Home Amines 86541-78-8
86541-78-8,MFCD00864465
Catalog No.:AA008FLT

86541-78-8 | 1H-1-Benzazepine-1-aceticacid, 3-[[(1S)-1-carboxy-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, (3S)-

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1mg
≥98%
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$98.00   $68.00
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5mg
≥98%
in stock  
$409.00   $286.00
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10mg
≥98%
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$765.00   $535.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008FLT
Chemical Name:
1H-1-Benzazepine-1-aceticacid, 3-[[(1S)-1-carboxy-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, (3S)-
CAS Number:
86541-78-8
Molecular Formula:
C22H24N2O5
Molecular Weight:
396.4364
MDL Number:
MFCD00864465
SMILES:
OC(=O)CN1C(=O)[C@H](CCc2c1cccc2)N[C@H](C(=O)O)CCc1ccccc1
Properties
Computed Properties
 
Complexity:
590  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  
XLogP3:
0.6  

Literature

Title: Simultaneous determination of lercanidipine, benazepril and benazeprilat in plasma by LC-MS/MS and its application to a toxicokinetics study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120615

Title: Antihypertensive and organ-protective effects of benazepril.

Journal: Expert review of cardiovascular therapy 20101201

Title: Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production.

Journal: American journal of physiology. Heart and circulatory physiology 20080401

Title: Simultaneous and rapid quantitation of benazepril and benazeprilat in human plasma by high performance liquid chromatography with ultraviolet detection.

Journal: Journal of pharmaceutical and biomedical analysis 20070509

Title: Angiotensin-converting enzyme inhibitors in veterinary medicine.

Journal: Current pharmaceutical design 20070101

Title: Development and validation of a liquid chromatographic/electrospray ionization mass spectrometric method for the determination of benazepril, benazeprilat and hydrochlorothiazide in human plasma.

Journal: Journal of mass spectrometry : JMS 20060501

Title: Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats.

Journal: Journal of hypertension 20050201

Title: Simultaneous determination of benazepril hydrochloride and benazeprilat in plasma by high-performance liquid chromatography/electrospray-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050125

Title: Pharmacokinetic/pharmacodynamic modelling of the disposition and effect of benazepril and benazeprilat in cats.

Journal: Journal of veterinary pharmacology and therapeutics 20030601

Title: An angiotensin converting enzyme inhibitor, benazepril can be transformed to an active metabolite, benazeprilat, by the liver of dogs with ascitic pulmonary heartworm disease.

Journal: The Journal of veterinary medical science 20030601

Title: Quantitative determination of benazepril and benazeprilat in human plasma by gas chromatography-mass spectrometry using automated 96-well disk plate solid-phase extraction for sample preparation.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030105

Title: Effect of renal insufficiency on the pharmacokinetics and pharmacodynamics of benazepril in cats.

Journal: Journal of veterinary pharmacology and therapeutics 20021001

Title: Kinetics of the acidic and enzymatic hydrolysis of benazepril HCl studied by LC.

Journal: Journal of pharmaceutical and biomedical analysis 20020101

Title: Myocardial bradykinin following acute angiotensin-converting enzyme inhibition, AT1 receptor blockade, or combined inhibition in congestive heart failure.

Journal: Journal of cardiovascular pharmacology and therapeutics 20011001

Title: Pharmacokinetics and pharmacodynamics of benazepril hydrochloride in patients with major proteinuria.

Journal: European journal of clinical pharmacology 19930101

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Tags:86541-78-8 Molecular Formula|86541-78-8 MDL|86541-78-8 SMILES|86541-78-8 1H-1-Benzazepine-1-aceticacid, 3-[[(1S)-1-carboxy-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, (3S)-