PIII-Chelation-Assisted Indole C7-Arylation, Olefination, Methylation, and Acylation with Carboxylic Acids/Anhydrides by Rhodium Catalysis

Xiaodong Qiu, Panpan Wang, Dingyi Wang, Minyan Wang, Yu Yuan, and Zhuangzhi Shi

As a heteroaromatic scaffold frequently found in natural products, pharmaceuticals, and biologically active compounds, indole nuclei-containing structures have garnered tremendous attention over the past century.[1] In this context, the regioselective functionalization of indole C@H bonds has long attracted the interest of synthetic chemists.[2] To date, the C@H functionalization of indole at the C3 or C2 position has been successfully achieved by transition metal catalysis. [3] Due to the inherent reactivity of the pyrrole side of the indole, the development of methodologies to control the positional selectivity on the benzenoid core has remained a great challenge.[4] Traditional methods to synthesize indole C7-linkage natural compounds mainly rely on the prefunctionalization of the C7 position in the form of leaving groups (such as Br, OTf, BR2, SnR3) [5] with coupling partners using transition metal catalysis. For instance, a palladium-mediated intramolecular Stille reaction between the 7-stannylindole and iodoarene was used as a key step in total synthesis of Chloropeptin I-an anti-HIV agent (Figure 1 a).[5b] Remarkably, a smart biosynthetic way to prepare such indole C7-linkage cyclic peptides has evolved in nature. In the biosynthesis of streptide, a covalent linkage formed directly between the C7 position of indole and the side chains of lysine by enzyme StrB.[6] Inspired by this biochemical process, the development of a unified way to directly and selectively access the indole C@H bond at the C7 position for diverse transformations, without prefunctionalization, is extremely meaningful.

Selective C@H activation of indole at the C7 position is achieved by installing the substituents at the C2 or C3 position to block the reactivity at this side[7] or using indoline as a precursor.[8] Recently, some elegant methods have been developed by utilizing the C7-selective directing groups.[9] In 2016, we developed a PV directing group (N-P(O)tBu2) that is able to perform PdII-catalyzed oxidative Suzuki coupling at the C7 position of indoles with aryl boronic acids by O atom coordination in the presence of stoichiometric metal salts including Ag2O, Cu(OTf)2, and CuO as the co-oxidants.[10]

Recently, our group also reported the rational design of a PIII directing group (N-PtBu2) that directs C7@H functionalization of indoles with olefins through rhodium catalysis. [11] This novel directing group opens a door for indole functionalization. Herein, we describe the development of the decarbonylative cross-couplings[12] of carboxylic acids or anhydrides with indoles at the C7 position by P
III-chelation-assisted RhI-catalyzed C@H and C@C bond activation. The indole PIII atom binds to the Rh center and selectively delivers the catalyst to the C7 position, which subsequently undergoes decarbonylative arylation, olefination, and methylation. Additionally, the decarbonylation process can also be suppressed at a lower reaction temperature to yield indole C7-acylation products.[13]

Our investigation commenced with the decarbonylative cross-coupling of N-PtBu2 indole 1 a and benzoic anhydride (2 a) to yield C7-phenylation product 3 aa (Table 1). After optimization of the reaction conditions, the best results were obtained with a catalytic amount of [Rh(cod)Cl]2 and NaHCO3 as a base in toluene within 12 h at 1508C without any external ligands or oxidants. Under these conditions,
conversion was completed with a 99% yield of the desired product 3 aa (entry 1). Other rhodium complexes such as [Rh(CO)2Cl]2 and Rh(cod)2OTf were less efficient for this reaction (entries 2 and 3). A control experiment revealed that the cross-coupling process does not occur in the absence of the rhodium catalyst (entry 4). Using Na2CO3 as the additive led to slight erosion in yield (entry 5). Under these conditions, when PhCOOH (2 a’) was employed as a phenyl source with (tBuCO)2O, the conversion was poor (entry 6); however, a significant improvement in conversion was observed by using PhCOOBoc (2 a’’) in this reaction (entry 7). Finally, lowering the temperature to 1308C had a substantial impact on the reaction outcome (entry 8).

With the best conditions identified, we first examined the scope of this PIII-directed C7-arylation process (Table 2). Decarbonylative cross-coupling reactions of benzoic anhydride (2 a) with a broad range of N-PtBu2 indoles were first examined. Indoles bearing electron-neutral and donating substituents including methyl (3 ba, 3 ca), phenyl (3 da), and methoxy (3 ea) at the C3–C5 positions underwent facile
olefination affording the corresponding products in good to excellent yields. The halogen-containing motifs such as F (3 fa–3 ga) and Cl (3 ha) work very well in the C7-olefination; however, an indole with a Br-substituent such as 1i gave a trace amount of product 3ia. Indole substrates containing electron-deficient substituents such as a cyano (3 ja) group were also converted in good efficiency. Substrates with strong chelating groups at the C3 position such as acetyl (3 ka), cyanomethyl (3la), p-tolylthio (3ma), and amide (3 na) were well tolerated with good C7-selectivity, and C4-arylation products were not observed. In particular, the treatment of tryptophan derivative 1 o under standard conditions provided 7-phenyl tryptophan derivative 3 oa in excellent yield. Additionally to indole, PIII-protected carbazole can also be converted into product 3 pa in 73% yield. We also examined the scope of different carboxylic acid anhydrides with indole 1 a. The functional group compatibility of this method was nicely illustrated by the fact that Me (3 ab, 3 ac), OMe (3 ad), SMe (3 ae), OCF3 (3 af), F (3 ag), Cl (3 ah–3 ai), Ac (3 aj), CN (3 ak), and COOMe (3 al) at aryl motif of carboxylic acid anhydride and 2-naphthoic anhydride (3 am) could all be equally accommodated. Moreover, a series of heteroarenes such as furan (3 an), thiophene (3 ao–3 ap), and benzothiophene (3 aq) could also be installed to the C7 position of
indole.

The decarbonylative reaction was further optimized with cinnamic acid (4 a) as a partner to produce the indole C7-olefination products, [8b, 9b] avoiding the use of the noncommercially available cinnamic acid anhydride (Table 3). We found that the reaction reached the optimal efficiency and selectivity with 2.5 equiv of Boc2O in the presence of 5.0 mol% of Rh(cod)2OTf as catalyst. Product 5 aa was obtained in 93% yield after reaction at 120 8C for 18 h under argon atmosphere. As shown, all indole and carbazole substrates shown in arylation reaction could be applied in C7-olefination reactions (5 ba–5 pa).

Under these reaction conditions, the Br-substituted indole 1i was compatible, affording the desired product 5ia in 81% yield. Notably, the Boc group in tryptophan product 5 oa (54%) was deprotected during the olefination process. A wide range of cinnamic acids that incorporate electron-neutral, electron-donating and electron-withdrawing substituents on arenes were readily tolerated as well (5 ab–5 aj). Among them, the structure of product 5 ag was confirmed by X-ray analysis. Naphthalene substrates (5 ak, 5 al) were also shown to exhibit high levels of reactivity. However, some vinyl carboxylic acids including trans-2-pentenoic acid (4m) and fumaric acid monomethyl ester (4 n) did not work in our system.

