168835-82-3,MFCD03453026
Catalog No.:AA00AO01

168835-82-3 | Su1498

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$92.00   $64.00
- +
5mg
≥98%
in stock  
$168.00   $117.00
- +
250mg
10mM in DMSO
in stock  
$3,241.00   $2,269.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00AO01
Chemical Name:
Su1498
CAS Number:
168835-82-3
Molecular Formula:
C25H30N2O2
Molecular Weight:
390.5179
MDL Number:
MFCD03453026
SMILES:
CC(c1cc(/C=C(/C(=O)NCCCc2ccccc2)\C#N)cc(c1O)C(C)C)C
Properties
Computed Properties
 
Complexity:
577  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
1  
Formal Charge:
0  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
5.8  

Downstream Synthesis Route
10537-86-7    133550-33-1   
SU1498 

[1]Patent:US5773476,1998,A

[1]CurrentPatentAssignee:ANLAIBOPHARMACEUTICALSUZHOU-CN110862335,2020,A

2038-57-5   
(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylicacid 
 
SU1498 

[1]CurrentPatentAssignee:ANLAIBOPHARMACEUTICALSUZHOU-CN110862335,2020,ALocationinpatent:Paragraph0025;0030-0032;0035-0036;0039

Literature

Title: Pro-angiogenic effects of resveratrol in brain endothelial cells: nitric oxide-mediated regulation of vascular endothelial growth factor and metalloproteinases.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120501

Title: Calcium-sensing receptor activation increases cell-cell adhesion and β-cell function.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Title: Remodeling of VE-cadherin junctions by the human herpes virus 8 G-protein coupled receptor.

Journal: Oncogene 20110113

Title: Activation of the central histaminergic system is involved in hypoxia-induced stroke tolerance in adult mice.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20110101

Title: Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects.

Journal: BMC cancer 20110101

Title: Growth factor/growth factor receptor loops in autocrine growth regulation of human prostate cancer DU145 cells.

Journal: Acta biochimica Polonica 20110101

Title: VEGF protects spinal motor neurons against chronic excitotoxic degeneration in vivo by activation of PI3-K pathway and inhibition of p38MAPK.

Journal: Journal of neurochemistry 20101201

Title: Effect of retinoic acid on renal development in newborn mice treated with an angiogenesis inhibitor.

Journal: Pediatrics international : official journal of the Japan Pediatric Society 20100601

Title: Oligomeric proanthocyanidins improve memory and enhance phosphorylation of vascular endothelial growth factor receptor-2 in senescence-accelerated mouse prone/8.

Journal: The British journal of nutrition 20100201

Title: Murine neural stem/progenitor cells protect neurons against ischemia by HIF-1alpha-regulated VEGF signaling.

Journal: PloS one 20100101

Title: FGF2 is crucial for the development of bovine luteal endothelial networks in vitro.

Journal: Reproduction (Cambridge, England) 20090901

Title: Retinal tumor imaging and volume quantification in mouse model using spectral-domain optical coherence tomography.

Journal: Optics express 20090302

Title: Effect of vascular endothelial growth factor and its receptor inhibitor on proliferation and invasion in bladder cancer.

Journal: Urologia internationalis 20090101

Title: Age impairs Flk-1 signaling and NO-mediated vasodilation in coronary arterioles.

Journal: American journal of physiology. Heart and circulatory physiology 20081201

Title: Effective delivery of an angiogenesis inhibitor by neovessel-targeted liposomes.

Journal: International journal of pharmaceutics 20080806

Title: Targeting EGFR activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in VEGFR-2 dependence in tumor endothelial cells.

Journal: Microvascular research 20080501

Title: PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20080401

Title: The effect of tyrosine kinase inhibitors, tyrphostins: AG1024 and SU1498, on autocrine growth of prostate cancer cells (DU145).

Journal: Folia histochemica et cytobiologica 20080101

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218

Title: P2y receptor-mediated angiogenesis via vascular endothelial growth factor receptor 2 signaling.

Journal: Proceedings of the Western Pharmacology Society 20070101

Title: Hypoxia-induced mitogenic factor enhances angiogenesis by promoting proliferation and migration of endothelial cells.

Journal: Experimental cell research 20061101

Title: Vascular endothelial growth factor increases the intracellular magnesium.

Journal: Biochemical and biophysical research communications 20060825

Title: Phosphoinositide 3-kinase-delta inhibitor reduces vascular permeability in a murine model of asthma.

Journal: The Journal of allergy and clinical immunology 20060801

Title: Transactivation of fetal liver kinase-1/kinase-insert domain-containing receptor by lysophosphatidylcholine induces vascular endothelial cell proliferation.

Journal: Endocrinology 20060301

Title: Accelerated arteriosclerosis of vein grafts in inducible NO synthase(-/-) mice is related to decreased endothelial progenitor cell repair.

Journal: Circulation research 20060217

Title: Vascular endothelial growth factor stimulates neurite outgrowth from cerebral cortical neurons via Rho kinase signaling.

