title: Treatment of psoriasis with a new combination of calcipotriol and betamethasone dipropionate: a flow cytometric study.

Journal: Dermatology (Basel, Switzerland) 20010101

Title: Hiccups with betamethasone dipropionate.

Journal: The Journal of rheumatology 20000301

Title: Contact allergies to topical corticosteroids.

Journal: Contact dermatitis 19930301

Title: Amcinonide vs. betamethasone dipropionate ointments in the treatment of psoriasis.

Journal: Cutis 19850501

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SDS
Tags:5593-20-4 Molecular Formula|5593-20-4 MDL|5593-20-4 SMILES|5593-20-4 Pregna-1,4-diene-3,20-dione,9-fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11b,16b)-