Methylation is fundamental in medicinal chemistry, which can have a profound influence on biologically active molecules. [14] Typical methods to form a methylarene involve strong nucleophiles or strong and often toxic electrophiles. We were excited to find that, the PIII-directed decarbonylative methylation could also occur using the inexpensive and nontoxic acetic anhydride as a methylating reagent. The
desired C7-methylation product 6 was formed in 53% yield at current reaction conditions (Scheme 1). Except acetic anhydride, other aliphatic carboxylic anhydrides like propionic anhydride and isobutyric anhydride were not compatible in these reaction conditions.

The reaction of indoles with carboxylic anhydrides in the presence of Lewis acids, Friedel–Crafts acylation, is widely known as a general method for the C3-acylation of indoles.[15] The decarbonylation process of carboxylic anhydrides can be significantly suppressed at a lower reaction temperature, in a slightly modified PIII-directed system, and indole acylation products can be generated, unlike the regioselectivity of traditional Friedel–Crafts methods (Scheme 2). C7-acylation product 7 aa was obtained at 100 8C for 16 h with a trace amount of decarbonylative byproduct 3 aa (9%), which was
also confirmed by X-ray analysis. Other indoles such as 1 b, 1 d, and 1i, and carboxylic anhydrides such as 2 b, 2 d as well as 2-naphthoic anhydride 2m can undergo C7-acylation to obtain the corresponding aromatic ketone products in 40–61% yields.

This PIII-directed cross-coupling reaction was also viable with late-stage modification (Scheme 3). For example, anhydride 8 derived from Adapalene, a second-generation topical retinoid primarily used in the treatment of mild-moderate acne, can be subjected to decarbonylative C7-arylation with indole 1 a to produce the product 9 in 88% isolated yield. Furthermore, this directing group can be easily removed by TBAF in THF, and 82% of N-free indole 10 was isolated.

Although the detailed mechanism of the reaction remains unclear, we propose a tentative catalytic cycle as shown in Figure 2.[16] Rhodium A coordinates first to the PIII atom of the indole 1, leading to the formation of complex B. A reversible cyclometalation through an anion-assisted deprotonation[17] at the indole C7 position delivers the intermediate C, which induces oxidative addition to generate the RhIIIH species D.[11] Elimination of intermediate D gives the rhodacycle E. Then oxidative addition of the carboxylic anhydrides 2 or 4’ to E affords the intermediate F. Subsequent decarboxylation can yield the rhodium species G. Further reductive elimination and dissociation delivers the final products and regenerates the active catalyst. At a lower temperature, decarboxylation can be inhibited from acylrhodium complex Faffording the acylation products by reductive elimination.

In summary, we have reported an efficient C7-selective direct arylation, olefination, methylation, and acylation of indoles with the aid of the PIII-directed group by rhodium catalysis. The reaction employed commercially available carboxylic acids or anhydrides, does not require the addition of an exogenous ligand, and is applicable to the coupling of a variety of indoles. These results represent an important
discovery that is expected to be substantially extended to other new transformations.

Acknowledgements
We thank the NSF of China (Grant 2167020084), Jiangsu provincial “Innovation & Entrepreneurship Talents Plan”, and Jiangsu provincial “Outstanding Youth Funds” for their financial support.

How to cite: Angew. Chem. Int. Ed. 2019, 58, 1504– 1508 Angew. Chem. 2019, 131, 1518– 1522