Journal: Journal of neurobiology 20060215

Title: Retinoic acid and erythropoietin maintain alveolar development in mice treated with an angiogenesis inhibitor.

Journal: American journal of respiratory cell and molecular biology 20051201

Title: Neuroprotective effect of exogenous vascular endothelial growth factor on rat spinal cord neurons in vitro hypoxia.

Journal: Chinese medical journal 20051005

Title: Hypoxia induces the expression of membrane-type 1 matrix metalloproteinase in retinal glial cells.

Journal: Investigative ophthalmology & visual science 20051001

Title: Proliferation of endothelial and tumor epithelial cells by progestin-induced vascular endothelial growth factor from human breast cancer cells: paracrine and autocrine effects.

Journal: Endocrinology 20050801

Title: LPA-induced epithelial ovarian cancer (EOC) in vitro invasion and migration are mediated by VEGF receptor-2 (VEGF-R2).

Journal: Gynecologic oncology 20050601

Title: Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells.

Journal: Free radical biology & medicine 20050415

Title: Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells.

Journal: The Journal of biological chemistry 20050401

Title: SU1498, an inhibitor of vascular endothelial growth factor receptor 2, causes accumulation of phosphorylated ERK kinases and inhibits their activity in vivo and in vitro.

Journal: The Journal of biological chemistry 20040213

Title: Metabolism of limonoids. Limonin D-ring lactone hydrolase activity in Pseudomonas.

Journal: Journal of agricultural and food chemistry 19760101

Title: Strawn LM, et al. Flk-1 as a target for tumor growth inhibition.Cancer Res. 1996 Aug 1;56(15):3540-5.

Title: Boguslawski G, et al. SU1498, an inhibitor of vascular endothelial growth factor receptor 2, causes accumulation of phosphorylated ERK kinases and inhibits their activity in vivo and in vitro.J Biol Chem. 2004 Feb 13;279(7):5716-24.

Title: Arbiser JL, et al. Overexpression of VEGF 121 in immortalized endothelial cells causes conversion to slowly growing angiosarcoma and high level expression of the VEGF receptors VEGFR-1 and VEGFR-2 in vivo.Am J Pathol. 2000 Apr;156(4):1469-76.

Title: Mesti T, et al. Metabolic impact of anti-angiogenic agents on U87 glioma cells.PLoS One. 2014 Jun 12;9(6):e99198.

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Related Products of 168835-82-3
Tags:168835-82-3 Molecular Formula|168835-82-3 MDL|168835-82-3 SMILES|168835-82-3 Su1498
Catalog No.: AA00AO01
168835-82-3,MFCD03453026
168835-82-3 | Su1498
Pack Size: 1mg
Purity: ≥98%
in stock
$92.00 $64.00
Pack Size: 5mg
Purity: ≥98%
in stock
$168.00 $117.00
Pack Size: 250mg
Purity: 10mM in DMSO
in stock
$3,241.00 $2,269.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00AO01
Chemical Name: Su1498
CAS Number: 168835-82-3
Molecular Formula: C25H30N2O2
Molecular Weight: 390.5179
MDL Number: MFCD03453026
SMILES: CC(c1cc(/C=C(/C(=O)NCCCc2ccccc2)\C#N)cc(c1O)C(C)C)C
Properties
Complexity: 577  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 1  
Formal Charge: 0  
Heavy Atom Count: 29  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 8  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 5.8  
Downstream Synthesis Route
10537-86-7    133550-33-1   
SU1498 

[1]Patent:US5773476,1998,A

2078-54-8    168835-82-3 

[1]CurrentPatentAssignee:ANLAIBOPHARMACEUTICALSUZHOU-CN110862335,2020,A

2038-57-5   
(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylicacid 
 
SU1498 

[1]CurrentPatentAssignee:ANLAIBOPHARMACEUTICALSUZHOU-CN110862335,2020,ALocationinpatent:Paragraph0025;0030-0032;0035-0036;0039

Literature fold

Title: Pro-angiogenic effects of resveratrol in brain endothelial cells: nitric oxide-mediated regulation of vascular endothelial growth factor and metalloproteinases.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism20120501

Title: Calcium-sensing receptor activation increases cell-cell adhesion and β-cell function.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology20120101

Title: Remodeling of VE-cadherin junctions by the human herpes virus 8 G-protein coupled receptor.

Journal: Oncogene20110113

Title: Activation of the central histaminergic system is involved in hypoxia-induced stroke tolerance in adult mice.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism20110101

Title: Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects.

Journal: BMC cancer20110101

Title: Growth factor/growth factor receptor loops in autocrine growth regulation of human prostate cancer DU145 cells.

Journal: Acta biochimica Polonica20110101

Title: VEGF protects spinal motor neurons against chronic excitotoxic degeneration in vivo by activation of PI3-K pathway and inhibition of p38MAPK.

Journal: Journal of neurochemistry20101201

Title: Effect of retinoic acid on renal development in newborn mice treated with an angiogenesis inhibitor.

