Home Other Building Blocks 62471-63-0
62471-63-0,MFCD03788704
Catalog No.:AA00EENI

62471-63-0 | 2'-deoxy-7,8-dihydro-8-oxoadenosine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
2 weeks  
$327.00   $229.00
- +
5mg
2 weeks  
$531.00   $372.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00EENI
Chemical Name:
2'-deoxy-7,8-dihydro-8-oxoadenosine
CAS Number:
62471-63-0
Molecular Formula:
C10H13N5O4
Molecular Weight:
267.2413
MDL Number:
MFCD03788704
SMILES:
OC[C@H]1O[C@H](C[C@@H]1O)n1c(O)nc2c1ncnc2N
Properties
Properties
 
Form:
Solid  
MP:
>130°C (dec.)  
Storage:
-20 ℃;Keep in dry area;  

Computed Properties
 
Complexity:
370  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
2  
XLogP3:
-1.5  

Literature

Title: Repair of oxidative DNA damage is delayed in the Ser326Cys polymorphic variant of the base excision repair protein OGG1.

Journal: Mutagenesis 20120701

Title: 8-Oxo-7,8-dihydrodeoxyadenosine: the first example of a native DNA lesion that stabilizes human telomeric G-quadruplex DNA.

Journal: Biochemical and biophysical research communications 20120518

Title: Catechol metabolites of zeranol and 17β-estradiol: a comparative in vitro study on the induction of oxidative DNA damage and methylation by catechol-O-methyltransferase.

Journal: Toxicology letters 20120405

Title: Harmonising measurements of 8-oxo-7,8-dihydro-2'-deoxyguanosine in cellular DNA and urine.

Journal: Free radical research 20120401

Title: The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions.

Journal: Mutation research 20120401

Title: Biomarker analysis for prostate cancer diagnosis using LC-MS and CE-MS.

Journal: Bioanalysis 20110901

Title: Effect of surgical stress on nuclear and mitochondrial DNA from healthy sections of colon and rectum of patients with colorectal cancer.

Journal: Journal of biosciences 20110601

Title: Divergent effects of oxidatively induced modification to the C8 of 2'-deoxyadenosine on transcription factor binding: 8,5'(S)-cyclo-2'-deoxyadenosine inhibits the binding of multiple sequence specific transcription factors, while 8-oxo-2'-deoxyadenosine increases binding of CREB and NF-kappa B to DNA.

Journal: Environmental and molecular mutagenesis 20110501

Title: Aberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer.

Journal: Molecular and cellular biochemistry 20110301

Title: Radical chemistry of 8-oxo-7,8-dihydro-2'-deoxyadenosine and 8-oxo-7,8-dihydro-2'-deoxyguanosine: a pulse radiolysis study.

Journal: The journal of physical chemistry. B 20101216

Title: Sulfur mustard analog induces oxidative stress and activates signaling cascades in the skin of SKH-1 hairless mice.

Journal: Free radical biology & medicine 20091201

Title: Elevated level of 8-oxo-7,8-dihydro-2'-deoxyguanosine in leukocytes of BRCA1 mutation carriers compared to healthy controls.

Journal: International journal of cancer 20091101

Title: Simultaneous determination of 8-oxo-2'-deoxyguanosine and 8-oxo-2'-deoxyadenosine in DNA using online column-switching liquid chromatography/tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20090101

Title: Inhibition of Rac and Rac-linked functions by 8-oxo-2'-deoxyguanosine in murine macrophages.

Journal: Free radical research 20090101

Title: Determination of 8-hydroxy-2'deoxyguanosine in urine using HPLC with electrochemical detection.

Journal: Arhiv za higijenu rada i toksikologiju 20081201

Title: Analysis of urinary 8-oxo-7,8-dihydro-purine-2'-deoxyribonucleosides by LC-MS/MS and improved ELISA.

Journal: Free radical research 20081001

Title: Efficient removal of formamidopyrimidines by 8-oxoguanine glycosylases.

Journal: Biochemistry 20080122

Title: Studies on the replication of the ring opened formamidopyrimidine, Fapy.dG in Escherichia coli.

Journal: Biochemistry 20070904

Title: The in vivo antioxidant action and the reduction of oxidative stress by boysenberry extract is dependent on base diet constituents in rats.

Journal: Journal of medicinal food 20070601

Title: Activity of OGG1 variants in the repair of pro-oxidant-induced 8-oxo-2'-deoxyguanosine.

Journal: DNA repair 20061108

Title: Recognition of oxidatively modified bases within the biotin-binding site of avidin.

Journal: Journal of molecular biology 20060317

Title: The mechanism of guanine specific photooxidation in the presence of berberine and palmatine: activation of photosensitized singlet oxygen generation through DNA-binding interaction.

Journal: Chemical research in toxicology 20051001

Title: Nitrative and oxidative DNA damage in oral lichen planus in relation to human oral carcinogenesis.

Journal: Cancer science 20050901

Title: Structure-activity relationship of phosmidosine: importance of the 7,8-dihydro-8-oxoadenosine residue for antitumor activity.

Journal: Bioorganic & medicinal chemistry 20041001

Title: Oxidative DNA damage induced by benz[a]anthracene metabolites via redox cycles of quinone and unique non-quinone.

Journal: Chemical research in toxicology 20031101

Title: Oxidative stress in lung epithelial cells from patients with idiopathic interstitial pneumonias.

Journal: The European respiratory journal 20030201

Title: Metal-mediated DNA damage induced by curcumin in the presence of human cytochrome P450 isozymes.

Journal: Archives of biochemistry and biophysics 20020915

Title: Base pairing properties of 8-oxo-7,8-dihydroadenosine in cDNA synthesis by reverse transcriptases.

Journal: Bioorganic & medicinal chemistry letters 20020805

Title: Urinary excretion of 8-oxo-7, 8-dihydro-2'-deoxyguanosine as a predictor of the development of diabetic nephropathy.

Journal: Diabetologia 20020601

Title: A comparative photomechanistic study (spin trapping, EPR spectroscopy, transient kinetics, photoproducts) of nucleoside oxidation (dG and 8-oxodG) by triplet-excited acetophenones and by the radicals generated from alpha-oxy-substituted derivatives through Norrish-type I cleavage.

Journal: Journal of the American Chemical Society 20020417

Title: Protective effect of phytic acid on oxidative DNA damage with reference to cancer chemoprevention.

Journal: Biochemical and biophysical research communications 20011102

Title: Photobleaching of asymmetric cyanines used for fluorescence imaging of single DNA molecules.

Journal: Journal of the American Chemical Society 20010822

Title: Measurement of 8-oxo-2'-deoxyguanosine and 8-oxo-2'-deoxyadenosine in DNA and human urine by high performance liquid chromatography-electrospray tandem mass spectrometry.

Journal: Free radical biology & medicine 20010401

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:62471-63-0 Molecular Formula|62471-63-0 MDL|62471-63-0 SMILES|62471-63-0 2'-deoxy-7,8-dihydro-8-oxoadenosine