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tert-Butyl ((1-benzhydrylazetidin-3-yl)methyl)(methyl)carbamate Catalog No.:AA019EYK CAS No.:1064048-70-9 MDL No.:MFCD30185068 MF:C23H30N2O2 MW:366.4965	ART-CHEM-ACB ACB008229 Catalog No.:AA01EKGW CAS No.:1064074-57-2 MDL No.:MFCD15142990 MF:C18H19N3O5 MW:357.3606
2-(dimethylamino)-2-methylpropane-1,3-diol hydrochloride Catalog No.:AA01AU95 CAS No.:1064076-22-7 MDL No.:MFCD29034838 MF:C6H16ClNO2 MW:169.6497	N-Boc-ε-caprolactam Catalog No.:AA003SRK CAS No.:106412-36-6 MDL No.:MFCD03265235 MF:C11H19NO3 MW:213.2735
1-Bromo-4-decylbenzene Catalog No.:AA003AYG CAS No.:106418-67-1 MDL No.:MFCD00061112 MF:C16H25Br MW:297.2737	2,3-Dichlorophenylmethylsulfone Catalog No.:AA0083OL CAS No.:106418-92-2 MDL No.:MFCD03789181 MF:C7H6Cl2O2S MW:225.0923
tert-Butyl 3-bromoazetidine-1-carboxylate Catalog No.:AA008Z00 CAS No.:1064194-10-0 MDL No.:MFCD16658899 MF:C8H14BrNO2 MW:236.1063	2-Butene-1,4-bis(triphenylphosphonium chloride) Catalog No.:AA003GQM CAS No.:106423-29-4 MDL No.:MFCD09953458 MF:C40H36Cl2P2 MW:649.5674
Methyl 3-fluoro-2-methoxybenzoate Catalog No.:AA008YTY CAS No.:106428-04-0 MDL No.:MFCD09753133 MF:C9H9FO3 MW:184.1644	3-Fluoro-2-methoxybenzoic acid Catalog No.:AA007CI4 CAS No.:106428-05-1 MDL No.:MFCD00973972 MF:C8H7FO3 MW:170.1378
1-(4-Hydroxy-3,5-bis(morpholinomethyl)phenyl)ethanone Catalog No.:AA00HAQF CAS No.:1064288-38-5 MDL No.:MFCD28657199 MF:C17H24N2O4 MW:320.3835	(2-Aminobenzo[d]thiazol-6-yl)methanol Catalog No.:AA0093IY CAS No.:106429-07-6 MDL No.:MFCD11976758 MF:C8H8N2OS MW:180.2269
2-Aminobenzo[d]thiazole-6-carbaldehyde Catalog No.:AA0093JA CAS No.:106429-08-7 MDL No.:MFCD11976759 MF:C8H6N2OS MW:178.2110	1H-Benzimidazol-5-ylmethanol Catalog No.:AA003M4S CAS No.:106429-29-2 MDL No.:MFCD08690267 MF:C8H8N2O MW:148.1619
Methyl 2-amino-1h-benzimidazole-5-carboxylate Catalog No.:AA0037WW CAS No.:106429-38-3 MDL No.:MFCD08752985 MF:C9H9N3O2 MW:191.1867	Methyl 2-hydroxy-3h-benzo[d]imidazole-5-carboxylate Catalog No.:AA0083OJ CAS No.:106429-57-6 MDL No.:MFCD08457979 MF:C9H8N2O3 MW:192.1714
2-Oxo-2,3-dihydro-1h-benzo[d]imidazole-5-carbaldehyde Catalog No.:AA003935 CAS No.:106429-59-8 MDL No.:MFCD18807917 MF:C8H6N2O2 MW:162.1454	(1H-Benzo[d][1,2,3]triazol-5-yl)methanol Catalog No.:AA007UVH CAS No.:106429-67-8 MDL No.:MFCD00963121 MF:C7H7N3O MW:149.1500
1-(but-3-en-1-yl)cyclopropane-1-carboxylic acid Catalog No.:AA01BGYT CAS No.:106434-86-0 MDL No.:MFCD19229145 MF:C8H12O2 MW:140.1797	(5E)-5-(3-hydroxybenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one Catalog No.:AA00J0TH CAS No.:1064365-95-2 MDL No.:MFCD04054471 MF:C10H7NO2S2 MW:237.2981
(5E)-5-(3,4-dichlorobenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one Catalog No.:AA00J0TE CAS No.:1064366-80-8 MDL No.:MFCD04969010 MF:C10H5Cl2NOS2 MW:290.1888	8-Methoxycarbonyloctyl4-O-(3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-b-D-glucopyranosyl)-2-deoxy-3-O-benzyl-2-phthalimido-b-D-glucopyranoside Catalog No.:AA008SKW CAS No.:106445-30-1 MDL No.:MFCD02094273 MF:C51H58N2O18 MW:987.0088
8-Methoxycarbonyloctyl2-acetamido-4-O-(2-acetamido-2-deoxy-b-D-glucopyranosyl)-2-deoxy-6-O-(a-L-fucopyranosyl)-b-D-glucopyranoside Catalog No.:AA008YJ6 CAS No.:106445-35-6 MDL No.: MF:C32H56N2O17 MW:740.7902	3-methyl-1,2-oxazole-4-carbaldehyde Catalog No.:AA01BA32 CAS No.:1064458-79-2 MDL No.:MFCD10700235 MF:C5H5NO2 MW:111.0987
4-(Trifluoromethyl)pyridin-2-amine Catalog No.:AA003GBI CAS No.:106447-97-6 MDL No.:MFCD00077455 MF:C6H5F3N2 MW:162.1125	2-(hydroxymethyl)thiophene-3-carbonitrile Catalog No.:AA01EM7I CAS No.:106449-27-8 MDL No.:MFCD28059603 MF:C6H5NOS MW:139.1750
2'-Deoxyisoguanosine Catalog No.:AA00HAQI CAS No.:106449-56-3 MDL No.:MFCD15145285 MF:C10H13N5O4 MW:267.2413	6-N-Biotinylaminohexanol Catalog No.:AA0083OD CAS No.:106451-92-7 MDL No.:MFCD03788815 MF:C16H29N3O3S MW:343.4848
N-Boc-D-phenylalaninol Catalog No.:AA0083OC CAS No.:106454-69-7 MDL No.:MFCD00216472 MF:C14H21NO3 MW:251.3214	1-(4-fluorophenyl)-1H-1,3-benzodiazol-2-amine Catalog No.:AA01A4CI CAS No.:106461-31-8 MDL No.:MFCD11202307 MF:C13H10FN3 MW:227.2370
1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one Catalog No.:AA007CHZ CAS No.:106461-41-0 MDL No.:MFCD02093087 MF:C22H27N5O2 MW:393.4821	1-Chloro-5-methoxyisoquinoline Catalog No.:AA007UV9 CAS No.:106462-85-5 MDL No.:MFCD11846291 MF:C10H8ClNO MW:193.6296