Journal: Pediatrics international : official journal of the Japan Pediatric Society20100601

Title: Oligomeric proanthocyanidins improve memory and enhance phosphorylation of vascular endothelial growth factor receptor-2 in senescence-accelerated mouse prone/8.

Journal: The British journal of nutrition20100201

Title: Murine neural stem/progenitor cells protect neurons against ischemia by HIF-1alpha-regulated VEGF signaling.

Journal: PloS one20100101

Title: FGF2 is crucial for the development of bovine luteal endothelial networks in vitro.

Journal: Reproduction (Cambridge, England)20090901

Title: Retinal tumor imaging and volume quantification in mouse model using spectral-domain optical coherence tomography.

Journal: Optics express20090302

Title: Effect of vascular endothelial growth factor and its receptor inhibitor on proliferation and invasion in bladder cancer.

Journal: Urologia internationalis20090101

Title: Age impairs Flk-1 signaling and NO-mediated vasodilation in coronary arterioles.

Journal: American journal of physiology. Heart and circulatory physiology20081201

Title: Effective delivery of an angiogenesis inhibitor by neovessel-targeted liposomes.

Journal: International journal of pharmaceutics20080806

Title: Targeting EGFR activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in VEGFR-2 dependence in tumor endothelial cells.

Journal: Microvascular research20080501

Title: PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2.

Journal: Arteriosclerosis, thrombosis, and vascular biology20080401

Title: The effect of tyrosine kinase inhibitors, tyrphostins: AG1024 and SU1498, on autocrine growth of prostate cancer cells (DU145).

Journal: Folia histochemica et cytobiologica20080101

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America20071218

Title: P2y receptor-mediated angiogenesis via vascular endothelial growth factor receptor 2 signaling.

Journal: Proceedings of the Western Pharmacology Society20070101

Title: Hypoxia-induced mitogenic factor enhances angiogenesis by promoting proliferation and migration of endothelial cells.

Journal: Experimental cell research20061101

Title: Vascular endothelial growth factor increases the intracellular magnesium.

Journal: Biochemical and biophysical research communications20060825

Title: Phosphoinositide 3-kinase-delta inhibitor reduces vascular permeability in a murine model of asthma.

Journal: The Journal of allergy and clinical immunology20060801

Title: Transactivation of fetal liver kinase-1/kinase-insert domain-containing receptor by lysophosphatidylcholine induces vascular endothelial cell proliferation.

Journal: Endocrinology20060301

Title: Accelerated arteriosclerosis of vein grafts in inducible NO synthase(-/-) mice is related to decreased endothelial progenitor cell repair.

Journal: Circulation research20060217

Title: Vascular endothelial growth factor stimulates neurite outgrowth from cerebral cortical neurons via Rho kinase signaling.

Journal: Journal of neurobiology20060215

Title: Retinoic acid and erythropoietin maintain alveolar development in mice treated with an angiogenesis inhibitor.

Journal: American journal of respiratory cell and molecular biology20051201

Title: Neuroprotective effect of exogenous vascular endothelial growth factor on rat spinal cord neurons in vitro hypoxia.

Journal: Chinese medical journal20051005

Title: Hypoxia induces the expression of membrane-type 1 matrix metalloproteinase in retinal glial cells.

Journal: Investigative ophthalmology & visual science20051001

Title: Proliferation of endothelial and tumor epithelial cells by progestin-induced vascular endothelial growth factor from human breast cancer cells: paracrine and autocrine effects.

Journal: Endocrinology20050801

Title: LPA-induced epithelial ovarian cancer (EOC) in vitro invasion and migration are mediated by VEGF receptor-2 (VEGF-R2).

Journal: Gynecologic oncology20050601

Title: Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells.

Journal: Free radical biology & medicine20050415

Title: Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells.

Journal: The Journal of biological chemistry20050401

Title: SU1498, an inhibitor of vascular endothelial growth factor receptor 2, causes accumulation of phosphorylated ERK kinases and inhibits their activity in vivo and in vitro.

Journal: The Journal of biological chemistry20040213

Title: Metabolism of limonoids. Limonin D-ring lactone hydrolase activity in Pseudomonas.

Journal: Journal of agricultural and food chemistry19760101

Title: Strawn LM, et al. Flk-1 as a target for tumor growth inhibition.Cancer Res. 1996 Aug 1;56(15):3540-5.

Title: Boguslawski G, et al. SU1498, an inhibitor of vascular endothelial growth factor receptor 2, causes accumulation of phosphorylated ERK kinases and inhibits their activity in vivo and in vitro.J Biol Chem. 2004 Feb 13;279(7):5716-24.

Title: Arbiser JL, et al. Overexpression of VEGF 121 in immortalized endothelial cells causes conversion to slowly growing angiosarcoma and high level expression of the VEGF receptors VEGFR-1 and VEGFR-2 in vivo.Am J Pathol. 2000 Apr;156(4):1469-76.

Title: Mesti T, et al. Metabolic impact of anti-angiogenic agents on U87 glioma cells.PLoS One. 2014 Jun 12;9(6):e99198.

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