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855-96-9,MFCD00016929
Catalog No.:AA003MPK

855-96-9 | 3',5-DIHYDROXY-4',6,7-TRIMETHOXYFLAVONE

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10mg
≥98%
in stock  
$82.00   $57.00
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25mg
≥98%
in stock  
$159.00   $111.00
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50mg
≥98%
in stock  
$298.00   $208.00
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100mg
95%
in stock  
$427.00   $299.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003MPK
Chemical Name:
3',5-DIHYDROXY-4',6,7-TRIMETHOXYFLAVONE
CAS Number:
855-96-9
Molecular Formula:
C18H16O7
Molecular Weight:
344.3154
MDL Number:
MFCD00016929
SMILES:
COc1cc2oc(cc(=O)c2c(c1OC)O)c1ccc(c(c1)O)OC
NSC Number:
106402
Properties
Properties
 
BP:
587°C at 760 mmHg  
Form:
Solid  
MP:
194-196°C  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
520  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
2.9  

Literature

Title: Antiproliferative and antiangiogenic effects of flavone eupatorin, an active constituent of chloroform extract of Orthosiphon stamineus leaves.

Journal: Fitoterapia 20120901

Title: A simple isocratic HPLC method for the simultaneous determination of sinensetin, eupatorin, and 3'-hydroxy-5,6,7,4'-tetramethoxyflavone in Orthosiphon stamineus extracts.

Journal: Journal of acupuncture and meridian studies 20120801

Title: Bioactivity-guided isolation of antiproliferative compounds from Centaurea jacea L.

Journal: Fitoterapia 20120701

Title: Flavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activation.

Journal: Planta medica 20120501

Title: The flavonoid eupatorin inactivates the mitotic checkpoint leading to polyploidy and apoptosis.

Journal: Experimental cell research 20120310

Title: Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.

Journal: Bioorganic & medicinal chemistry 20110501

Title: In vitro effects of active constituents and extracts of Orthosiphon stamineus on the activities of three major human cDNA-expressed cytochrome P450 enzymes.

Journal: Chemico-biological interactions 20110315

Title: Evaluation of the genotoxicity of Orthosiphon stamineus aqueous extract.

Journal: Journal of ethnopharmacology 20110127

Title: In vitro modulatory effects of Andrographis paniculata, Centella asiatica and Orthosiphon stamineus on cytochrome P450 2C19 (CYP2C19).

Journal: Journal of ethnopharmacology 20110127

Title: Antiapoptotic and Antioxidant Properties of Orthosiphon stamineus Benth (Cat's Whiskers): Intervention in the Bcl-2-Mediated Apoptotic Pathway.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions.

Journal: Malaria journal 20110101

Title: Hepatoprotective Effects of Orthosiphon stamineus Extract on Thioacetamide-Induced Liver Cirrhosis in Rats.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Antimetastatic effects of Phyllanthus on human lung (A549) and breast (MCF-7) cancer cell lines.

Journal: PloS one 20110101

Title: Is propolis safe as an alternative medicine?

Journal: Journal of pharmacy & bioallied sciences 20110101

Title: Flavones and rosmarinic acid from Salvia limbata.

Journal: Natural product research 20101201

Title: Bioactivity-guided isolation of antiproliferative compounds from Centaurea arenaria.

Journal: Phytotherapy research : PTR 20101101

Title: HPLC and anti-inflammatory studies of the flavonoid rich chloroform extract fraction of Orthosiphon stamineus leaves.

Journal: Molecules (Basel, Switzerland) 20100621

Title: The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells.

Journal: Journal of natural products 20090801

Title: Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract.

Journal: Inflammopharmacology 20090201

Title: Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention.

Journal: BMC cancer 20090101

Title: Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism.

Journal: Breast cancer research : BCR 20080101

Title: Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidant activity of the fruit extracts and their constituents.

Journal: Phytotherapy research : PTR 20070401

Title: New Bisabolane-Type Sesquiterpenes from the Aerial Parts of Lippia dulcis.

Journal: Chemical & pharmaceutical bulletin 20050901

Title: Determination of flavonoids from Orthosiphon stamineus in plasma using a simple HPLC method with ultraviolet detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050225

Title: Phytochemical and pharmacological studies on Orthosiphon stamineus Benth. (Lamiaceae) hydroalcoholic extracts.

Journal: Journal of pharmaceutical and biomedical analysis 20030915

Title: Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship.

Journal: Biological & pharmaceutical bulletin 20020701

Title: Estévez S, et al. Eupatorin-induced cell death in human leukemia cells is dependent on caspases and activates the mitogen-activated protein kinase pathway. PLoS One. 2014 Nov 12;9(11):e112536.

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Tags:855-96-9 Molecular Formula|855-96-9 MDL|855-96-9 SMILES|855-96-9 3',5-DIHYDROXY-4',6,7-TRIMETHOXYFLAVONE