Tamsulosin hydrochloride Catalog No.:AA00HAQJ CAS No.:106463-17-6 MDL No.:MFCD00922997 MF:C20H29ClN2O5S MW:444.9727	(S)-Tamsulosin Hydrochloride Catalog No.:AA008W0S CAS No.:106463-19-8 MDL No.:MFCD12031365 MF:C20H29ClN2O5S MW:444.9727
2-[[4-Nitro-2-(phenylmethoxy)phenoxy]methyl]oxirane Catalog No.:AA00HAQK CAS No.:1064662-53-8 MDL No.:MFCD15144533 MF:C16H15NO5 MW:301.2940	(3-Bromo-5-chloropyridin-4-yl)methanol Catalog No.:AA019EMV CAS No.:1064677-18-4 MDL No.:MFCD16606989 MF:C6H5BrClNO MW:222.4670
3-Bromo-5-chloropyridine-4-carboxaldehyde Catalog No.:AA00HAQM CAS No.:1064678-66-5 MDL No.:MFCD16606503 MF:C6H3BrClNO MW:220.4511	2-(4-chlorophenyl)-2-fluoroacetonitrile Catalog No.:AA01BHAR CAS No.:106468-05-7 MDL No.:MFCD28039202 MF:C8H5ClFN MW:169.5834
5-Chloro-3-methyl-4-amino-1h-pyrazole Catalog No.:AA00HAQO CAS No.:1064687-15-5 MDL No.:MFCD17015936 MF:C4H6ClN3 MW:131.5635	2-Des(5-methyl-1,3,4-oxadiazole-2-carboxamide) 2-(2-Amino-2-oxoacetic Acid) Raltegravir Catalog No.:AA01CBGQ CAS No.:1064706-98-4 MDL No.: MF:C18H19FN4O6 MW:406.3651
5-Chloro-3-fluoro-2-nitropyridine Catalog No.:AA008Z1W CAS No.:1064783-29-4 MDL No.:MFCD19690192 MF:C5H2ClFN2O2 MW:176.5330	3',5,5'-Trichlorosalicylanilide Catalog No.:AA008W91 CAS No.:106480-60-8 MDL No.: MF:C13H8Cl3NO2 MW:316.5671
3-{[2-amino-4-(trifluoromethyl)phenyl]amino}propanoic acid Catalog No.:AA00IRXN CAS No.:106484-66-6 MDL No.:MFCD03848689 MF:C10H11F3N2O2 MW:248.2017	4-((2-Amino-4-(trifluoromethyl)phenyl)amino)butanoic acid Catalog No.:AA00IQPQ CAS No.:106484-67-7 MDL No.:MFCD06659587 MF:C11H13F3N2O2 MW:262.2283
(2E,4E)-5-(4-Fluorophenyl)penta-2,4-dienal Catalog No.:AA007UL5 CAS No.:106485-23-8 MDL No.:MFCD02975821 MF:C11H9FO MW:176.1870	4-Methylumbelliferyl alpha-L-rhamnopyranoside Catalog No.:AA00JKH3 CAS No.:106488-05-5 MDL No.:MFCD00171591 MF:C16H18O7 MW:322.3099
Aminooxy-peg4-alcohol Catalog No.:AA0083O0 CAS No.:106492-60-8 MDL No.:MFCD30828691 MF:C8H19NO5 MW:209.2402	4-[(1E)-(propylimino)methyl]phenol Catalog No.:AA00IT4W CAS No.:106493-25-8 MDL No.:MFCD01090586 MF:C10H13NO MW:163.2163
(S)-3-Methyl-2-phenylbutylamine Catalog No.:AA0032EC CAS No.:106498-32-2 MDL No.:MFCD16620484 MF:C11H17N MW:163.2594	N,N'-Diisopropylacetimidamide Catalog No.:AA0095XB CAS No.:106500-93-0 MDL No.:MFCD19217938 MF:C8H18N2 MW:142.2419
Potassium cyclopropyltrifluoroborate Catalog No.:AA0039KP CAS No.:1065010-87-8 MDL No.:MFCD09265031 MF:C3H5BF3K MW:147.9763	Potassium cyclobutyltrifluoroboranuide Catalog No.:AA0096CU CAS No.:1065010-88-9 MDL No.:MFCD09992884 MF:C4H7BF3K MW:162.0029
BOLDENONE CYPIONATE Catalog No.:AA008R6E CAS No.:106505-90-2 MDL No.:MFCD31654717 MF:C27H38O3 MW:410.5888	2-methyl-2,3-dihydro-1h-isoindole-5-carboxylic acid hydrochloride Catalog No.:AA0091JL CAS No.:1065065-38-4 MDL No.:MFCD20527758 MF:C10H12ClNO2 MW:213.6608
6-METHYL-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID HYDROC+ Catalog No.:AA01DX6X CAS No.:1065065-54-4 MDL No.:MFCD22571273 MF:C9H12ClNO2S MW:233.7151	(2-Methyloxazol-5-yl)methanol Catalog No.:AA009273 CAS No.:1065073-48-4 MDL No.:MFCD11101415 MF:C5H7NO2 MW:113.1146
3-Fluoro-2-methyl-5-(trifluoromethyl)aniline Catalog No.:AA003JCF CAS No.:1065073-89-3 MDL No.:MFCD11053832 MF:C8H7F4N MW:193.1415	N-Isopropyl 3-bromo-4-fluorobenzamide Catalog No.:AA003T1O CAS No.:1065073-97-3 MDL No.:MFCD11053795 MF:C10H11BrFNO MW:260.1028
N-Ethyl 3-bromo-4-fluorobenzamide Catalog No.:AA003SWF CAS No.:1065073-98-4 MDL No.:MFCD11053796 MF:C9H9BrFNO MW:246.0763	N-Cyclohexyl 3-bromo-4-fluorobenzamide Catalog No.:AA003STW CAS No.:1065074-00-1 MDL No.:MFCD11504867 MF:C13H15BrFNO MW:300.1667
N-Butyl 3-bromo-4-fluorobenzamide Catalog No.:AA003SRR CAS No.:1065074-05-6 MDL No.:MFCD11053800 MF:C11H13BrFNO MW:274.1294	3,6-Dibromoimidazo[1,2-a]pyridine Catalog No.:AA003INI CAS No.:1065074-14-7 MDL No.:MFCD11504879 MF:C7H4Br2N2 MW:275.9281
4-(3-Chloro-4-methylphenyl)-1H-1,2,4-triazol-5(4H)-one Catalog No.:AA0083H9 CAS No.:1065074-18-1 MDL No.:MFCD11053883 MF:C9H8ClN3O MW:209.6323	4-Bromo-2-(4-methoxyphenoxy)thiazole Catalog No.:AA003KSF CAS No.:1065074-21-6 MDL No.:MFCD11053890 MF:C10H8BrNO2S MW:286.1450
5-Bromo-8-trifluoromethoxyquinoline Catalog No.:AA007UL0 CAS No.:1065074-23-8 MDL No.:MFCD11504881 MF:C10H5BrF3NO MW:292.0520	6-Fluoro-8-trifluoromethylquinoline Catalog No.:AA003N51 CAS No.:1065074-24-9 MDL No.:MFCD11504882 MF:C10H5F4N MW:215.1470
Methyl 5-(3-chlorophenyl)isoxazole-4-carboxylate Catalog No.:AA003RTO CAS No.:1065074-27-2 MDL No.:MFCD11504883 MF:C11H8ClNO3 MW:237.6391	6-Bromo-8-trifluoromethylquinoline Catalog No.:AA0083H8 CAS No.:1065074-30-7 MDL No.:MFCD11504884 MF:C10H5BrF3N MW:276.0526
Ethyl 2-(4-(t-BOC)piperazin-1-yl)-4-hydroxypyrimidine-5-carboxylate Catalog No.:AA007UKZ CAS No.:1065074-31-8 MDL No.:MFCD11504885 MF:C16H24N4O5 MW:352.3856	3-(2-Bromophenyl)-5-(2,3-dichlorophenyl)-1,2,4-oxadiazole Catalog No.:AA003HXI CAS No.:1065074-34-1 MDL No.:MFCD11053868 MF:C14H7BrCl2N2O MW:370.0282
1-(4-Bromo-3-trifluoromethylphenylsulfonyl)piperidine Catalog No.:AA0083H7 CAS No.:1065074-37-4 MDL No.:MFCD11053849 MF:C12H13BrF3NO2S MW:372.2013	4-Bromo-2-phenoxythiazole Catalog No.:AA008SRD CAS No.:1065074-43-2 MDL No.:MFCD11053888 MF:C9H6BrNOS MW:256.1190
Methyl 6-bromo-7-chloro-8-methyl-4-hydroxyquinoline-2-carboxylate Catalog No.:AA003RVM CAS No.:1065074-46-5 MDL No.:MFCD11053780 MF:C12H9BrClNO3 MW:330.5618	Methyl 6,8-difluoro-4-oxo-1,4-dihydroquinoline-2-carboxylate Catalog No.:AA0083H5 CAS No.:1065074-53-4 MDL No.:MFCD11053876 MF:C11H7F2NO3 MW:239.1750
Methyl 6,8-dichloro-4-oxo-1,4-dihydroquinoline-2-carboxylate Catalog No.:AA007CFK CAS No.:1065074-55-6 MDL No.:MFCD11053815 MF:C11H7Cl2NO3 MW:272.0842	Methyl 8-chloro-4-hydroxyquinoline-2-carboxylate Catalog No.:AA003RW9 CAS No.:1065074-57-8 MDL No.:MFCD11053822 MF:C11H8ClNO3 MW:237.6391
Methyl 2-amino-4-cyclopropylthiazole-5-carboxylate Catalog No.:AA008SRG CAS No.:1065074-61-4 MDL No.:MFCD11053814 MF:C8H10N2O2S MW:198.2422	Methyl 2-amino-4-(3-bromophenyl)thiazole-5-carboxylate Catalog No.:AA007CFJ CAS No.:1065074-63-6 MDL No.:MFCD11053871 MF:C11H9BrN2O2S MW:313.1704
Methyl 2-amino-4-(4-chlorophenyl)thiazole-5-carboxylate Catalog No.:AA008SRA CAS No.:1065074-65-8 MDL No.:MFCD11053872 MF:C11H9ClN2O2S MW:268.7194	Ethyl 5-(5-bromo-1H-indol-1-yl)pentanoate Catalog No.:AA003Q90 CAS No.:1065074-72-7 MDL No.:MFCD11053866 MF:C15H18BrNO2 MW:324.2129
2,4-Dichloro-5-methoxyphenyl methanesulfonate Catalog No.:AA003FNN CAS No.:1065074-74-9 MDL No.:MFCD11053813 MF:C8H8Cl2O4S MW:271.1177	3-Bromo-2-(N,N-diethylamino)-5-nitropyridine Catalog No.:AA003J1V CAS No.:1065074-82-9 MDL No.:MFCD11053789 MF:C9H12BrN3O2 MW:274.1145
3-Bromo-N-cyclopropyl-5-nitropyridin-2-amine Catalog No.:AA003J1Y CAS No.:1065074-85-2 MDL No.:MFCD11053788 MF:C8H8BrN3O2 MW:258.0720	3-Bromo-5-nitro-2-(piperidin-1-yl)pyridine Catalog No.:AA003J0G CAS No.:1065074-87-4 MDL No.:MFCD11053787 MF:C10H12BrN3O2 MW:286.1252
4-(3-Bromo-5-nitropyridin-2-yl)morpholine Catalog No.:AA003JY4 CAS No.:1065074-89-6 MDL No.:MFCD11053786 MF:C9H10BrN3O3 MW:288.0980	2-Acetamido-3-bromo-5-nitropyridine Catalog No.:AA003S7W CAS No.:1065074-93-2 MDL No.:MFCD11053862 MF:C7H6BrN3O3 MW:260.0448
Ethyl 3-bromo-6-chloropicolinate Catalog No.:AA003Q4L CAS No.:1065074-97-6 MDL No.:MFCD11053875 MF:C8H7BrClNO2 MW:264.5037	N-Methyl-4-(methylamino)picolinamide Catalog No.:AA007UKW CAS No.:1065074-98-7 MDL No.:MFCD11504981 MF:C8H11N3O MW:165.1924
tert-Butyl(chroman-4-yloxy)dimethylsilane Catalog No.:AA00HAQT CAS No.:1065075-49-1 MDL No.:MFCD11100910 MF:C15H24O2Si MW:264.4354	4-(Cyclohexylmethylamino)-2-(methylthio)pyrimidine-5-carboxylic acid Catalog No.:AA00HAQU CAS No.:1065075-52-6 MDL No.:MFCD11100915 MF:C13H19N3O2S MW:281.3739
2-(Methylthio)-4-(phenethylamino)pyrimidine-5-carboxylic acid Catalog No.:AA00HAQX CAS No.:1065075-61-7 MDL No.:MFCD11100918 MF:C14H15N3O2S MW:289.3528	2-(Methylthio)-4-(4-(trifluoromethyl)phenylamino)pyrimidine-5-carboxylic acid Catalog No.:AA00HAQY CAS No.:1065075-64-0 MDL No.:MFCD11100919 MF:C13H10F3N3O2S MW:329.2976
4-(Cyclopentylamino)-2-(methylthio)pyrimidine-5-carboxylic acid Catalog No.:AA00HAR0 CAS No.:1065075-68-4 MDL No.:MFCD11100923 MF:C11H15N3O2S MW:253.3207	3-(tert-Butoxycarbonylamino)-5-tert-butylisoxazole-4-carboxylic acid Catalog No.:AA00HAR2 CAS No.:1065075-72-0 MDL No.:MFCD11100928 MF:C13H20N2O5 MW:284.3083
4-(Dimethylamino)-2-(methylthio)pyrimidine-5-carboxylic acid Catalog No.:AA00HAR4 CAS No.:1065075-76-4 MDL No.:MFCD11100931 MF:C8H11N3O2S MW:213.2568	tert-Butyl 3-(allyloxy)-3-vinylpiperidine-1-carboxylate Catalog No.:AA00HAR7 CAS No.:1065075-83-3 MDL No.:MFCD11100937 MF:C15H25NO3 MW:267.3639
2-Bromo-4-fluoro-5-methylaniline Catalog No.:AA008Z5U CAS No.:1065076-39-2 MDL No.:MFCD11042843 MF:C7H7BrFN MW:204.0396	4-Ethyl-5-fluoro-2-methoxyphenol Catalog No.:AA00925D CAS No.:1065076-45-0 MDL No.:MFCD11101442 MF:C9H11FO2 MW:170.1808
2'-Fluoro-4'-hydroxy-5'-methoxyacetophenone Catalog No.:AA008STO CAS No.:1065076-49-4 MDL No.:MFCD11101445 MF:C9H9FO3 MW:184.1644	2-Bromo-1-(2-fluoro-4-hydroxy-5-methoxyphenyl)ethan-1-one Catalog No.:AA009ORP CAS No.:1065076-50-7 MDL No.:MFCD11101446 MF:C9H8BrFO3 MW:263.0604
4-Hydroxy-1,1-dioxo-1lambda(6)-thiolane-3-sulfonyl chloride Catalog No.:AA00VWA9 CAS No.:106508-20-7 MDL No.:MFCD00195962 MF:C4H7ClO5S2 MW:234.6784	Ethyl 4-isocyanatobutyrate Catalog No.:AA003Q8D CAS No.:106508-62-7 MDL No.:MFCD01863579 MF:C7H11NO3 MW:157.1671
3-Bromo-8-fluoro-4-hydroxyquinoline Catalog No.:AA00933Y CAS No.:1065087-83-3 MDL No.:MFCD13192868 MF:C9H5BrFNO MW:242.0445	3-Bromo-4-hydroxy-6-trifluoromethylquinoline Catalog No.:AA007CFG CAS No.:1065087-84-4 MDL No.:MFCD13192876 MF:C10H5BrF3NO MW:292.0520
3-Bromo-4-hydroxy-quinoline-6-carboxylic acid Catalog No.:AA0093KH CAS No.:1065088-02-9 MDL No.:MFCD28010344 MF:C10H6BrNO3 MW:268.0635	8-Bromo-5-fluoroquinolin-4-ol Catalog No.:AA007CFA CAS No.:1065092-35-4 MDL No.:MFCD15527288 MF:C9H5BrFNO MW:242.0445
8-Chloro-6-(trifluoromethyl)quinolin-4(1H)-one Catalog No.:AA00995O CAS No.:1065092-49-0 MDL No.:MFCD12827776 MF:C10H5ClF3NO MW:247.6010	4-Oxo-1,4-dihydro-quinoline-6-carboxylic acid Catalog No.:AA0083GZ CAS No.:1065092-81-0 MDL No.:MFCD16987424 MF:C10H7NO3 MW:189.1675
7-Bromo-4-methoxyquinoline Catalog No.:AA00945K CAS No.:1065092-89-8 MDL No.:MFCD09261108 MF:C10H8BrNO MW:238.0806	8-Bromo-4-chloro-5-fluoroquinoline Catalog No.:AA0093JQ CAS No.:1065093-11-9 MDL No.:MFCD15527289 MF:C9H4BrClFN MW:260.4902
4,8-Dichloro-6-(trifluoromethyl)quinoline Catalog No.:AA00IWOD CAS No.:1065093-22-2 MDL No.:MFCD12827783 MF:C10H4Cl2F3N MW:266.0467	8-Bromo-5-fluoro-4-hydroxy-quinoline-3-carboxylic acid Catalog No.:AA0093JR CAS No.:1065093-62-0 MDL No.:MFCD28010406 MF:C10H5BrFNO3 MW:286.0540
6-Fluoro-4-hydroxy-8-methylquinoline-3-carboxylic acid Catalog No.:AA01EK8H CAS No.:1065094-02-1 MDL No.:MFCD19685446 MF:C11H8FNO3 MW:221.1845	6-tert-Butyl-4-hydroxy-quinoline-3-carboxylic acid Catalog No.:AA0093I4 CAS No.:1065094-07-6 MDL No.:MFCD09743958 MF:C14H15NO3 MW:245.2738
3-Quinolinecarboxylic acid, 5-bromo-8-fluoro-4-hydroxy-, ethyl ester Catalog No.:AA01DTOP CAS No.:1065094-15-6 MDL No.:MFCD28010429 MF:C12H9BrFNO3 MW:314.1072	Ethyl 2-amino-5-methyloxazole-4-carboxylate Catalog No.:AA0092CC CAS No.:1065099-78-6 MDL No.:MFCD11054142 MF:C7H10N2O3 MW:170.1659
4-(Phenylsulfanyl)isoquinoline Catalog No.:AA01FEWL CAS No.:106510-95-6 MDL No.:MFCD05742386 MF:C15H11NS MW:237.3195	6-iodo-2-(trifluoromethyl)-1,4-dihydroquinolin-4-one Catalog No.:AA018S8I CAS No.:1065100-50-6 MDL No.:MFCD12114514 MF:C10H5F3INO MW:339.0525
1-Methyl-1,2,3-benzotriazole-5-carbonitrile Catalog No.:AA007UKS CAS No.:1065100-55-1 MDL No.:MFCD11054186 MF:C8H6N4 MW:158.1600	1H-Pyrrolo[2,3-b]pyridin-3-ylmethanol Catalog No.:AA0083GY CAS No.:1065100-83-5 MDL No.:MFCD11054203 MF:C8H8N2O MW:148.1619
tert-Butyl 4-((1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)piperazine-1-carboxylate Catalog No.:AA0094J0 CAS No.:1065100-86-8 MDL No.:MFCD11054205 MF:C17H24N4O2 MW:316.3981	N-(4-Bromo-2,5-difluorophenyl)acetamide Catalog No.:AA00HAR8 CAS No.:1065100-92-6 MDL No.:MFCD11054214 MF:C8H6BrF2NO MW:250.0401
4-(2-amino-1,3-thiazol-4-yl)benzamide Catalog No.:AA019N7W CAS No.:1065101-24-7 MDL No.:MFCD11054234 MF:C10H9N3OS MW:219.2630	4-(2-methoxyphenyl)-2-pyrimidinethiol Catalog No.:AA00J2JY CAS No.:1065101-28-1 MDL No.:MFCD11054235 MF:C11H10N2OS MW:218.2749
3,4,6-trifluoro-2-iodoaniline Catalog No.:AA01BTWE CAS No.:1065101-52-1 MDL No.:MFCD11054254 MF:C6H3F3IN MW:272.9944	Methyl 2-(pyridin-3-yl)oxazole-4-carboxylate Catalog No.:AA01DMHE CAS No.:1065102-69-3 MDL No.:MFCD18711574 MF:C10H8N2O3 MW:204.1821
methyl 5-(chlorosulfonyl)-2-iodobenzoate Catalog No.:AA01A56M CAS No.:1065102-81-9 MDL No.:MFCD12169464 MF:C8H6ClIO4S MW:360.5533	2-Chloro-6-iodo-4-(trifluoromethyl)aniline Catalog No.:AA01FOFE CAS No.:1065102-88-6 MDL No.:MFCD20492612 MF:C7H4ClF3IN MW:321.4660
Ethyl 3-(chlorosulphonyl)-1,5-diphenyl-2-methylpyrrole-4-carboxylate Catalog No.:AA00HARB CAS No.:1065103-48-1 MDL No.:MFCD03094596 MF:C20H18ClNO4S MW:403.8792	tert-Butyl 2,4-dichloro-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-7-carboxylate Catalog No.:AA008XI9 CAS No.:1065114-27-3 MDL No.:MFCD11111564 MF:C13H17Cl2N3O2 MW:318.1990
2-phenylethane-1-sulfonohydrazide Catalog No.:AA019SCV CAS No.:1065131-48-7 MDL No.:MFCD11223879 MF:C8H12N2O2S MW:200.2581	Sertindole Catalog No.:AA007CF6 CAS No.:106516-24-9 MDL No.:MFCD00867749 MF:C24H26ClFN4O MW:440.9408
3,3-dimethyl-2,3-dihydro-1h-indole-2-carboxylic acid hydrochloride Catalog No.:AA01ELFT CAS No.:106517-46-8 MDL No.:MFCD31616161 MF:C11H14ClNO2 MW:227.6874	Ethyl 5-bromo-1h-indole-7-carboxylate Catalog No.:AA0094ET CAS No.:1065181-58-9 MDL No.:MFCD21608002 MF:C11H10BrNO2 MW:268.1066
thiolane-3-carbaldehyde Catalog No.:AA01BFNF CAS No.:1065183-51-8 MDL No.:MFCD19668858 MF:C5H8OS MW:116.1814	4-Bromo-2-(ethoxymethyl)thiophene Catalog No.:AA00HARG CAS No.:1065184-23-7 MDL No.:MFCD16095116 MF:C7H9BrOS MW:221.1148
4-Bromo-2-(propoxymethyl)thiophene Catalog No.:AA00HARH CAS No.:1065184-25-9 MDL No.:MFCD16095176 MF:C8H11BrOS MW:235.1413	(5-Cyanothiophen-3-yl)boronic acid Catalog No.:AA01B9YV CAS No.:1065184-99-7 MDL No.:MFCD18383130 MF:C5H4BNO2S MW:152.9668
tert-Butyl 5-amino-3-methyl-1h-pyrazole-1-carboxylate Catalog No.:AA008Z7I CAS No.:1065204-79-6 MDL No.:MFCD11656647 MF:C9H15N3O2 MW:197.2343	(11bS)-2,6-Bis(3,5-dimethylphenyl)-4-hydroxy-8,9,10,11,12,13,14,15-octahydrodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine 4-oxide Catalog No.:AA00926F CAS No.:1065214-95-0 MDL No.:MFCD27920530 MF:C36H37O4P MW:564.6503
1-(3,5-Difluoropyridin-2-yl)ethanamine hydrochloride Catalog No.:AA0083GS CAS No.:1065267-25-5 MDL No.:MFCD17392840 MF:C7H9ClF2N2 MW:194.6096	ethyl 1,2-diamino-4-(4-chlorophenyl)-5-cyano-6-oxo-1,6-dihydropyridine-3-carboxylate Catalog No.:AA00IRRL CAS No.:106527-24-6 MDL No.:MFCD00664623 MF:C15H13ClN4O3 MW:332.7417
5-(2-Carboxyethenyl)-2-Methoxyphenyl β-D-Glucopyranosiduronic Acid Catalog No.:AA008WR5 CAS No.:1065272-10-7 MDL No.:MFCD28386035 MF:C16H18O10 MW:370.3081	Furo[2,3-c]pyridin-3(2h)-one Catalog No.:AA007UKN CAS No.:106531-52-6 MDL No.:MFCD15143777 MF:C7H5NO2 MW:135.1201
trans-Methyl methylpyrrolidine-3-carboxylate Catalog No.:AA008XNW CAS No.:1065331-03-4 MDL No.:MFCD11845468 MF:C7H13NO2 MW:143.1836	methyl 2-ethylprolinate hydrochloride Catalog No.:AA00J2HW CAS No.:1065334-12-4 MDL No.:MFCD14582610 MF:C8H15NO2 MW:157.2102
Methyl 2-(1h-1,2,4-triazol-1-yl)acetate Catalog No.:AA007CB5 CAS No.:106535-16-4 MDL No.:MFCD02186570 MF:C5H7N3O2 MW:141.1280	1-(1-Methyl-1H-1,2,4-triazol-5-yl)ethanone Catalog No.:AA008TV7 CAS No.:106535-28-8 MDL No.:MFCD09864474 MF:C5H7N3O MW:125.1286
ethyl 1-methyl-1H-1,2,4-triazole-5-carboxylate Catalog No.:AA01B4X7 CAS No.:106535-31-3 MDL No.:MFCD18338225 MF:C6H9N3O2 MW:155.1546	BOSENTAN-D4 Catalog No.:AA008XLL CAS No.:1065472-77-6 MDL No.:MFCD08063629 MF:C27H25D4N5O6S MW:555.6387
Hydroxy Bosentan-d4 Catalog No.:AA008WVN CAS No.:1065472-91-4 MDL No.:MFCD19705153 MF:C27H25D4N5O7S MW:571.6381	6-Bromo-3-iodo-2-methylpyridine Catalog No.:AA008SK7 CAS No.:1065483-59-1 MDL No.:MFCD11100952 MF:C6H5BrIN MW:297.9191
tert-Butyl 4-((4-cyanopyridin-2-yl)oxy)piperidine-1-carboxylate Catalog No.:AA00HARN CAS No.:1065484-24-3 MDL No.:MFCD18361690 MF:C16H21N3O3 MW:303.3562	1-(6-Methoxypyrimidin-4-yl)piperidin-4-ol Catalog No.:AA008ZMB CAS No.:1065484-27-6 MDL No.:MFCD09877730 MF:C10H15N3O2 MW:209.2450
1-(6-Methoxy-pyrimidin-4-yl)-piperidin-3-ol Catalog No.:AA008ZPO CAS No.:1065484-29-8 MDL No.:MFCD09877732 MF:C10H15N3O2 MW:209.2450	2-(Furan-2-ylmethoxy)-5-nitropyridine Catalog No.:AA008ZLZ CAS No.:1065484-84-5 MDL No.:MFCD10698962 MF:C10H8N2O4 MW:220.1815
Dafadine-A Catalog No.:AA008TCM CAS No.:1065506-69-5 MDL No.:MFCD13125955 MF:C23H25N3O3 MW:391.4629	2,5-dioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile Catalog No.:AA009OHI CAS No.:106551-67-1 MDL No.:MFCD00585099 MF:C10H8N2O2 MW:188.1827
2,5-Dioxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid Catalog No.:AA0083GK CAS No.:106551-76-2 MDL No.:MFCD03423969 MF:C10H9NO4 MW:207.1828	7,7-Dimethyl-2,5-dioxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid Catalog No.:AA009OBM CAS No.:106551-79-5 MDL No.:MFCD08692072 MF:C12H13NO4 MW:235.2359
SMND-309 Catalog No.:AA008TGT CAS No.:1065559-56-9 MDL No.:MFCD18072291 MF:C18H14O8 MW:358.2990	2-(4,6-Diphenyl-1,3,5-triazin-2-yl)-5-methoxyphenol Catalog No.:AA0083GG CAS No.:106556-36-9 MDL No.:MFCD23102325 MF:C22H17N3O2 MW:355.3893
2-(2-Cyanoethylamino)-2-methylpropanoic acid Catalog No.:AA0092XZ CAS No.:106556-63-2 MDL No.:MFCD12756521 MF:C7H12N2O2 MW:156.1824	2,2-Dimethyl-3-oxo-pyrrolidine-1-carboxylic acid ethyl ester Catalog No.:AA007CAW CAS No.:106556-66-5 MDL No.:MFCD09835297 MF:C9H15NO3 MW:185.2203
methyl 4-bromo-2,2-dimethyl-3-oxopyrrolidine-1-carboxylate Catalog No.:AA01FLTT CAS No.:106556-69-8 MDL No.:MFCD31539254 MF:C8H12BrNO3 MW:250.0898	methyl 1-bromocycloheptane-1-carboxylate Catalog No.:AA01ACEB CAS No.:1065573-86-5 MDL No.:MFCD26407983 MF:C9H15BrO2 MW:235.1182
1-BOC-4-(2,4-difluorobenzyl)piperazine Catalog No.:AA009479 CAS No.:1065586-31-3 MDL No.:MFCD23135937 MF:C16H22F2N2O2 MW:312.3549	1-(2,4-difluorobenzoyl)piperazine hydrochloride Catalog No.:AA01A9NY CAS No.:1065586-37-9 MDL No.:MFCD16622196 MF:C11H13ClF2N2O MW:262.6835
Faropenem sodium hemipentahydrate Catalog No.:AA00HARS CAS No.:106560-14-9 MDL No.:MFCD00868867 MF:C12H14NNaO5S MW:307.2980	4-fluoro-3-methanesulfonylbenzene-1-sulfonamide Catalog No.:AA01AB53 CAS No.:1065603-81-7 MDL No.:MFCD17977106 MF:C7H8FNO4S2 MW:253.2711
tert-Butyl 4-(hydroxymethyl)azepane-1-carboxylate Catalog No.:AA00994Z CAS No.:1065608-51-6 MDL No.:MFCD18088895 MF:C12H23NO3 MW:229.3159	1-Boc-4-formyl-azepane Catalog No.:AA00HART CAS No.:1065608-54-9 MDL No.:MFCD18088900 MF:C12H21NO3 MW:227.3000
6,7-Dihydro-5h-cyclopenta[b]pyridin-5-ol Catalog No.:AA008RZJ CAS No.:1065609-70-2 MDL No.:MFCD09800610 MF:C8H9NO MW:135.1632	(4-Oxo-thiazolidin-3-yl)-acetic acid Catalog No.:AA008S8I CAS No.:106562-27-0 MDL No.:MFCD06655129 MF:C5H7NO3S MW:161.1790
7-Amino-4-methyl-3-coumarinylacetic acid Catalog No.:AA003892 CAS No.:106562-32-7 MDL No.:MFCD00081051 MF:C12H11NO4 MW:233.2200	D-Proline, 1-acetyl-4-hydroxy-, (4S)-rel- (9CI) Catalog No.:AA009OLQ CAS No.:106564-72-1 MDL No.:MFCD20760260 MF:C7H11NO4 MW:173.1665
2-(2-methoxyethoxy)acetohydrazide Catalog No.:AA01BXUD CAS No.:1065648-56-7 MDL No.:MFCD11643818 MF:C5H12N2O3 MW:148.1604	AS 101 Catalog No.:AA007UK2 CAS No.:106566-58-9 MDL No.:MFCD01682758 MF:C2H8Cl3NO2Te+ MW:312.0494
2,4,6-Trimethyl-3-nitrobenzoic acid Catalog No.:AA007CAV CAS No.:106567-41-3 MDL No.:MFCD09260789 MF:C10H11NO4 MW:209.1986	5-Fluorobenzo[d]thiazol-2(3H)-one Catalog No.:AA007CAU CAS No.:1065678-31-0 MDL No.:MFCD09749236 MF:C7H4FNOS MW:169.1762
Parstatin (human) Catalog No.:AA008Y1V CAS No.:1065755-99-8 MDL No.:MFCD16621668 MF:C191H330N64O53S3 MW:4467.2559	Parstatin (mouse) Catalog No.:AA008Y1W CAS No.:1065756-01-5 MDL No.:MFCD16621669 MF:C189H326N58O57S3 MW:4419.1601
Hederacolchiside A1 Catalog No.:AA008Y06 CAS No.:106577-39-3 MDL No.:MFCD28124360 MF:C47H76O16 MW:897.0967	5-Methoxy-2-methyl-4-nitroaniline Catalog No.:AA003MR6 CAS No.:106579-00-4 MDL No.:MFCD00010136 MF:C8H10N2O3 MW:182.1766
7-Chloro-2,4-bis(trifluoromethyl)[1,8]naphthyridine Catalog No.:AA007C7P CAS No.:106582-41-6 MDL No.:MFCD00140156 MF:C10H3ClF6N2 MW:300.5876	2-(Thiophen-2-yl)phenol Catalog No.:AA0083G9 CAS No.:106584-13-8 MDL No.:MFCD06801791 MF:C10H8OS MW:176.2349
2-(Furan-2-yl)phenol Catalog No.:AA00HARW CAS No.:106584-14-9 MDL No.:MFCD06802855 MF:C10H8O2 MW:160.1693	Methyl 6-methylpyridazine-3-carboxylate Catalog No.:AA00355N CAS No.:106584-51-4 MDL No.:MFCD13174778 MF:C7H8N2O2 MW:152.1506
N-ALLYL-2-CHLOROPROPANAMIDE Catalog No.:AA008VG8 CAS No.:106593-37-7 MDL No.:MFCD09383935 MF:C6H10ClNO MW:147.6027	N-Allyl-3-chloropropanamide Catalog No.:AA008VGY CAS No.:106593-38-8 MDL No.:MFCD03392210 MF:C6H10ClNO MW:147.6027
3-Hydroxy-4-phenylbenzoic acid Catalog No.:AA0083G5 CAS No.:106593-48-0 MDL No.:MFCD12973936 MF:C13H10O3 MW:214.2167	4-Benzyl-1,3-dihydroquinoxalin-2-one Catalog No.:AA007C7I CAS No.:106595-91-9 MDL No.:MFCD02641650 MF:C15H14N2O MW:238.2845
Colistin Catalog No.:AA01EH1M CAS No.:1066-17-7 MDL No.:MFCD05662338 MF:C105H198N32O26 MW:2324.8944	Acetic acid, chromium(3+) salt Catalog No.:AA00ILF8 CAS No.:1066-30-4 MDL No.:MFCD00036429 MF:C2H4CrO2 MW:112.0481
Ammonium hydrogencarbonate Catalog No.:AA0038WH CAS No.:1066-33-7 MDL No.:MFCD00012138 MF:CH5NO3 MW:79.0553	Chlorodimethylsilane Catalog No.:AA003OQV CAS No.:1066-35-9 MDL No.:MFCD00000495 MF:C2H6ClSi MW:93.6075
TRIMETHYLGERMANIUM BROMIDE Catalog No.:AA003V18 CAS No.:1066-37-1 MDL No.:MFCD00000037 MF:C3H9BrGe MW:197.6476	Trimethyliodogermane Catalog No.:AA008UQV CAS No.:1066-38-2 MDL No.:MFCD00013700 MF:C3H9GeI MW:244.6480
Trimethylsilanol Catalog No.:AA0035ON CAS No.:1066-40-6 MDL No.:MFCD02751657 MF:C3H10OSi MW:90.1964	dimethylsilanediol Catalog No.:AA008W5T CAS No.:1066-42-8 MDL No.:MFCD19441445 MF:C2H8O2Si MW:92.1692
Trimethyltin bromide Catalog No.:AA003V1Y CAS No.:1066-44-0 MDL No.:MFCD00000051 MF:C3H9BrSn MW:243.7086	Trimethyltin chloride Catalog No.:AA003V1Z CAS No.:1066-45-1 MDL No.:MFCD00000520 MF:C3H9ClSn MW:199.2576
ETHYLPHOSPHONIC DICHLORIDE Catalog No.:AA003QGR CAS No.:1066-50-8 MDL No.:MFCD00002073 MF:C2H5Cl2OP MW:146.9403	(Aminomethyl)phosphonic acid Catalog No.:AA003BWN CAS No.:1066-51-9 MDL No.:MFCD00008105 MF:CH6NO3P MW:111.0370